date generated: “2019-06-11”

Background

Mitch performs multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##         rna_LGvHG rna_HGvHGV
## A1BG     0.971638  -0.731457
## A1CF     2.247960  -0.344901
## A2M      0.154344  -2.167180
## A2M-AS1  1.534120  -0.310504
## A4GALT   1.207370  59.565200
## AAAS     0.565670  -6.516140

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 16368
duplicated_genes_present 0
num_profile_genes_in_sets 7556
num_profile_genes_not_in_sets 8812
profile_pearson_correl 0.00044
profile_spearman_correl -0.00536

Here is a scatterplot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all genes.

Here is the distribution of genes in the quadrants/sectors

Input genesets

Here are some metrics about the gene sets used: [1] “GMT file of genesets: ReactomePathways.gmt”

Gene sets metrics
Gene sets metrics
num_genesets 2231
num_genesets_excluded 966
num_genesets_included 1265
num_sets_significant 542

null device 1

Enrichment scatterplot with taucharts

All sets with p.adjustMANOVA<0.05. Try hovering over the points.

Enrichment scatterplot with taucharts

Top N sets irrespective of FDR. Try hovering over the points.

## Prioritisation done by effect

## A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top gene sets
set setSize pMANOVA p.adjustMANOVA s.dist confESp s.rna_LGvHG s.rna_HGvHGV p.rna_LGvHG p.rna_HGvHGV
Cholesterol biosynthesis 23 1.70e-10 3.84e-09 0.808 NA 0.805 -0.0701 2.30e-11 5.61e-01
Unwinding of DNA 12 2.54e-05 2.14e-04 0.766 NA 0.727 0.2410 1.31e-05 1.48e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 13 3.85e-05 2.99e-04 0.721 NA -0.226 -0.6840 1.57e-01 1.93e-05
Initial triggering of complement 13 7.58e-05 5.33e-04 0.700 NA 0.517 -0.4710 1.24e-03 3.30e-03
Regulation of Complement cascade 30 1.14e-09 2.37e-08 0.678 NA 0.553 -0.3920 1.54e-07 2.01e-04
Voltage gated Potassium channels 14 1.01e-04 6.83e-04 0.663 NA -0.109 0.6540 4.78e-01 2.29e-05
Adenylate cyclase inhibitory pathway 11 7.98e-04 3.72e-03 0.658 NA -0.020 0.6570 9.08e-01 1.59e-04
Calnexin/calreticulin cycle 26 9.81e-08 1.44e-06 0.643 NA -0.640 -0.0676 1.64e-08 5.51e-01
Insulin receptor recycling 23 1.32e-06 1.71e-05 0.628 NA -0.515 0.3600 1.90e-05 2.83e-03
ER Quality Control Compartment (ERQC) 21 4.99e-06 5.49e-05 0.623 NA -0.623 0.0158 7.81e-07 9.00e-01
DNA strand elongation 32 9.14e-09 1.56e-07 0.620 NA 0.566 0.2540 3.05e-08 1.29e-02
Removal of the Flap Intermediate 14 3.01e-04 1.72e-03 0.620 NA 0.512 0.3490 9.09e-04 2.36e-02
Folding of actin by CCT/TriC 10 3.16e-03 1.14e-02 0.618 NA -0.564 -0.2540 2.01e-03 1.65e-01
Regulation of TLR by endogenous ligand 13 6.35e-04 3.09e-03 0.615 NA 0.608 -0.0953 1.48e-04 5.52e-01
Processive synthesis on the lagging strand 15 2.38e-04 1.39e-03 0.608 NA 0.531 0.2970 3.74e-04 4.67e-02
Leading Strand Synthesis 14 5.09e-04 2.60e-03 0.600 NA 0.512 0.3130 9.14e-04 4.29e-02
Polymerase switching 14 5.09e-04 2.60e-03 0.600 NA 0.512 0.3130 9.14e-04 4.29e-02
Polymerase switching on the C-strand of the telomere 14 5.09e-04 2.60e-03 0.600 NA 0.512 0.3130 9.14e-04 4.29e-02
Complement cascade 36 4.92e-09 8.76e-08 0.597 NA 0.462 -0.3790 1.65e-06 8.37e-05
MET activates RAS signaling 10 5.47e-03 1.72e-02 0.591 NA -0.532 0.2570 3.61e-03 1.59e-01
Effects of PIP2 hydrolysis 21 1.84e-05 1.60e-04 0.590 NA -0.251 0.5340 4.65e-02 2.29e-05
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 2.07e-08 3.36e-07 0.580 NA -0.575 -0.0809 3.96e-09 4.08e-01
ROS and RNS production in phagocytes 26 3.19e-06 3.74e-05 0.571 NA -0.395 0.4130 4.89e-04 2.68e-04
SRP-dependent cotranslational protein targeting to membrane 108 5.71e-23 7.22e-21 0.562 NA -0.478 -0.2950 8.76e-18 1.19e-07
Ribosomal scanning and start codon recognition 57 4.01e-12 1.15e-10 0.553 NA -0.412 -0.3690 7.45e-08 1.45e-06


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist confESp s.rna_LGvHG s.rna_HGvHGV p.rna_LGvHG p.rna_HGvHGV
Cholesterol biosynthesis 23 1.70e-10 3.84e-09 0.8080 NA 0.805000 -0.070100 2.30e-11 5.61e-01
Unwinding of DNA 12 2.54e-05 2.14e-04 0.7660 NA 0.727000 0.241000 1.31e-05 1.48e-01
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 13 3.85e-05 2.99e-04 0.7210 NA -0.226000 -0.684000 1.57e-01 1.93e-05
Initial triggering of complement 13 7.58e-05 5.33e-04 0.7000 NA 0.517000 -0.471000 1.24e-03 3.30e-03
Regulation of Complement cascade 30 1.14e-09 2.37e-08 0.6780 NA 0.553000 -0.392000 1.54e-07 2.01e-04
Voltage gated Potassium channels 14 1.01e-04 6.83e-04 0.6630 NA -0.109000 0.654000 4.78e-01 2.29e-05
Adenylate cyclase inhibitory pathway 11 7.98e-04 3.72e-03 0.6580 NA -0.020000 0.657000 9.08e-01 1.59e-04
Calnexin/calreticulin cycle 26 9.81e-08 1.44e-06 0.6430 NA -0.640000 -0.067600 1.64e-08 5.51e-01
Insulin receptor recycling 23 1.32e-06 1.71e-05 0.6280 NA -0.515000 0.360000 1.90e-05 2.83e-03
ER Quality Control Compartment (ERQC) 21 4.99e-06 5.49e-05 0.6230 NA -0.623000 0.015800 7.81e-07 9.00e-01
DNA strand elongation 32 9.14e-09 1.56e-07 0.6200 NA 0.566000 0.254000 3.05e-08 1.29e-02
Removal of the Flap Intermediate 14 3.01e-04 1.72e-03 0.6200 NA 0.512000 0.349000 9.09e-04 2.36e-02
Folding of actin by CCT/TriC 10 3.16e-03 1.14e-02 0.6180 NA -0.564000 -0.254000 2.01e-03 1.65e-01
Regulation of TLR by endogenous ligand 13 6.35e-04 3.09e-03 0.6150 NA 0.608000 -0.095300 1.48e-04 5.52e-01
Processive synthesis on the lagging strand 15 2.38e-04 1.39e-03 0.6080 NA 0.531000 0.297000 3.74e-04 4.67e-02
Leading Strand Synthesis 14 5.09e-04 2.60e-03 0.6000 NA 0.512000 0.313000 9.14e-04 4.29e-02
Polymerase switching 14 5.09e-04 2.60e-03 0.6000 NA 0.512000 0.313000 9.14e-04 4.29e-02
Polymerase switching on the C-strand of the telomere 14 5.09e-04 2.60e-03 0.6000 NA 0.512000 0.313000 9.14e-04 4.29e-02
Complement cascade 36 4.92e-09 8.76e-08 0.5970 NA 0.462000 -0.379000 1.65e-06 8.37e-05
MET activates RAS signaling 10 5.47e-03 1.72e-02 0.5910 NA -0.532000 0.257000 3.61e-03 1.59e-01
Effects of PIP2 hydrolysis 21 1.84e-05 1.60e-04 0.5900 NA -0.251000 0.534000 4.65e-02 2.29e-05
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 2.07e-08 3.36e-07 0.5800 NA -0.575000 -0.080900 3.96e-09 4.08e-01
ROS and RNS production in phagocytes 26 3.19e-06 3.74e-05 0.5710 NA -0.395000 0.413000 4.89e-04 2.68e-04
SRP-dependent cotranslational protein targeting to membrane 108 5.71e-23 7.22e-21 0.5620 NA -0.478000 -0.295000 8.76e-18 1.19e-07
Ribosomal scanning and start codon recognition 57 4.01e-12 1.15e-10 0.5530 NA -0.412000 -0.369000 7.45e-08 1.45e-06
Regulation of signaling by CBL 13 2.83e-03 1.05e-02 0.5500 NA -0.496000 0.238000 1.96e-03 1.38e-01
Translation initiation complex formation 57 1.18e-11 3.32e-10 0.5420 NA -0.406000 -0.359000 1.17e-07 2.81e-06
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 25 1.81e-05 1.59e-04 0.5390 NA 0.528000 0.108000 4.80e-06 3.50e-01
Diseases associated with N-glycosylation of proteins 17 5.93e-04 2.96e-03 0.5390 NA -0.267000 -0.468000 5.67e-02 8.37e-04
Lagging Strand Synthesis 20 1.74e-04 1.07e-03 0.5360 NA 0.468000 0.261000 2.89e-04 4.30e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 58 1.29e-11 3.55e-10 0.5360 NA -0.389000 -0.369000 3.10e-07 1.15e-06
Uptake and function of anthrax toxins 11 8.91e-03 2.56e-02 0.5350 NA -0.532000 0.055800 2.23e-03 7.49e-01
Formation of the ternary complex, and subsequently, the 43S complex 50 4.34e-10 9.30e-09 0.5350 NA -0.424000 -0.327000 2.15e-07 6.41e-05
ATF6 (ATF6-alpha) activates chaperone genes 10 1.34e-02 3.47e-02 0.5350 NA -0.478000 -0.240000 8.80e-03 1.89e-01
L13a-mediated translational silencing of Ceruloplasmin expression 108 8.64e-21 7.80e-19 0.5340 NA -0.401000 -0.352000 6.24e-13 2.53e-10
RUNX3 regulates p14-ARF 10 1.44e-02 3.63e-02 0.5330 NA -0.494000 0.199000 6.81e-03 2.75e-01
Viral mRNA Translation 86 1.19e-16 5.80e-15 0.5330 NA -0.420000 -0.327000 1.58e-11 1.62e-07
Peptide chain elongation 86 1.25e-16 5.88e-15 0.5320 NA -0.418000 -0.329000 2.05e-11 1.31e-07
GTP hydrolysis and joining of the 60S ribosomal subunit 109 7.40e-21 7.20e-19 0.5320 NA -0.397000 -0.354000 7.93e-13 1.70e-10
Cytosolic tRNA aminoacylation 24 3.77e-05 2.96e-04 0.5310 NA -0.283000 -0.449000 1.66e-02 1.38e-04
Eukaryotic Translation Elongation 90 3.35e-17 1.76e-15 0.5300 NA -0.422000 -0.320000 4.38e-12 1.61e-07
Ephrin signaling 18 5.63e-04 2.84e-03 0.5280 NA -0.208000 0.485000 1.27e-01 3.67e-04
Resolution of D-loop Structures through Holliday Junction Intermediates 30 3.67e-06 4.26e-05 0.5270 NA 0.525000 0.045700 6.30e-07 6.65e-01
IRE1alpha activates chaperones 49 1.42e-09 2.91e-08 0.5270 NA -0.526000 0.034100 1.87e-10 6.79e-01
Formation of a pool of free 40S subunits 98 1.96e-18 1.18e-16 0.5260 NA -0.403000 -0.338000 5.34e-12 7.25e-09
Interaction between L1 and Ankyrins 21 1.72e-04 1.07e-03 0.5250 NA 0.001030 0.525000 9.93e-01 3.13e-05
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 91 7.55e-17 3.82e-15 0.5210 NA -0.416000 -0.314000 7.06e-12 2.29e-07
Collagen chain trimerization 18 6.47e-04 3.10e-03 0.5210 NA 0.500000 0.146000 2.40e-04 2.82e-01
Cap-dependent Translation Initiation 116 4.08e-21 4.30e-19 0.5190 NA -0.379000 -0.354000 1.70e-12 4.32e-11
Eukaryotic Translation Initiation 116 4.08e-21 4.30e-19 0.5190 NA -0.379000 -0.354000 1.70e-12 4.32e-11
AKT phosphorylates targets in the cytosol 14 3.48e-03 1.24e-02 0.5190 NA -0.509000 -0.102000 9.83e-04 5.07e-01
HDMs demethylate histones 22 1.64e-04 1.02e-03 0.5130 NA -0.406000 -0.314000 9.92e-04 1.08e-02
Generation of second messenger molecules 15 2.93e-03 1.09e-02 0.5110 NA -0.272000 0.432000 6.87e-02 3.74e-03
Selenocysteine synthesis 90 5.33e-16 2.25e-14 0.5100 NA -0.391000 -0.328000 1.47e-10 7.93e-08
Biotin transport and metabolism 11 1.36e-02 3.50e-02 0.5090 NA -0.243000 -0.447000 1.62e-01 1.02e-02
ATF6 (ATF6-alpha) activates chaperones 12 9.34e-03 2.60e-02 0.5090 NA -0.433000 -0.266000 9.38e-03 1.10e-01
XBP1(S) activates chaperone genes 47 1.37e-08 2.31e-07 0.5070 NA -0.506000 0.032600 1.89e-09 6.99e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 14 4.62e-03 1.53e-02 0.5050 NA 0.283000 0.418000 6.67e-02 6.75e-03
Defective EXT2 causes exostoses 2 14 4.62e-03 1.53e-02 0.5050 NA 0.283000 0.418000 6.67e-02 6.75e-03
NCAM1 interactions 21 3.19e-04 1.80e-03 0.5050 NA 0.202000 0.463000 1.10e-01 2.41e-04
Advanced glycosylation endproduct receptor signaling 10 2.16e-02 5.03e-02 0.5050 NA -0.448000 -0.231000 1.41e-02 2.05e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 111 3.94e-19 2.77e-17 0.5040 NA -0.375000 -0.337000 8.36e-12 9.05e-10
Nonsense-Mediated Decay (NMD) 111 3.94e-19 2.77e-17 0.5040 NA -0.375000 -0.337000 8.36e-12 9.05e-10
Eukaryotic Translation Termination 89 2.02e-15 7.29e-14 0.5030 NA -0.398000 -0.307000 8.27e-11 5.54e-07
Cell-extracellular matrix interactions 13 7.47e-03 2.22e-02 0.5020 NA -0.442000 0.239000 5.79e-03 1.36e-01
Removal of the Flap Intermediate from the C-strand 10 2.35e-02 5.32e-02 0.4990 NA 0.384000 0.318000 3.54e-02 8.15e-02
Common Pathway of Fibrin Clot Formation 16 2.83e-03 1.05e-02 0.4960 NA 0.345000 -0.356000 1.68e-02 1.37e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 4.17e-03 1.40e-02 0.4950 NA -0.297000 0.396000 4.62e-02 7.96e-03
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 4.17e-03 1.40e-02 0.4950 NA -0.297000 0.396000 4.62e-02 7.96e-03
Resolution of D-Loop Structures 31 1.13e-05 1.10e-04 0.4950 NA 0.492000 0.051500 2.09e-06 6.20e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 2.79e-03 1.05e-02 0.4940 NA -0.457000 -0.187000 1.54e-03 1.95e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 3.19e-04 1.80e-03 0.4940 NA -0.494000 0.027100 6.14e-05 8.26e-01
SHC-mediated cascade:FGFR1 10 2.74e-02 5.97e-02 0.4910 NA -0.371000 0.322000 4.20e-02 7.83e-02
Processive synthesis on the C-strand of the telomere 11 1.90e-02 4.50e-02 0.4890 NA 0.421000 0.249000 1.56e-02 1.53e-01
Striated Muscle Contraction 22 3.64e-04 2.00e-03 0.4890 NA 0.296000 0.389000 1.62e-02 1.59e-03
NF-kB is activated and signals survival 12 1.34e-02 3.47e-02 0.4880 NA -0.431000 -0.230000 9.80e-03 1.67e-01
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 2.00e-02 4.70e-02 0.4880 NA -0.406000 0.271000 1.97e-02 1.20e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 6.69e-03 2.03e-02 0.4870 NA 0.441000 0.208000 4.28e-03 1.78e-01
Methylation 11 2.09e-02 4.87e-02 0.4860 NA 0.269000 -0.404000 1.22e-01 2.03e-02
PKA activation 14 7.14e-03 2.13e-02 0.4850 NA 0.016500 0.485000 9.15e-01 1.68e-03
Defective B3GAT3 causes JDSSDHD 19 1.23e-03 5.25e-03 0.4840 NA 0.201000 0.440000 1.29e-01 8.91e-04
mRNA 3’-end processing 56 3.43e-09 6.47e-08 0.4820 NA -0.138000 -0.461000 7.41e-02 2.33e-09
Phase 2 - plateau phase 11 2.26e-02 5.22e-02 0.4790 NA 0.044300 0.477000 7.99e-01 6.16e-03
Homologous DNA Pairing and Strand Exchange 40 1.04e-06 1.37e-05 0.4790 NA 0.463000 0.122000 4.02e-07 1.81e-01
Transferrin endocytosis and recycling 29 5.28e-05 3.88e-04 0.4770 NA -0.421000 0.225000 8.70e-05 3.63e-02
Potassium Channels 35 6.74e-06 7.23e-05 0.4770 NA -0.073900 0.471000 4.49e-01 1.40e-06
WNT ligand biogenesis and trafficking 15 6.22e-03 1.90e-02 0.4760 NA -0.175000 0.443000 2.41e-01 2.97e-03
rRNA modification in the nucleus and cytosol 58 3.82e-09 7.01e-08 0.4720 NA -0.234000 -0.410000 2.09e-03 6.87e-08
SHC-mediated cascade:FGFR2 10 3.65e-02 7.52e-02 0.4710 NA -0.190000 0.431000 2.98e-01 1.83e-02
Nucleobase biosynthesis 15 7.74e-03 2.29e-02 0.4660 NA 0.249000 -0.394000 9.54e-02 8.20e-03
DAP12 signaling 19 2.17e-03 8.58e-03 0.4650 NA -0.356000 0.300000 7.25e-03 2.37e-02
Selenoamino acid metabolism 112 1.89e-16 8.52e-15 0.4640 NA -0.324000 -0.332000 3.15e-09 1.27e-09
Defective B4GALT7 causes EDS, progeroid type 19 2.11e-03 8.39e-03 0.4640 NA 0.247000 0.393000 6.20e-02 3.05e-03
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 3.99e-02 8.07e-02 0.4630 NA -0.062000 -0.459000 7.34e-01 1.19e-02
Formation of Fibrin Clot (Clotting Cascade) 29 9.91e-05 6.74e-04 0.4620 NA 0.381000 -0.261000 3.87e-04 1.49e-02
Activation of GABAB receptors 22 9.13e-04 4.10e-03 0.4610 NA -0.007260 0.461000 9.53e-01 1.83e-04
GABA B receptor activation 22 9.13e-04 4.10e-03 0.4610 NA -0.007260 0.461000 9.53e-01 1.83e-04
CASP8 activity is inhibited 10 4.16e-02 8.31e-02 0.4600 NA -0.043600 -0.458000 8.11e-01 1.21e-02
Dimerization of procaspase-8 10 4.16e-02 8.31e-02 0.4600 NA -0.043600 -0.458000 8.11e-01 1.21e-02
Regulation by c-FLIP 10 4.16e-02 8.31e-02 0.4600 NA -0.043600 -0.458000 8.11e-01 1.21e-02
Presynaptic phase of homologous DNA pairing and strand exchange 37 8.10e-06 8.40e-05 0.4590 NA 0.436000 0.143000 4.36e-06 1.32e-01
Defects in cobalamin (B12) metabolism 12 2.35e-02 5.32e-02 0.4580 NA 0.269000 -0.370000 1.06e-01 2.63e-02
rRNA processing in the nucleus and cytosol 186 4.71e-26 1.19e-23 0.4580 NA -0.285000 -0.358000 2.10e-11 3.65e-17
Other semaphorin interactions 12 2.41e-02 5.41e-02 0.4560 NA -0.116000 0.441000 4.87e-01 8.22e-03
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.32e-02 3.44e-02 0.4530 NA 0.437000 0.122000 4.67e-03 4.29e-01
Metabolism of folate and pterines 15 9.78e-03 2.71e-02 0.4530 NA -0.130000 -0.434000 3.82e-01 3.62e-03
The activation of arylsulfatases 10 4.61e-02 9.02e-02 0.4530 NA -0.059000 -0.449000 7.47e-01 1.40e-02
Regulation of PTEN mRNA translation 12 2.50e-02 5.52e-02 0.4520 NA -0.131000 -0.433000 4.32e-01 9.43e-03
Intraflagellar transport 37 1.14e-05 1.10e-04 0.4520 NA 0.281000 0.354000 3.11e-03 1.93e-04
Defects in vitamin and cofactor metabolism 20 2.20e-03 8.65e-03 0.4520 NA 0.011000 -0.452000 9.32e-01 4.68e-04
Mitochondrial tRNA aminoacylation 21 1.66e-03 6.75e-03 0.4520 NA 0.184000 -0.413000 1.45e-01 1.06e-03
mRNA Splicing - Major Pathway 174 8.93e-24 1.41e-21 0.4520 NA -0.203000 -0.404000 4.10e-06 4.12e-20
Major pathway of rRNA processing in the nucleolus and cytosol 176 5.91e-24 1.07e-21 0.4510 NA -0.288000 -0.347000 4.58e-11 2.19e-15
SHC-mediated cascade:FGFR4 10 5.07e-02 9.76e-02 0.4470 NA -0.391000 0.216000 3.21e-02 2.37e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 21 1.86e-03 7.46e-03 0.4460 NA -0.101000 -0.435000 4.23e-01 5.62e-04
GABA receptor activation 26 4.35e-04 2.28e-03 0.4460 NA 0.052000 0.442000 6.47e-01 9.41e-05
Long-term potentiation 18 4.92e-03 1.61e-02 0.4430 NA 0.224000 0.382000 1.00e-01 5.00e-03
CLEC7A (Dectin-1) induces NFAT activation 11 4.01e-02 8.09e-02 0.4430 NA -0.198000 0.396000 2.55e-01 2.30e-02
Tie2 Signaling 13 2.23e-02 5.15e-02 0.4420 NA -0.426000 0.120000 7.87e-03 4.54e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 20 2.97e-03 1.09e-02 0.4420 NA 0.323000 -0.302000 1.25e-02 1.94e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 20 2.97e-03 1.09e-02 0.4420 NA 0.323000 -0.302000 1.25e-02 1.94e-02
G-protein mediated events 40 9.18e-06 9.29e-05 0.4410 NA -0.106000 0.428000 2.47e-01 2.85e-06
Translation 286 1.52e-36 8.99e-34 0.4400 NA -0.273000 -0.345000 2.13e-15 1.04e-23
PLC beta mediated events 39 1.28e-05 1.22e-04 0.4400 NA -0.123000 0.422000 1.84e-01 5.02e-06
Scavenging by Class A Receptors 11 4.08e-02 8.21e-02 0.4400 NA -0.415000 -0.144000 1.71e-02 4.08e-01
mRNA Splicing 183 1.47e-23 2.06e-21 0.4380 NA -0.198000 -0.391000 3.89e-06 7.16e-20
Cargo concentration in the ER 29 2.56e-04 1.49e-03 0.4370 NA -0.426000 0.094600 7.04e-05 3.78e-01
Activation of ATR in response to replication stress 36 3.29e-05 2.69e-04 0.4370 NA 0.396000 0.184000 3.91e-05 5.65e-02
G alpha (z) signalling events 32 1.16e-04 7.64e-04 0.4350 NA -0.100000 0.424000 3.26e-01 3.36e-05
RIP-mediated NFkB activation via ZBP1 15 1.40e-02 3.58e-02 0.4350 NA -0.414000 -0.132000 5.47e-03 3.75e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 71 1.81e-09 3.47e-08 0.4350 NA -0.119000 -0.418000 8.26e-02 1.11e-09
Constitutive Signaling by EGFRvIII 14 1.92e-02 4.54e-02 0.4350 NA -0.412000 0.139000 7.65e-03 3.66e-01
Signaling by EGFRvIII in Cancer 14 1.92e-02 4.54e-02 0.4350 NA -0.412000 0.139000 7.65e-03 3.66e-01
FCERI mediated Ca+2 mobilization 21 2.74e-03 1.04e-02 0.4340 NA -0.293000 0.320000 2.01e-02 1.11e-02
Mismatch Repair 15 1.43e-02 3.62e-02 0.4340 NA 0.407000 0.150000 6.34e-03 3.14e-01
Antimicrobial peptides 16 1.14e-02 3.06e-02 0.4310 NA 0.337000 0.268000 1.95e-02 6.35e-02
HATs acetylate histones 88 2.44e-11 6.42e-10 0.4300 NA -0.190000 -0.386000 2.05e-03 3.93e-10
SHC1 events in EGFR signaling 10 6.34e-02 1.14e-01 0.4300 NA -0.388000 0.185000 3.36e-02 3.11e-01
TGF-beta receptor signaling activates SMADs 32 1.41e-04 8.99e-04 0.4300 NA -0.417000 -0.101000 4.38e-05 3.21e-01
Caspase activation via Death Receptors in the presence of ligand 13 2.77e-02 6.02e-02 0.4290 NA -0.003120 -0.429000 9.84e-01 7.41e-03
MAPK targets/ Nuclear events mediated by MAP kinases 29 3.64e-04 2.00e-03 0.4280 NA -0.362000 0.228000 7.31e-04 3.39e-02
Influenza Life Cycle 140 2.09e-17 1.15e-15 0.4280 NA -0.327000 -0.276000 2.37e-11 1.81e-08
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 12 3.66e-02 7.52e-02 0.4280 NA -0.224000 -0.365000 1.79e-01 2.88e-02
Unfolded Protein Response (UPR) 87 4.60e-11 1.14e-09 0.4280 NA -0.426000 -0.043000 6.85e-12 4.88e-01
Phosphorylation of the APC/C 19 5.65e-03 1.76e-02 0.4280 NA 0.276000 -0.327000 3.75e-02 1.37e-02
ERKs are inactivated 13 2.95e-02 6.36e-02 0.4260 NA -0.406000 0.129000 1.13e-02 4.19e-01
Vitamin B5 (pantothenate) metabolism 16 1.32e-02 3.44e-02 0.4260 NA 0.212000 -0.369000 1.42e-01 1.06e-02
Phase 0 - rapid depolarisation 25 1.19e-03 5.15e-03 0.4240 NA 0.096800 0.412000 4.02e-01 3.59e-04
Transport of Mature Transcript to Cytoplasm 80 4.59e-10 9.67e-09 0.4240 NA -0.116000 -0.407000 7.21e-02 3.05e-10
Defective B3GALT6 causes EDSP2 and SEMDJL1 19 5.94e-03 1.83e-02 0.4230 NA 0.188000 0.380000 1.57e-01 4.19e-03
RAF-independent MAPK1/3 activation 21 3.67e-03 1.29e-02 0.4230 NA -0.312000 0.286000 1.33e-02 2.32e-02
Mitotic Telophase/Cytokinesis 13 3.08e-02 6.60e-02 0.4230 NA -0.000964 -0.423000 9.95e-01 8.35e-03
Uptake and actions of bacterial toxins 24 1.68e-03 6.82e-03 0.4220 NA -0.359000 0.223000 2.34e-03 5.87e-02
tRNA Aminoacylation 42 1.35e-05 1.26e-04 0.4220 NA -0.045400 -0.420000 6.11e-01 2.53e-06
Negative regulation of MET activity 18 8.49e-03 2.47e-02 0.4210 NA -0.370000 0.202000 6.63e-03 1.37e-01
RNA Polymerase II Transcription Termination 65 3.10e-08 4.90e-07 0.4210 NA -0.129000 -0.401000 7.30e-02 2.27e-08
Defective B3GALTL causes Peters-plus syndrome (PpS) 21 3.69e-03 1.29e-02 0.4210 NA 0.177000 0.382000 1.61e-01 2.43e-03
RORA activates gene expression 18 8.19e-03 2.40e-02 0.4210 NA -0.252000 -0.337000 6.42e-02 1.33e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 8.72e-03 2.51e-02 0.4200 NA -0.410000 0.089200 2.59e-03 5.13e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 8.72e-03 2.51e-02 0.4200 NA -0.410000 0.089200 2.59e-03 5.13e-01
Lysosome Vesicle Biogenesis 32 2.21e-04 1.30e-03 0.4200 NA -0.408000 0.097600 6.46e-05 3.40e-01
N-Glycan antennae elongation 11 5.41e-02 1.03e-01 0.4190 NA -0.303000 -0.290000 8.18e-02 9.59e-02
Receptor Mediated Mitophagy 10 7.07e-02 1.23e-01 0.4190 NA -0.343000 -0.241000 6.05e-02 1.86e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 5.65e-02 1.06e-01 0.4190 NA -0.294000 0.298000 9.09e-02 8.76e-02
Nicotinate metabolism 19 7.01e-03 2.12e-02 0.4180 NA 0.189000 -0.373000 1.53e-01 4.89e-03
RHO GTPases Activate ROCKs 19 7.13e-03 2.13e-02 0.4180 NA -0.228000 0.350000 8.58e-02 8.22e-03
Downregulation of TGF-beta receptor signaling 26 1.11e-03 4.82e-03 0.4180 NA -0.409000 -0.086500 3.11e-04 4.45e-01
Unblocking of NMDA receptors, glutamate binding and activation 15 1.96e-02 4.61e-02 0.4170 NA 0.185000 0.374000 2.15e-01 1.21e-02
Influenza Infection 151 9.24e-18 5.32e-16 0.4170 NA -0.333000 -0.250000 1.59e-12 1.20e-07
Processing of Capped Intron-Containing Pre-mRNA 233 8.81e-27 2.79e-24 0.4160 NA -0.170000 -0.379000 8.27e-06 1.95e-23
O-glycosylation of TSR domain-containing proteins 22 3.34e-03 1.19e-02 0.4150 NA 0.165000 0.381000 1.79e-01 1.99e-03
Regulation of TP53 Activity through Acetylation 30 4.51e-04 2.34e-03 0.4130 NA -0.383000 -0.156000 2.85e-04 1.39e-01
Influenza Viral RNA Transcription and Replication 131 2.91e-15 9.93e-14 0.4130 NA -0.304000 -0.279000 1.81e-09 3.60e-08
Role of LAT2/NTAL/LAB on calcium mobilization 11 6.08e-02 1.12e-01 0.4130 NA -0.386000 0.148000 2.68e-02 3.97e-01
rRNA processing 218 8.66e-25 1.83e-22 0.4130 NA -0.242000 -0.335000 8.19e-10 1.79e-17
DAP12 interactions 22 3.76e-03 1.30e-02 0.4130 NA -0.253000 0.326000 4.01e-02 8.11e-03
Erythropoietin activates RAS 13 3.82e-02 7.78e-02 0.4100 NA -0.340000 0.230000 3.40e-02 1.50e-01
ERK/MAPK targets 21 5.26e-03 1.68e-02 0.4090 NA -0.332000 0.239000 8.40e-03 5.78e-02
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 17 1.41e-02 3.59e-02 0.4080 NA -0.331000 -0.238000 1.81e-02 8.90e-02
Carboxyterminal post-translational modifications of tubulin 28 9.12e-04 4.10e-03 0.4070 NA 0.249000 0.322000 2.25e-02 3.15e-03
PKA-mediated phosphorylation of CREB 15 2.47e-02 5.47e-02 0.4060 NA 0.022500 0.405000 8.80e-01 6.60e-03
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 30 6.00e-04 2.96e-03 0.4050 NA -0.289000 -0.285000 6.23e-03 7.00e-03
Negative regulation of MAPK pathway 39 7.08e-05 5.03e-04 0.4050 NA -0.388000 0.117000 2.76e-05 2.08e-01
Activation of the pre-replicative complex 32 3.84e-04 2.07e-03 0.4040 NA 0.355000 0.193000 5.12e-04 5.83e-02
SUMOylation of transcription cofactors 43 2.65e-05 2.21e-04 0.4040 NA -0.228000 -0.333000 9.57e-03 1.60e-04
Miscellaneous transport and binding events 22 5.01e-03 1.63e-02 0.4020 NA -0.307000 0.260000 1.27e-02 3.51e-02
Norepinephrine Neurotransmitter Release Cycle 13 4.35e-02 8.56e-02 0.4020 NA -0.131000 0.380000 4.12e-01 1.78e-02
Diseases associated with O-glycosylation of proteins 40 6.24e-05 4.51e-04 0.4020 NA 0.069400 0.396000 4.48e-01 1.49e-05
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 10 8.89e-02 1.50e-01 0.4010 NA 0.381000 0.125000 3.69e-02 4.94e-01
TRP channels 10 9.01e-02 1.51e-01 0.4000 NA 0.084900 0.391000 6.42e-01 3.22e-02
Telomere C-strand (Lagging Strand) Synthesis 24 3.08e-03 1.12e-02 0.4000 NA 0.359000 0.176000 2.32e-03 1.35e-01
Signaling by Insulin receptor 56 1.59e-06 1.98e-05 0.4000 NA -0.382000 0.119000 7.76e-07 1.24e-01
WNT5A-dependent internalization of FZD4 14 3.57e-02 7.39e-02 0.4000 NA -0.243000 0.318000 1.16e-01 3.97e-02
A tetrasaccharide linker sequence is required for GAG synthesis 24 3.20e-03 1.15e-02 0.3990 NA 0.150000 0.370000 2.02e-01 1.73e-03
Deadenylation of mRNA 25 2.55e-03 9.76e-03 0.3980 NA -0.192000 -0.349000 9.67e-02 2.52e-03
Polo-like kinase mediated events 16 2.28e-02 5.22e-02 0.3980 NA 0.248000 -0.311000 8.57e-02 3.11e-02
Cristae formation 13 4.52e-02 8.86e-02 0.3980 NA -0.233000 -0.322000 1.45e-01 4.44e-02
Signaling by EGFR in Cancer 21 7.15e-03 2.13e-02 0.3970 NA -0.380000 0.113000 2.55e-03 3.70e-01
TRAF6 mediated NF-kB activation 20 9.01e-03 2.56e-02 0.3960 NA -0.371000 -0.137000 4.05e-03 2.89e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 2.13e-04 1.26e-03 0.3950 NA -0.150000 -0.366000 1.19e-01 1.46e-04
MECP2 regulates neuronal receptors and channels 13 4.87e-02 9.42e-02 0.3950 NA -0.283000 0.275000 7.69e-02 8.60e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 45 2.65e-05 2.21e-04 0.3950 NA 0.146000 0.367000 9.05e-02 2.06e-05
Acetylcholine Neurotransmitter Release Cycle 10 9.69e-02 1.59e-01 0.3950 NA -0.009070 0.395000 9.60e-01 3.07e-02
Mitochondrial translation initiation 87 1.60e-09 3.17e-08 0.3940 NA -0.080800 -0.386000 1.93e-01 4.90e-10
Ion homeostasis 34 3.82e-04 2.07e-03 0.3940 NA -0.144000 0.367000 1.46e-01 2.16e-04
Signalling to ERKs 29 1.22e-03 5.22e-03 0.3940 NA -0.379000 0.108000 4.19e-04 3.14e-01
p75NTR signals via NF-kB 15 3.11e-02 6.64e-02 0.3920 NA -0.357000 -0.163000 1.67e-02 2.76e-01
Nuclear Events (kinase and transcription factor activation) 24 4.11e-03 1.39e-02 0.3920 NA -0.354000 0.167000 2.66e-03 1.56e-01
Acyl chain remodelling of PE 16 2.48e-02 5.49e-02 0.3920 NA 0.290000 0.263000 4.47e-02 6.84e-02
Degradation of cysteine and homocysteine 12 6.38e-02 1.15e-01 0.3910 NA 0.391000 0.013900 1.91e-02 9.33e-01
Processing of SMDT1 15 3.26e-02 6.93e-02 0.3900 NA -0.091400 -0.379000 5.40e-01 1.11e-02
DAG and IP3 signaling 31 8.87e-04 4.03e-03 0.3890 NA -0.042600 0.387000 6.82e-01 1.92e-04
CDC6 association with the ORC:origin complex 11 8.13e-02 1.39e-01 0.3890 NA 0.249000 0.299000 1.52e-01 8.63e-02
RHO GTPases activate PAKs 21 9.05e-03 2.56e-02 0.3880 NA -0.248000 0.298000 4.91e-02 1.81e-02
CD28 dependent PI3K/Akt signaling 18 1.73e-02 4.19e-02 0.3880 NA -0.386000 -0.032600 4.56e-03 8.11e-01
Activated NOTCH1 Transmits Signal to the Nucleus 28 1.92e-03 7.68e-03 0.3870 NA -0.279000 0.268000 1.06e-02 1.40e-02
Nephrin family interactions 21 9.20e-03 2.57e-02 0.3870 NA -0.277000 0.270000 2.78e-02 3.22e-02
Regulation of expression of SLITs and ROBOs 156 6.72e-16 2.74e-14 0.3870 NA -0.309000 -0.232000 2.65e-11 5.65e-07
CRMPs in Sema3A signaling 16 2.78e-02 6.03e-02 0.3860 NA 0.027600 0.385000 8.48e-01 7.60e-03
Mitochondrial translation elongation 87 3.68e-09 6.84e-08 0.3860 NA -0.097500 -0.374000 1.16e-01 1.72e-09
Signalling to RAS 18 1.82e-02 4.37e-02 0.3860 NA -0.373000 0.098800 6.16e-03 4.68e-01
HDR through Single Strand Annealing (SSA) 35 4.05e-04 2.13e-03 0.3860 NA 0.372000 0.101000 1.39e-04 3.02e-01
Mitochondrial translation termination 87 3.90e-09 7.05e-08 0.3850 NA -0.105000 -0.371000 9.09e-02 2.24e-09
ABC transporters in lipid homeostasis 15 3.51e-02 7.29e-02 0.3850 NA 0.192000 0.334000 1.97e-01 2.53e-02
FCERI mediated MAPK activation 24 4.96e-03 1.62e-02 0.3850 NA -0.345000 0.171000 3.45e-03 1.47e-01
SHC1 events in ERBB4 signaling 11 8.91e-02 1.50e-01 0.3840 NA -0.189000 0.334000 2.77e-01 5.52e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 4.59e-02 8.99e-02 0.3840 NA -0.063100 0.378000 6.83e-01 1.43e-02
Condensation of Prometaphase Chromosomes 11 9.05e-02 1.51e-01 0.3830 NA 0.222000 -0.312000 2.03e-01 7.32e-02
Nuclear import of Rev protein 33 7.10e-04 3.35e-03 0.3830 NA -0.096500 -0.370000 3.38e-01 2.33e-04
Regulation of necroptotic cell death 13 5.81e-02 1.08e-01 0.3820 NA -0.032400 -0.381000 8.40e-01 1.75e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 24 5.43e-03 1.71e-02 0.3820 NA -0.243000 0.295000 3.94e-02 1.25e-02
Loss of function of MECP2 in Rett syndrome 11 9.11e-02 1.52e-01 0.3820 NA -0.374000 0.077700 3.19e-02 6.55e-01
Pervasive developmental disorders 11 9.11e-02 1.52e-01 0.3820 NA -0.374000 0.077700 3.19e-02 6.55e-01
Dectin-2 family 13 5.93e-02 1.10e-01 0.3810 NA -0.138000 0.355000 3.88e-01 2.65e-02
Nuclear Receptor transcription pathway 42 1.08e-04 7.16e-04 0.3800 NA -0.317000 -0.209000 3.72e-04 1.89e-02
Activation of gene expression by SREBF (SREBP) 42 1.23e-04 7.92e-04 0.3790 NA 0.312000 -0.216000 4.75e-04 1.52e-02
Regulation of TP53 Activity through Methylation 18 2.06e-02 4.83e-02 0.3790 NA -0.152000 -0.347000 2.64e-01 1.09e-02
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 35 5.97e-04 2.96e-03 0.3770 NA 0.250000 -0.283000 1.05e-02 3.79e-03
InlB-mediated entry of Listeria monocytogenes into host cell 13 6.45e-02 1.16e-01 0.3760 NA -0.331000 0.178000 3.87e-02 2.66e-01
CaM pathway 25 5.11e-03 1.65e-02 0.3750 NA -0.000443 0.375000 9.97e-01 1.16e-03
Calmodulin induced events 25 5.11e-03 1.65e-02 0.3750 NA -0.000443 0.375000 9.97e-01 1.16e-03
Interactions of Rev with host cellular proteins 36 4.96e-04 2.56e-03 0.3750 NA -0.079200 -0.367000 4.11e-01 1.40e-04
Assembly Of The HIV Virion 16 3.40e-02 7.10e-02 0.3750 NA -0.283000 -0.245000 4.97e-02 8.98e-02
FRS-mediated FGFR1 signaling 12 8.17e-02 1.40e-01 0.3740 NA -0.267000 0.262000 1.09e-01 1.17e-01
Post-chaperonin tubulin folding pathway 20 1.48e-02 3.72e-02 0.3740 NA 0.313000 0.205000 1.55e-02 1.12e-01
Amino acid transport across the plasma membrane 28 2.82e-03 1.05e-02 0.3740 NA -0.370000 -0.055400 7.09e-04 6.12e-01
HS-GAG degradation 20 1.50e-02 3.75e-02 0.3740 NA 0.230000 0.295000 7.54e-02 2.26e-02
Acyl chain remodelling of PS 12 8.06e-02 1.38e-01 0.3730 NA 0.221000 0.301000 1.85e-01 7.14e-02
PI-3K cascade:FGFR1 10 1.26e-01 1.97e-01 0.3730 NA -0.335000 0.164000 6.69e-02 3.70e-01
Chromatin modifying enzymes 205 3.66e-19 2.77e-17 0.3730 NA -0.209000 -0.309000 2.72e-07 2.69e-14
Chromatin organization 205 3.66e-19 2.77e-17 0.3730 NA -0.209000 -0.309000 2.72e-07 2.69e-14
NCAM signaling for neurite out-growth 41 1.97e-04 1.18e-03 0.3730 NA 0.069400 0.366000 4.42e-01 5.02e-05
Glutathione conjugation 28 3.07e-03 1.12e-02 0.3720 NA 0.343000 -0.145000 1.69e-03 1.85e-01
Signaling by NTRK1 (TRKA) 68 8.03e-07 1.08e-05 0.3720 NA -0.356000 0.108000 3.85e-07 1.23e-01
Ca-dependent events 26 4.63e-03 1.53e-02 0.3720 NA -0.027800 0.371000 8.06e-01 1.07e-03
FRS-mediated FGFR2 signaling 12 8.42e-02 1.43e-01 0.3710 NA -0.116000 0.353000 4.85e-01 3.44e-02
Negative regulation of NMDA receptor-mediated neuronal transmission 18 2.39e-02 5.37e-02 0.3710 NA 0.170000 0.330000 2.11e-01 1.54e-02
tRNA modification in the nucleus and cytosol 41 2.17e-04 1.28e-03 0.3710 NA 0.046100 -0.368000 6.09e-01 4.54e-05
Activation of SMO 13 7.05e-02 1.23e-01 0.3700 NA -0.130000 0.346000 4.16e-01 3.09e-02
Negative regulation of FGFR4 signaling 21 1.39e-02 3.54e-02 0.3690 NA -0.367000 0.036900 3.59e-03 7.70e-01
ZBP1(DAI) mediated induction of type I IFNs 18 2.55e-02 5.63e-02 0.3690 NA -0.368000 -0.012600 6.81e-03 9.26e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 9.13e-03 2.57e-02 0.3680 NA -0.295000 -0.220000 1.42e-02 6.80e-02
Negative regulation of FGFR1 signaling 21 1.43e-02 3.61e-02 0.3680 NA -0.358000 0.087300 4.57e-03 4.89e-01
LDL clearance 19 2.16e-02 5.03e-02 0.3680 NA -0.318000 0.184000 1.63e-02 1.65e-01
Activation of RAC1 11 1.08e-01 1.74e-01 0.3680 NA -0.361000 0.070800 3.82e-02 6.84e-01
Mitochondrial translation 93 6.57e-09 1.15e-07 0.3680 NA -0.105000 -0.353000 8.05e-02 4.24e-09
PERK regulates gene expression 29 2.79e-03 1.05e-02 0.3670 NA -0.283000 -0.234000 8.41e-03 2.92e-02
Metabolism of RNA 676 2.86e-58 3.61e-55 0.3670 NA -0.170000 -0.325000 6.05e-14 7.01e-47
Adrenaline,noradrenaline inhibits insulin secretion 19 2.31e-02 5.27e-02 0.3650 NA -0.141000 0.336000 2.87e-01 1.12e-02
Cardiac conduction 77 2.53e-07 3.67e-06 0.3640 NA -0.087400 0.353000 1.85e-01 8.45e-08
AMER1 mutants destabilize the destruction complex 14 6.20e-02 1.12e-01 0.3640 NA -0.357000 -0.069600 2.08e-02 6.52e-01
APC truncation mutants have impaired AXIN binding 14 6.20e-02 1.12e-01 0.3640 NA -0.357000 -0.069600 2.08e-02 6.52e-01
AXIN missense mutants destabilize the destruction complex 14 6.20e-02 1.12e-01 0.3640 NA -0.357000 -0.069600 2.08e-02 6.52e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 6.20e-02 1.12e-01 0.3640 NA -0.357000 -0.069600 2.08e-02 6.52e-01
Truncations of AMER1 destabilize the destruction complex 14 6.20e-02 1.12e-01 0.3640 NA -0.357000 -0.069600 2.08e-02 6.52e-01
truncated APC mutants destabilize the destruction complex 14 6.20e-02 1.12e-01 0.3640 NA -0.357000 -0.069600 2.08e-02 6.52e-01
Synthesis, secretion, and deacylation of Ghrelin 10 1.39e-01 2.14e-01 0.3630 NA -0.349000 0.102000 5.63e-02 5.76e-01
PKA activation in glucagon signalling 14 6.31e-02 1.14e-01 0.3630 NA 0.028200 0.362000 8.55e-01 1.91e-02
Spry regulation of FGF signaling 16 4.28e-02 8.48e-02 0.3630 NA -0.362000 0.010300 1.21e-02 9.43e-01
Prolonged ERK activation events 10 1.40e-01 2.16e-01 0.3620 NA -0.350000 0.095700 5.56e-02 6.00e-01
Intrinsic Pathway of Fibrin Clot Formation 18 2.95e-02 6.36e-02 0.3620 NA 0.243000 -0.268000 7.39e-02 4.86e-02
COPII-mediated vesicle transport 63 4.53e-06 5.12e-05 0.3620 NA -0.350000 0.091500 1.54e-06 2.10e-01
Assembly and cell surface presentation of NMDA receptors 22 1.35e-02 3.48e-02 0.3610 NA 0.186000 0.309000 1.31e-01 1.22e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 4.45e-02 8.75e-02 0.3600 NA -0.360000 0.007920 1.26e-02 9.56e-01
SUMOylation of immune response proteins 11 1.16e-01 1.85e-01 0.3600 NA -0.288000 -0.216000 9.79e-02 2.15e-01
G-protein activation 16 4.51e-02 8.85e-02 0.3600 NA -0.149000 0.328000 3.03e-01 2.31e-02
Nicotinamide salvaging 10 1.45e-01 2.21e-01 0.3600 NA 0.245000 -0.264000 1.81e-01 1.48e-01
PI-3K cascade:FGFR4 10 1.45e-01 2.21e-01 0.3590 NA -0.355000 0.058100 5.21e-02 7.51e-01
Synthesis of PIPs at the early endosome membrane 15 5.55e-02 1.05e-01 0.3590 NA -0.313000 0.177000 3.59e-02 2.36e-01
Class B/2 (Secretin family receptors) 47 1.18e-04 7.70e-04 0.3580 NA 0.025100 0.358000 7.66e-01 2.22e-05
FRS-mediated FGFR3 signaling 11 1.22e-01 1.93e-01 0.3580 NA -0.239000 0.267000 1.70e-01 1.25e-01
Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD 53 3.75e-05 2.96e-04 0.3580 NA -0.332000 -0.133000 2.88e-05 9.39e-02
RET signaling 33 1.85e-03 7.43e-03 0.3580 NA -0.328000 0.143000 1.12e-03 1.56e-01
Physiological factors 11 1.24e-01 1.95e-01 0.3570 NA -0.282000 0.218000 1.05e-01 2.11e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 13 8.49e-02 1.44e-01 0.3570 NA 0.180000 -0.308000 2.60e-01 5.49e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 26 7.03e-03 2.12e-02 0.3560 NA -0.085000 -0.346000 4.53e-01 2.26e-03
Negative regulation of FGFR3 signaling 20 2.28e-02 5.22e-02 0.3560 NA -0.346000 0.081600 7.36e-03 5.27e-01
O-linked glycosylation of mucins 39 6.68e-04 3.19e-03 0.3540 NA -0.080300 0.345000 3.86e-01 1.93e-04
Elevation of cytosolic Ca2+ levels 10 1.55e-01 2.33e-01 0.3540 NA -0.217000 0.279000 2.35e-01 1.26e-01
Role of phospholipids in phagocytosis 15 6.11e-02 1.12e-01 0.3530 NA -0.139000 0.325000 3.52e-01 2.94e-02
Incretin synthesis, secretion, and inactivation 13 8.94e-02 1.50e-01 0.3520 NA -0.344000 0.076500 3.17e-02 6.33e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 1.56e-01 2.34e-01 0.3520 NA -0.002350 0.352000 9.90e-01 5.38e-02
Peroxisomal protein import 58 2.24e-05 1.93e-04 0.3520 NA 0.202000 -0.289000 7.95e-03 1.43e-04
The role of Nef in HIV-1 replication and disease pathogenesis 23 1.43e-02 3.61e-02 0.3520 NA -0.159000 0.314000 1.88e-01 9.09e-03
Retrograde neurotrophin signalling 10 1.58e-01 2.36e-01 0.3520 NA -0.204000 0.287000 2.65e-01 1.16e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 19 3.04e-02 6.53e-02 0.3510 NA -0.142000 0.321000 2.84e-01 1.54e-02
Recycling pathway of L1 22 1.77e-02 4.26e-02 0.3510 NA -0.249000 0.247000 4.34e-02 4.46e-02
Chondroitin sulfate biosynthesis 19 3.05e-02 6.53e-02 0.3510 NA -0.090600 0.339000 4.94e-01 1.06e-02
Hh mutants abrogate ligand secretion 55 3.99e-05 3.07e-04 0.3500 NA -0.325000 -0.131000 3.08e-05 9.34e-02
trans-Golgi Network Vesicle Budding 69 3.85e-06 4.43e-05 0.3480 NA -0.330000 0.112000 2.17e-06 1.08e-01
FOXO-mediated transcription of cell cycle genes 15 6.68e-02 1.18e-01 0.3470 NA -0.334000 0.097300 2.53e-02 5.14e-01
Mitophagy 25 1.10e-02 2.99e-02 0.3460 NA -0.300000 -0.173000 9.43e-03 1.35e-01
Transport of Mature mRNA Derived from an Intronless Transcript 41 6.40e-04 3.09e-03 0.3460 NA -0.047300 -0.343000 6.01e-01 1.47e-04
Regulation of PTEN stability and activity 65 8.76e-06 9.01e-05 0.3450 NA -0.294000 -0.181000 4.14e-05 1.16e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 4.72e-02 9.19e-02 0.3450 NA -0.218000 -0.268000 1.20e-01 5.56e-02
Rev-mediated nuclear export of HIV RNA 34 2.32e-03 9.06e-03 0.3450 NA -0.047400 -0.342000 6.33e-01 5.65e-04
Signaling by FGFR3 31 4.08e-03 1.39e-02 0.3450 NA -0.326000 0.111000 1.66e-03 2.84e-01
Defective CFTR causes cystic fibrosis 56 4.79e-05 3.59e-04 0.3440 NA -0.319000 -0.129000 3.68e-05 9.51e-02
Glutamate Neurotransmitter Release Cycle 17 5.02e-02 9.67e-02 0.3430 NA -0.099400 0.329000 4.78e-01 1.90e-02
Ras activation upon Ca2+ influx through NMDA receptor 19 3.50e-02 7.28e-02 0.3430 NA 0.065000 0.337000 6.24e-01 1.11e-02
COPI-mediated anterograde transport 77 1.42e-06 1.80e-05 0.3420 NA -0.341000 0.032600 2.37e-07 6.21e-01
Degradation of AXIN 52 1.06e-04 7.11e-04 0.3420 NA -0.279000 -0.197000 4.92e-04 1.38e-02
Circadian Clock 67 7.80e-06 8.29e-05 0.3420 NA -0.278000 -0.199000 8.38e-05 4.87e-03
Serotonin Neurotransmitter Release Cycle 12 1.22e-01 1.94e-01 0.3420 NA 0.016900 0.341000 9.19e-01 4.07e-02
Semaphorin interactions 57 5.02e-05 3.71e-04 0.3420 NA -0.174000 0.294000 2.30e-02 1.25e-04
FOXO-mediated transcription of cell death genes 15 7.23e-02 1.25e-01 0.3410 NA -0.309000 -0.145000 3.85e-02 3.30e-01
Opioid Signalling 64 1.55e-05 1.40e-04 0.3410 NA -0.143000 0.310000 4.87e-02 1.84e-05
HDR through Homologous Recombination (HRR) 63 1.73e-05 1.54e-04 0.3410 NA 0.330000 0.083800 5.82e-06 2.50e-01
Extension of Telomeres 30 5.35e-03 1.69e-02 0.3410 NA 0.321000 0.115000 2.37e-03 2.75e-01
SUMOylation of RNA binding proteins 46 3.46e-04 1.93e-03 0.3400 NA -0.012000 -0.340000 8.88e-01 6.64e-05
MyD88 cascade initiated on plasma membrane 77 1.88e-06 2.24e-05 0.3390 NA -0.338000 0.028300 3.07e-07 6.68e-01
Toll Like Receptor 10 (TLR10) Cascade 77 1.88e-06 2.24e-05 0.3390 NA -0.338000 0.028300 3.07e-07 6.68e-01
Toll Like Receptor 5 (TLR5) Cascade 77 1.88e-06 2.24e-05 0.3390 NA -0.338000 0.028300 3.07e-07 6.68e-01
mTORC1-mediated signalling 23 1.90e-02 4.50e-02 0.3380 NA -0.296000 -0.164000 1.40e-02 1.74e-01
CD28 co-stimulation 27 1.01e-02 2.77e-02 0.3380 NA -0.331000 0.067400 2.93e-03 5.45e-01
Downstream signaling of activated FGFR3 16 6.61e-02 1.18e-01 0.3380 NA -0.270000 0.202000 6.14e-02 1.61e-01
Diseases associated with glycosaminoglycan metabolism 34 2.97e-03 1.09e-02 0.3370 NA 0.125000 0.313000 2.06e-01 1.57e-03
Purine ribonucleoside monophosphate biosynthesis 12 1.30e-01 2.03e-01 0.3370 NA 0.124000 -0.313000 4.55e-01 6.02e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 19 4.03e-02 8.12e-02 0.3370 NA 0.240000 -0.236000 7.01e-02 7.46e-02
Signaling by FGFR4 31 5.32e-03 1.69e-02 0.3360 NA -0.330000 0.063700 1.47e-03 5.40e-01
NEP/NS2 Interacts with the Cellular Export Machinery 31 5.25e-03 1.68e-02 0.3360 NA -0.058300 -0.331000 5.74e-01 1.43e-03
MAP kinase activation 61 3.44e-05 2.79e-04 0.3360 NA -0.334000 0.036000 6.47e-06 6.27e-01
Gap junction trafficking 15 7.96e-02 1.37e-01 0.3350 NA 0.055500 0.331000 7.10e-01 2.66e-02
Synthesis of very long-chain fatty acyl-CoAs 18 4.78e-02 9.31e-02 0.3350 NA 0.218000 0.254000 1.10e-01 6.17e-02
EPHA-mediated growth cone collapse 15 8.23e-02 1.40e-01 0.3340 NA -0.165000 0.291000 2.69e-01 5.14e-02
EGFR downregulation 25 1.54e-02 3.84e-02 0.3340 NA -0.330000 0.053500 4.32e-03 6.44e-01
Hedgehog ligand biogenesis 60 4.37e-05 3.31e-04 0.3340 NA -0.316000 -0.109000 2.34e-05 1.45e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 5.83e-02 1.09e-01 0.3330 NA -0.240000 -0.231000 8.68e-02 9.91e-02
FRS-mediated FGFR4 signaling 12 1.37e-01 2.12e-01 0.3330 NA -0.284000 0.174000 8.83e-02 2.98e-01
Transport of Ribonucleoproteins into the Host Nucleus 31 5.80e-03 1.80e-02 0.3330 NA -0.080900 -0.323000 4.36e-01 1.88e-03
Gamma carboxylation, hypusine formation and arylsulfatase activation 34 3.62e-03 1.28e-02 0.3320 NA 0.009360 -0.332000 9.25e-01 8.02e-04
EPH-ephrin mediated repulsion of cells 41 1.20e-03 5.19e-03 0.3320 NA -0.107000 0.314000 2.36e-01 5.09e-04
Downstream signaling of activated FGFR4 17 6.16e-02 1.12e-01 0.3310 NA -0.300000 0.140000 3.20e-02 3.18e-01
EPH-Ephrin signaling 84 1.12e-06 1.45e-05 0.3310 NA -0.207000 0.259000 1.05e-03 4.13e-05
Transport of inorganic cations/anions and amino acids/oligopeptides 72 8.10e-06 8.40e-05 0.3310 NA -0.291000 0.158000 1.99e-05 2.07e-02
Regulation of KIT signaling 15 8.78e-02 1.48e-01 0.3300 NA -0.154000 0.291000 3.01e-01 5.08e-02
Asparagine N-linked glycosylation 259 8.27e-19 5.51e-17 0.3300 NA -0.330000 -0.001560 7.17e-20 9.66e-01
ER to Golgi Anterograde Transport 126 1.57e-09 3.14e-08 0.3290 NA -0.324000 0.054300 3.26e-10 2.93e-01
Interleukin-12 signaling 37 2.45e-03 9.41e-03 0.3290 NA -0.288000 -0.159000 2.45e-03 9.46e-02
Nuclear Pore Complex (NPC) Disassembly 35 3.60e-03 1.27e-02 0.3280 NA 0.056300 -0.323000 5.65e-01 9.40e-04
Initiation of Nuclear Envelope Reformation 13 1.24e-01 1.95e-01 0.3260 NA -0.139000 -0.296000 3.87e-01 6.50e-02
Nuclear Envelope Reassembly 13 1.24e-01 1.95e-01 0.3260 NA -0.139000 -0.296000 3.87e-01 6.50e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 42 1.23e-03 5.24e-03 0.3260 NA -0.066600 -0.319000 4.55e-01 3.43e-04
Signaling by FGFR3 fusions in cancer 10 2.04e-01 2.91e-01 0.3260 NA -0.325000 0.019200 7.49e-02 9.16e-01
Platelet calcium homeostasis 19 4.97e-02 9.60e-02 0.3250 NA -0.132000 0.298000 3.21e-01 2.48e-02
TBC/RABGAPs 43 1.21e-03 5.19e-03 0.3240 NA -0.293000 0.137000 8.79e-04 1.19e-01
Trafficking of GluR2-containing AMPA receptors 13 1.31e-01 2.04e-01 0.3240 NA -0.123000 0.299000 4.41e-01 6.16e-02
Activation of NF-kappaB in B cells 63 4.93e-05 3.67e-04 0.3240 NA -0.288000 -0.149000 7.93e-05 4.11e-02
Misspliced GSK3beta mutants stabilize beta-catenin 15 9.43e-02 1.55e-01 0.3240 NA -0.311000 -0.089700 3.71e-02 5.47e-01
S33 mutants of beta-catenin aren’t phosphorylated 15 9.43e-02 1.55e-01 0.3240 NA -0.311000 -0.089700 3.71e-02 5.47e-01
S37 mutants of beta-catenin aren’t phosphorylated 15 9.43e-02 1.55e-01 0.3240 NA -0.311000 -0.089700 3.71e-02 5.47e-01
S45 mutants of beta-catenin aren’t phosphorylated 15 9.43e-02 1.55e-01 0.3240 NA -0.311000 -0.089700 3.71e-02 5.47e-01
T41 mutants of beta-catenin aren’t phosphorylated 15 9.43e-02 1.55e-01 0.3240 NA -0.311000 -0.089700 3.71e-02 5.47e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 9.43e-02 1.55e-01 0.3240 NA -0.311000 -0.089700 3.71e-02 5.47e-01
Synthesis of IP3 and IP4 in the cytosol 21 3.83e-02 7.79e-02 0.3230 NA -0.226000 0.231000 7.33e-02 6.72e-02
Interleukin-17 signaling 65 4.04e-05 3.09e-04 0.3230 NA -0.322000 0.024200 7.21e-06 7.36e-01
Downstream signaling of activated FGFR2 17 7.14e-02 1.24e-01 0.3230 NA -0.182000 0.267000 1.94e-01 5.71e-02
SUMOylation of ubiquitinylation proteins 38 2.63e-03 1.00e-02 0.3230 NA -0.092900 -0.309000 3.22e-01 9.82e-04
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 28 1.29e-02 3.37e-02 0.3230 NA -0.114000 0.302000 2.97e-01 5.70e-03
Degradation of DVL 52 2.93e-04 1.68e-03 0.3230 NA -0.244000 -0.211000 2.33e-03 8.54e-03
CS/DS degradation 13 1.33e-01 2.06e-01 0.3220 NA -0.109000 0.303000 4.98e-01 5.82e-02
mTOR signalling 39 2.29e-03 8.98e-03 0.3220 NA -0.233000 -0.222000 1.18e-02 1.65e-02
Adherens junctions interactions 14 1.13e-01 1.80e-01 0.3220 NA 0.252000 0.200000 1.02e-01 1.95e-01
Interleukin receptor SHC signaling 18 6.24e-02 1.13e-01 0.3210 NA -0.315000 0.060200 2.06e-02 6.58e-01
Establishment of Sister Chromatid Cohesion 10 2.15e-01 3.04e-01 0.3210 NA 0.098800 -0.305000 5.88e-01 9.48e-02
RIPK1-mediated regulated necrosis 15 9.91e-02 1.61e-01 0.3210 NA 0.002100 -0.321000 9.89e-01 3.15e-02
Regulated Necrosis 15 9.91e-02 1.61e-01 0.3210 NA 0.002100 -0.321000 9.89e-01 3.15e-02
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 80 4.78e-06 5.35e-05 0.3200 NA -0.320000 0.014800 7.58e-07 8.19e-01
Processing of Intronless Pre-mRNAs 19 5.48e-02 1.04e-01 0.3190 NA -0.018600 -0.319000 8.89e-01 1.62e-02
Golgi Associated Vesicle Biogenesis 55 2.46e-04 1.43e-03 0.3180 NA -0.300000 0.106000 1.18e-04 1.75e-01
SUMOylation of intracellular receptors 27 1.64e-02 4.03e-02 0.3180 NA -0.262000 -0.181000 1.86e-02 1.04e-01
APC-Cdc20 mediated degradation of Nek2A 25 2.32e-02 5.29e-02 0.3180 NA 0.219000 -0.231000 5.84e-02 4.59e-02
CTLA4 inhibitory signaling 18 6.64e-02 1.18e-01 0.3180 NA -0.289000 0.131000 3.36e-02 3.35e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 24 2.64e-02 5.79e-02 0.3180 NA 0.038700 0.315000 7.43e-01 7.50e-03
Trafficking of AMPA receptors 24 2.64e-02 5.79e-02 0.3180 NA 0.038700 0.315000 7.43e-01 7.50e-03
Peroxisomal lipid metabolism 25 2.39e-02 5.37e-02 0.3170 NA 0.254000 -0.189000 2.79e-02 1.02e-01
Signaling by FGFR1 36 4.62e-03 1.53e-02 0.3170 NA -0.290000 0.128000 2.63e-03 1.86e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 30 1.12e-02 3.02e-02 0.3160 NA 0.009760 -0.316000 9.26e-01 2.74e-03
Regulation of Glucokinase by Glucokinase Regulatory Protein 30 1.12e-02 3.02e-02 0.3160 NA 0.009760 -0.316000 9.26e-01 2.74e-03
Downstream signaling of activated FGFR1 19 5.90e-02 1.09e-01 0.3160 NA -0.210000 0.236000 1.13e-01 7.48e-02
Glycogen storage diseases 14 1.24e-01 1.95e-01 0.3160 NA 0.135000 -0.286000 3.83e-01 6.41e-02
Neurotransmitter receptors and postsynaptic signal transmission 118 2.47e-08 3.95e-07 0.3150 NA 0.028900 0.314000 5.88e-01 3.83e-09
Transport to the Golgi and subsequent modification 150 2.54e-10 5.54e-09 0.3150 NA -0.312000 0.040600 4.21e-11 3.91e-01
Regulation of insulin secretion 53 4.02e-04 2.13e-03 0.3140 NA -0.066800 0.307000 4.00e-01 1.10e-04
Signaling by ROBO receptors 195 3.41e-13 1.05e-11 0.3140 NA -0.277000 -0.149000 2.73e-11 3.54e-04
O-linked glycosylation 68 4.54e-05 3.42e-04 0.3140 NA -0.008960 0.314000 8.98e-01 7.78e-06
APC/C:Cdc20 mediated degradation of Cyclin B 23 3.43e-02 7.14e-02 0.3140 NA 0.162000 -0.268000 1.78e-01 2.58e-02
Reversible hydration of carbon dioxide 10 2.28e-01 3.20e-01 0.3140 NA 0.083700 0.302000 6.47e-01 9.80e-02
Mitochondrial protein import 58 1.93e-04 1.16e-03 0.3140 NA -0.096300 -0.298000 2.05e-01 8.52e-05
Transport of the SLBP independent Mature mRNA 34 6.66e-03 2.03e-02 0.3140 NA -0.049400 -0.310000 6.18e-01 1.79e-03
PI-3K cascade:FGFR2 10 2.31e-01 3.24e-01 0.3130 NA -0.153000 0.273000 4.01e-01 1.35e-01
CD209 (DC-SIGN) signaling 19 6.27e-02 1.13e-01 0.3130 NA -0.260000 0.174000 4.99e-02 1.89e-01
Autodegradation of the E3 ubiquitin ligase COP1 49 7.48e-04 3.51e-03 0.3130 NA -0.242000 -0.197000 3.33e-03 1.70e-02
The canonical retinoid cycle in rods (twilight vision) 15 1.10e-01 1.77e-01 0.3120 NA 0.194000 0.245000 1.93e-01 1.01e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 47 1.02e-03 4.50e-03 0.3120 NA -0.256000 -0.178000 2.36e-03 3.49e-02
Macroautophagy 84 4.82e-06 5.35e-05 0.3120 NA -0.305000 -0.066800 1.38e-06 2.90e-01
Assembly of collagen fibrils and other multimeric structures 36 5.17e-03 1.66e-02 0.3120 NA 0.221000 0.220000 2.19e-02 2.24e-02
Acyl chain remodelling of PC 18 7.19e-02 1.25e-01 0.3120 NA 0.231000 0.209000 8.96e-02 1.25e-01
Toll Like Receptor 9 (TLR9) Cascade 84 5.29e-06 5.77e-05 0.3110 NA -0.311000 0.018100 8.54e-07 7.75e-01
Endosomal/Vacuolar pathway 12 1.74e-01 2.55e-01 0.3110 NA 0.162000 0.266000 3.31e-01 1.11e-01
Iron uptake and transport 55 3.74e-04 2.04e-03 0.3100 NA -0.295000 0.095500 1.53e-04 2.21e-01
G alpha (q) signalling events 98 8.22e-07 1.09e-05 0.3100 NA -0.123000 0.285000 3.60e-02 1.11e-06
Signaling by EGFR 42 2.41e-03 9.33e-03 0.3100 NA -0.301000 0.073200 7.31e-04 4.12e-01
Transcriptional regulation of pluripotent stem cells 23 3.66e-02 7.52e-02 0.3100 NA -0.024800 0.309000 8.37e-01 1.03e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 10 2.39e-01 3.31e-01 0.3090 NA -0.297000 0.088300 1.04e-01 6.29e-01
MyD88 dependent cascade initiated on endosome 81 9.47e-06 9.43e-05 0.3090 NA -0.309000 0.018800 1.57e-06 7.70e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 81 9.47e-06 9.43e-05 0.3090 NA -0.309000 0.018800 1.57e-06 7.70e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 52 5.94e-04 2.96e-03 0.3080 NA -0.245000 -0.187000 2.27e-03 1.95e-02
Deadenylation-dependent mRNA decay 56 3.42e-04 1.92e-03 0.3080 NA -0.092800 -0.294000 2.30e-01 1.43e-04
RMTs methylate histone arginines 36 6.00e-03 1.85e-02 0.3080 NA -0.000170 -0.308000 9.99e-01 1.38e-03
Signaling by FGFR3 in disease 13 1.59e-01 2.37e-01 0.3080 NA -0.263000 0.159000 1.00e-01 3.20e-01
Signaling by FGFR3 point mutants in cancer 13 1.59e-01 2.37e-01 0.3080 NA -0.263000 0.159000 1.00e-01 3.20e-01
Vpr-mediated nuclear import of PICs 33 9.22e-03 2.57e-02 0.3080 NA -0.035300 -0.306000 7.26e-01 2.37e-03
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 51 7.35e-04 3.46e-03 0.3070 NA -0.246000 -0.183000 2.39e-03 2.35e-02
Muscle contraction 120 5.05e-08 7.61e-07 0.3070 NA -0.021800 0.306000 6.80e-01 7.29e-09
Insulin receptor signalling cascade 34 8.41e-03 2.45e-02 0.3060 NA -0.301000 -0.057400 2.42e-03 5.63e-01
Toll Like Receptor 3 (TLR3) Cascade 87 5.62e-06 6.08e-05 0.3050 NA -0.303000 0.035800 1.03e-06 5.64e-01
GPVI-mediated activation cascade 21 5.42e-02 1.03e-01 0.3050 NA -0.280000 0.122000 2.66e-02 3.33e-01
Negative regulation of FGFR2 signaling 21 5.44e-02 1.03e-01 0.3050 NA -0.271000 0.139000 3.15e-02 2.69e-01
Blood group systems biosynthesis 12 1.88e-01 2.72e-01 0.3050 NA 0.028400 -0.303000 8.65e-01 6.88e-02
Gastrin-CREB signalling pathway via PKC and MAPK 16 1.09e-01 1.75e-01 0.3050 NA -0.289000 0.097300 4.56e-02 5.01e-01
Ubiquitin-dependent degradation of Cyclin D 49 1.08e-03 4.73e-03 0.3050 NA -0.264000 -0.152000 1.39e-03 6.64e-02
Netrin-1 signaling 38 5.26e-03 1.68e-02 0.3040 NA -0.124000 0.278000 1.86e-01 3.03e-03
SUMOylation of SUMOylation proteins 34 9.07e-03 2.56e-02 0.3040 NA -0.040800 -0.301000 6.80e-01 2.39e-03
Export of Viral Ribonucleoproteins from Nucleus 32 1.21e-02 3.20e-02 0.3030 NA -0.030500 -0.302000 7.66e-01 3.13e-03
ABC transporter disorders 68 8.33e-05 5.78e-04 0.3030 NA -0.243000 -0.181000 5.31e-04 9.75e-03
Glyoxylate metabolism and glycine degradation 27 2.45e-02 5.47e-02 0.3030 NA 0.293000 -0.077700 8.39e-03 4.85e-01
ATF4 activates genes in response to endoplasmic reticulum stress 24 3.61e-02 7.46e-02 0.3030 NA -0.183000 -0.241000 1.20e-01 4.07e-02
Regulation of gene expression in beta cells 14 1.47e-01 2.23e-01 0.3030 NA 0.199000 -0.228000 1.97e-01 1.39e-01
Rap1 signalling 14 1.49e-01 2.25e-01 0.3020 NA -0.127000 0.274000 4.10e-01 7.59e-02
IRAK1 recruits IKK complex 10 2.57e-01 3.51e-01 0.3020 NA -0.235000 0.189000 1.97e-01 3.00e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 2.57e-01 3.51e-01 0.3020 NA -0.235000 0.189000 1.97e-01 3.00e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 12 1.95e-01 2.80e-01 0.3020 NA -0.297000 0.052000 7.47e-02 7.55e-01
Activation of BAD and translocation to mitochondria 15 1.30e-01 2.03e-01 0.3010 NA -0.298000 0.043000 4.54e-02 7.73e-01
RAB geranylgeranylation 54 6.83e-04 3.25e-03 0.3010 NA -0.187000 0.236000 1.75e-02 2.70e-03
G alpha (s) signalling events 68 1.03e-04 6.96e-04 0.3010 NA -0.074400 0.292000 2.89e-01 3.23e-05
Inactivation, recovery and regulation of the phototransduction cascade 20 6.84e-02 1.20e-01 0.3000 NA -0.110000 0.279000 3.94e-01 3.09e-02
UCH proteinases 85 1.07e-05 1.05e-04 0.3000 NA -0.252000 -0.162000 5.82e-05 1.01e-02
Sema4D in semaphorin signaling 24 4.07e-02 8.21e-02 0.2990 NA -0.196000 0.226000 9.59e-02 5.57e-02
Regulation of RUNX3 expression and activity 54 7.06e-04 3.34e-03 0.2990 NA -0.263000 -0.143000 8.49e-04 6.87e-02
Phase II - Conjugation of compounds 74 5.83e-05 4.24e-04 0.2980 NA 0.258000 -0.149000 1.27e-04 2.68e-02
Formation of the cornified envelope 20 6.98e-02 1.22e-01 0.2980 NA -0.113000 -0.275000 3.82e-01 3.31e-02
PTEN Regulation 136 1.58e-08 2.62e-07 0.2970 NA -0.239000 -0.176000 1.49e-06 3.91e-04
Cyclin A/B1/B2 associated events during G2/M transition 24 4.25e-02 8.45e-02 0.2970 NA 0.274000 -0.114000 2.00e-02 3.34e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 3.26e-02 6.92e-02 0.2960 NA -0.291000 -0.055700 1.02e-02 6.23e-01
p75NTR recruits signalling complexes 12 2.06e-01 2.95e-01 0.2960 NA -0.296000 -0.011500 7.60e-02 9.45e-01
RNA Polymerase III Transcription Termination 23 4.83e-02 9.38e-02 0.2960 NA -0.252000 -0.155000 3.66e-02 1.97e-01
RHO GTPases activate KTN1 11 2.38e-01 3.30e-01 0.2960 NA -0.273000 0.113000 1.17e-01 5.16e-01
Downstream TCR signaling 77 4.10e-05 3.12e-04 0.2960 NA -0.269000 -0.122000 4.44e-05 6.34e-02
DARPP-32 events 22 5.69e-02 1.07e-01 0.2960 NA -0.236000 0.178000 5.52e-02 1.49e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 86 1.29e-05 1.22e-04 0.2950 NA -0.223000 -0.194000 3.61e-04 1.88e-03
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 1.83e-01 2.65e-01 0.2950 NA -0.295000 0.017100 6.58e-02 9.15e-01
Signaling by FGFR4 in disease 11 2.39e-01 3.31e-01 0.2950 NA -0.295000 -0.006960 9.06e-02 9.68e-01
Dectin-1 mediated noncanonical NF-kB signaling 57 5.94e-04 2.96e-03 0.2950 NA -0.262000 -0.135000 6.32e-04 7.78e-02
Elastic fibre formation 29 2.27e-02 5.22e-02 0.2940 NA 0.147000 0.255000 1.71e-01 1.74e-02
Ion transport by P-type ATPases 37 8.38e-03 2.45e-02 0.2940 NA -0.079600 0.283000 4.02e-01 2.87e-03
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 31 1.84e-02 4.39e-02 0.2940 NA -0.276000 0.101000 7.78e-03 3.32e-01
Biosynthesis of specialized proresolving mediators (SPMs) 11 2.40e-01 3.33e-01 0.2940 NA 0.076600 0.284000 6.60e-01 1.03e-01
Signaling by TGF-beta Receptor Complex 72 9.42e-05 6.44e-04 0.2930 NA -0.281000 -0.083100 3.74e-05 2.23e-01
Chondroitin sulfate/dermatan sulfate metabolism 47 2.43e-03 9.39e-03 0.2930 NA -0.016000 0.292000 8.49e-01 5.30e-04
Transport of the SLBP Dependant Mature mRNA 35 1.14e-02 3.06e-02 0.2920 NA -0.072600 -0.283000 4.58e-01 3.82e-03
Sema3A PAK dependent Axon repulsion 16 1.32e-01 2.05e-01 0.2910 NA -0.121000 0.265000 4.01e-01 6.68e-02
Beta-catenin phosphorylation cascade 17 1.15e-01 1.84e-01 0.2910 NA -0.278000 -0.084800 4.70e-02 5.45e-01
Pink/Parkin Mediated Mitophagy 18 1.02e-01 1.66e-01 0.2910 NA -0.287000 -0.044900 3.48e-02 7.42e-01
NIK–>noncanonical NF-kB signaling 56 8.20e-04 3.77e-03 0.2910 NA -0.259000 -0.131000 7.86e-04 9.00e-02
p38MAPK events 13 1.94e-01 2.79e-01 0.2910 NA -0.264000 0.122000 9.95e-02 4.47e-01
Signaling by Leptin 10 2.87e-01 3.81e-01 0.2890 NA 0.152000 -0.246000 4.04e-01 1.78e-01
PI3K Cascade 25 4.31e-02 8.52e-02 0.2890 NA -0.274000 -0.093100 1.78e-02 4.21e-01
Membrane binding and targetting of GAG proteins 14 1.71e-01 2.53e-01 0.2890 NA -0.232000 -0.172000 1.32e-01 2.65e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 1.71e-01 2.53e-01 0.2890 NA -0.232000 -0.172000 1.32e-01 2.65e-01
L1CAM interactions 78 6.43e-05 4.62e-04 0.2890 NA -0.140000 0.252000 3.25e-02 1.18e-04
MyD88-independent TLR4 cascade 90 1.42e-05 1.30e-04 0.2880 NA -0.287000 0.028700 2.56e-06 6.38e-01
TRIF(TICAM1)-mediated TLR4 signaling 90 1.42e-05 1.30e-04 0.2880 NA -0.287000 0.028700 2.56e-06 6.38e-01
Non-genomic estrogen signaling 57 8.73e-04 3.98e-03 0.2880 NA -0.273000 0.092800 3.73e-04 2.26e-01
Metabolism of non-coding RNA 52 1.59e-03 6.53e-03 0.2880 NA 0.026900 -0.287000 7.37e-01 3.49e-04
snRNP Assembly 52 1.59e-03 6.53e-03 0.2880 NA 0.026900 -0.287000 7.37e-01 3.49e-04
Downstream signaling events of B Cell Receptor (BCR) 77 7.37e-05 5.21e-04 0.2870 NA -0.281000 -0.061400 2.07e-05 3.52e-01
Protein methylation 15 1.57e-01 2.35e-01 0.2870 NA -0.003430 -0.287000 9.82e-01 5.43e-02
SCF-beta-TrCP mediated degradation of Emi1 52 1.60e-03 6.53e-03 0.2870 NA -0.225000 -0.179000 5.08e-03 2.60e-02
ADP signalling through P2Y purinoceptor 12 12 2.29e-01 3.21e-01 0.2870 NA -0.165000 0.235000 3.22e-01 1.59e-01
Biosynthesis of DHA-derived SPMs 10 2.90e-01 3.84e-01 0.2870 NA 0.166000 0.234000 3.64e-01 2.00e-01
Attenuation phase 23 5.87e-02 1.09e-01 0.2860 NA -0.269000 -0.098200 2.56e-02 4.15e-01
Signaling by NTRKs 84 3.66e-05 2.91e-04 0.2860 NA -0.276000 0.075100 1.26e-05 2.35e-01
E2F mediated regulation of DNA replication 22 6.71e-02 1.19e-01 0.2860 NA 0.267000 0.103000 3.05e-02 4.03e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 1.24e-01 1.95e-01 0.2860 NA -0.127000 -0.256000 3.66e-01 6.75e-02
Glutathione synthesis and recycling 12 2.33e-01 3.25e-01 0.2850 NA 0.277000 -0.068400 9.72e-02 6.82e-01
Regulation of actin dynamics for phagocytic cup formation 50 2.39e-03 9.26e-03 0.2850 NA -0.275000 0.073600 7.76e-04 3.68e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 25 4.85e-02 9.39e-02 0.2840 NA -0.268000 -0.094100 2.05e-02 4.15e-01
Myogenesis 21 8.08e-02 1.38e-01 0.2840 NA -0.203000 0.198000 1.07e-01 1.16e-01
Resolution of Abasic Sites (AP sites) 38 1.04e-02 2.85e-02 0.2830 NA 0.280000 -0.040900 2.78e-03 6.63e-01
RNA Polymerase III Abortive And Retractive Initiation 41 7.07e-03 2.12e-02 0.2830 NA -0.202000 -0.199000 2.54e-02 2.76e-02
RNA Polymerase III Transcription 41 7.07e-03 2.12e-02 0.2830 NA -0.202000 -0.199000 2.54e-02 2.76e-02
Mitochondrial calcium ion transport 22 7.02e-02 1.23e-01 0.2830 NA -0.114000 -0.259000 3.53e-01 3.54e-02
Vif-mediated degradation of APOBEC3G 49 2.73e-03 1.04e-02 0.2830 NA -0.221000 -0.176000 7.35e-03 3.28e-02
Inwardly rectifying K+ channels 13 2.10e-01 2.99e-01 0.2830 NA -0.005150 0.283000 9.74e-01 7.73e-02
Degradation of GLI2 by the proteasome 55 1.43e-03 5.95e-03 0.2820 NA -0.248000 -0.134000 1.49e-03 8.65e-02
GLI3 is processed to GLI3R by the proteasome 55 1.43e-03 5.95e-03 0.2820 NA -0.248000 -0.134000 1.49e-03 8.65e-02
Degradation of GLI1 by the proteasome 56 1.29e-03 5.45e-03 0.2810 NA -0.254000 -0.120000 9.91e-04 1.21e-01
Intra-Golgi traffic 40 9.01e-03 2.56e-02 0.2810 NA -0.268000 0.083200 3.33e-03 3.63e-01
Basigin interactions 23 6.84e-02 1.20e-01 0.2800 NA -0.203000 0.192000 9.17e-02 1.10e-01
TICAM1-dependent activation of IRF3/IRF7 11 2.76e-01 3.72e-01 0.2800 NA -0.267000 0.082800 1.25e-01 6.34e-01
IRS-mediated signalling 29 3.33e-02 7.01e-02 0.2800 NA -0.272000 -0.063300 1.12e-02 5.55e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 5.47e-02 1.03e-01 0.2780 NA -0.273000 -0.053800 1.81e-02 6.42e-01
Interactions of Vpr with host cellular proteins 36 1.52e-02 3.80e-02 0.2780 NA -0.075300 -0.268000 4.34e-01 5.42e-03
Degradation of beta-catenin by the destruction complex 81 8.36e-05 5.78e-04 0.2780 NA -0.250000 -0.122000 1.01e-04 5.84e-02
Interleukin-12 family signaling 45 5.39e-03 1.70e-02 0.2780 NA -0.239000 -0.143000 5.64e-03 9.81e-02
N-glycan antennae elongation in the medial/trans-Golgi 19 1.10e-01 1.77e-01 0.2780 NA -0.247000 -0.127000 6.23e-02 3.38e-01
TCR signaling 92 2.47e-05 2.10e-04 0.2780 NA -0.275000 -0.036200 5.03e-06 5.49e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 24 6.35e-02 1.14e-01 0.2780 NA -0.195000 0.198000 9.90e-02 9.30e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 57 1.36e-03 5.71e-03 0.2780 NA -0.201000 -0.191000 8.60e-03 1.26e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling 31 2.89e-02 6.24e-02 0.2770 NA -0.240000 0.139000 2.10e-02 1.81e-01
Association of TriC/CCT with target proteins during biosynthesis 38 1.25e-02 3.29e-02 0.2770 NA -0.133000 -0.243000 1.56e-01 9.57e-03
PI Metabolism 71 3.13e-04 1.77e-03 0.2760 NA -0.272000 0.049400 7.61e-05 4.72e-01
Glucagon-type ligand receptors 15 1.81e-01 2.63e-01 0.2750 NA 0.103000 0.255000 4.90e-01 8.68e-02
Sema4D induced cell migration and growth-cone collapse 20 1.05e-01 1.71e-01 0.2750 NA -0.127000 0.244000 3.27e-01 5.92e-02
Metabolism of water-soluble vitamins and cofactors 98 1.77e-05 1.56e-04 0.2740 NA 0.075400 -0.263000 1.97e-01 6.67e-06
mRNA decay by 3’ to 5’ exoribonuclease 16 1.67e-01 2.48e-01 0.2740 NA 0.069300 -0.265000 6.31e-01 6.67e-02
Signaling by the B Cell Receptor (BCR) 100 1.41e-05 1.30e-04 0.2740 NA -0.273000 0.014000 2.34e-06 8.08e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 4.33e-02 8.55e-02 0.2730 NA -0.247000 -0.117000 2.38e-02 2.86e-01
Host Interactions with Influenza Factors 42 9.03e-03 2.56e-02 0.2730 NA -0.166000 -0.217000 6.27e-02 1.51e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 13 2.33e-01 3.25e-01 0.2730 NA 0.254000 0.098500 1.12e-01 5.39e-01
alpha-linolenic acid (ALA) metabolism 13 2.33e-01 3.25e-01 0.2730 NA 0.254000 0.098500 1.12e-01 5.39e-01
Regulation of Apoptosis 50 3.73e-03 1.30e-02 0.2730 NA -0.223000 -0.158000 6.48e-03 5.41e-02
Regulation of ornithine decarboxylase (ODC) 48 4.67e-03 1.54e-02 0.2730 NA -0.230000 -0.147000 5.88e-03 7.86e-02
SUMOylation of DNA replication proteins 45 6.95e-03 2.11e-02 0.2720 NA 0.070300 -0.263000 4.15e-01 2.29e-03
SHC1 events in ERBB2 signaling 18 1.38e-01 2.13e-01 0.2720 NA -0.212000 0.170000 1.20e-01 2.11e-01
DNA Damage Recognition in GG-NER 38 1.49e-02 3.75e-02 0.2710 NA -0.090500 -0.256000 3.34e-01 6.34e-03
Negative regulation of NOTCH4 signaling 53 2.83e-03 1.05e-02 0.2710 NA -0.213000 -0.169000 7.47e-03 3.36e-02
Fcgamma receptor (FCGR) dependent phagocytosis 69 5.25e-04 2.67e-03 0.2710 NA -0.230000 0.144000 9.50e-04 3.92e-02
Purine catabolism 15 1.93e-01 2.78e-01 0.2710 NA 0.078600 -0.259000 5.98e-01 8.23e-02
Pausing and recovery of Tat-mediated HIV elongation 27 5.15e-02 9.86e-02 0.2710 NA -0.265000 -0.055200 1.72e-02 6.20e-01
Tat-mediated HIV elongation arrest and recovery 27 5.15e-02 9.86e-02 0.2710 NA -0.265000 -0.055200 1.72e-02 6.20e-01
EPHB-mediated forward signaling 34 2.46e-02 5.47e-02 0.2700 NA -0.226000 0.148000 2.25e-02 1.35e-01
NS1 Mediated Effects on Host Pathways 40 1.26e-02 3.30e-02 0.2700 NA -0.136000 -0.233000 1.36e-01 1.09e-02
Signaling by Erythropoietin 22 9.19e-02 1.53e-01 0.2700 NA -0.249000 0.104000 4.35e-02 3.98e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 2.42e-01 3.35e-01 0.2690 NA 0.247000 0.107000 1.23e-01 5.04e-01
FCERI mediated NF-kB activation 73 3.57e-04 1.97e-03 0.2690 NA -0.229000 -0.141000 7.18e-04 3.69e-02
Acyl chain remodelling of PG 11 3.02e-01 3.96e-01 0.2690 NA 0.253000 0.091000 1.46e-01 6.01e-01
RUNX2 regulates osteoblast differentiation 18 1.41e-01 2.17e-01 0.2690 NA 0.074800 0.258000 5.83e-01 5.77e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 21 1.04e-01 1.69e-01 0.2690 NA -0.103000 0.248000 4.16e-01 4.89e-02
Retrograde transport at the Trans-Golgi-Network 48 5.77e-03 1.79e-02 0.2680 NA -0.267000 -0.014400 1.35e-03 8.63e-01
Glucagon signaling in metabolic regulation 23 8.50e-02 1.44e-01 0.2670 NA 0.038900 0.264000 7.47e-01 2.82e-02
Transmission across Chemical Synapses 161 3.82e-08 5.90e-07 0.2670 NA -0.007450 0.267000 8.71e-01 5.12e-09
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 61 1.45e-03 5.99e-03 0.2670 NA -0.215000 -0.158000 3.70e-03 3.24e-02
Stabilization of p53 54 3.12e-03 1.13e-02 0.2670 NA -0.197000 -0.180000 1.23e-02 2.24e-02
Hyaluronan uptake and degradation 11 3.11e-01 4.07e-01 0.2660 NA -0.078600 0.255000 6.52e-01 1.44e-01
Nuclear Envelope Breakdown 52 4.09e-03 1.39e-02 0.2660 NA 0.024600 -0.265000 7.59e-01 9.54e-04
IGF1R signaling cascade 32 3.34e-02 7.01e-02 0.2660 NA -0.258000 -0.064300 1.15e-02 5.29e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 32 3.34e-02 7.01e-02 0.2660 NA -0.258000 -0.064300 1.15e-02 5.29e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 20 1.20e-01 1.90e-01 0.2660 NA -0.260000 -0.057200 4.44e-02 6.58e-01
Cellular response to hypoxia 70 6.04e-04 2.97e-03 0.2660 NA -0.210000 -0.163000 2.41e-03 1.86e-02
Import of palmitoyl-CoA into the mitochondrial matrix 11 3.15e-01 4.10e-01 0.2650 NA 0.188000 -0.188000 2.81e-01 2.81e-01
Neuronal System 223 8.12e-11 1.90e-09 0.2650 NA 0.002920 0.265000 9.40e-01 9.37e-12
Cargo recognition for clathrin-mediated endocytosis 82 1.96e-04 1.17e-03 0.2650 NA -0.186000 0.188000 3.53e-03 3.26e-03
Kinesins 38 1.84e-02 4.40e-02 0.2640 NA 0.165000 0.207000 7.92e-02 2.74e-02
TP53 Regulates Transcription of Death Receptors and Ligands 11 3.15e-01 4.10e-01 0.2640 NA -0.139000 -0.224000 4.23e-01 1.98e-01
Synthesis of bile acids and bile salts 28 5.33e-02 1.02e-01 0.2640 NA -0.164000 -0.207000 1.33e-01 5.86e-02
RHO GTPases activate CIT 19 1.38e-01 2.13e-01 0.2640 NA -0.027000 0.262000 8.39e-01 4.78e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 5.35e-02 1.02e-01 0.2640 NA -0.208000 -0.162000 5.69e-02 1.38e-01
Activation of G protein gated Potassium channels 11 3.18e-01 4.12e-01 0.2640 NA 0.005520 0.263000 9.75e-01 1.30e-01
G protein gated Potassium channels 11 3.18e-01 4.12e-01 0.2640 NA 0.005520 0.263000 9.75e-01 1.30e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 11 3.18e-01 4.12e-01 0.2640 NA 0.005520 0.263000 9.75e-01 1.30e-01
Vpu mediated degradation of CD4 49 6.07e-03 1.86e-02 0.2630 NA -0.212000 -0.157000 1.04e-02 5.80e-02
Signal transduction by L1 20 1.26e-01 1.98e-01 0.2630 NA -0.245000 0.095300 5.76e-02 4.61e-01
Processing and activation of SUMO 10 3.55e-01 4.51e-01 0.2630 NA -0.013600 -0.262000 9.41e-01 1.51e-01
Termination of O-glycan biosynthesis 14 2.40e-01 3.33e-01 0.2610 NA -0.237000 0.111000 1.25e-01 4.73e-01
Dopamine Neurotransmitter Release Cycle 17 1.76e-01 2.57e-01 0.2610 NA 0.027600 0.260000 8.44e-01 6.38e-02
PIP3 activates AKT signaling 225 1.45e-10 3.33e-09 0.2600 NA -0.244000 -0.090600 3.00e-10 1.94e-02
RAF activation 30 4.84e-02 9.38e-02 0.2600 NA -0.258000 0.026300 1.43e-02 8.03e-01
Lysine catabolism 12 2.98e-01 3.92e-01 0.2590 NA 0.258000 0.021500 1.21e-01 8.97e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 3.29e-01 4.24e-01 0.2590 NA -0.239000 -0.099600 1.70e-01 5.67e-01
Cilium Assembly 177 2.06e-08 3.36e-07 0.2590 NA 0.166000 0.199000 1.45e-04 5.20e-06
Activation of kainate receptors upon glutamate binding 17 1.83e-01 2.65e-01 0.2580 NA 0.022500 0.257000 8.73e-01 6.63e-02
Interleukin-1 signaling 93 9.24e-05 6.35e-04 0.2580 NA -0.238000 -0.101000 7.59e-05 9.16e-02
Signaling by MET 62 2.13e-03 8.46e-03 0.2580 NA -0.244000 0.082900 8.79e-04 2.59e-01
HDL remodeling 10 3.72e-01 4.68e-01 0.2570 NA 0.249000 -0.064200 1.73e-01 7.25e-01
Signaling by VEGF 90 1.41e-04 8.99e-04 0.2570 NA -0.253000 0.043200 3.26e-05 4.79e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 8.47e-02 1.44e-01 0.2560 NA 0.242000 0.083900 3.61e-02 4.68e-01
Early Phase of HIV Life Cycle 13 2.80e-01 3.75e-01 0.2560 NA 0.114000 -0.229000 4.75e-01 1.52e-01
Hyaluronan metabolism 13 2.80e-01 3.75e-01 0.2560 NA -0.084700 0.242000 5.97e-01 1.31e-01
PKMTs methylate histone lysines 37 2.64e-02 5.79e-02 0.2550 NA -0.182000 -0.179000 5.55e-02 5.92e-02
HDACs deacetylate histones 43 1.49e-02 3.75e-02 0.2550 NA -0.243000 -0.079100 5.91e-03 3.70e-01
Infectious disease 351 2.26e-15 7.94e-14 0.2550 NA -0.225000 -0.121000 5.26e-13 1.08e-04
PI3K/AKT Signaling in Cancer 69 1.25e-03 5.31e-03 0.2550 NA -0.249000 0.056700 3.58e-04 4.16e-01
Fc epsilon receptor (FCERI) signaling 115 1.51e-05 1.37e-04 0.2540 NA -0.254000 -0.006850 2.48e-06 8.99e-01
Keratinization 28 6.55e-02 1.17e-01 0.2540 NA -0.199000 -0.158000 6.79e-02 1.48e-01
IRAK2 mediated activation of TAK1 complex 10 3.78e-01 4.74e-01 0.2540 NA -0.138000 -0.214000 4.51e-01 2.42e-01
SUMOylation of chromatin organization proteins 56 4.53e-03 1.52e-02 0.2540 NA -0.009080 -0.254000 9.07e-01 1.03e-03
Biological oxidations 153 5.36e-07 7.45e-06 0.2530 NA 0.216000 -0.130000 3.96e-06 5.46e-03
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 13 2.88e-01 3.82e-01 0.2520 NA -0.075600 -0.241000 6.37e-01 1.33e-01
Synthesis of PIPs at the plasma membrane 44 1.52e-02 3.79e-02 0.2520 NA -0.251000 -0.024300 3.98e-03 7.80e-01
Vasopressin regulates renal water homeostasis via Aquaporins 27 7.75e-02 1.33e-01 0.2520 NA -0.023400 0.251000 8.33e-01 2.43e-02
IRS-related events triggered by IGF1R 31 5.27e-02 1.01e-01 0.2510 NA -0.235000 -0.089000 2.35e-02 3.91e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 2.41e-01 3.33e-01 0.2510 NA -0.099900 -0.231000 5.03e-01 1.22e-01
Synthesis of PA 25 9.46e-02 1.56e-01 0.2510 NA 0.247000 0.040600 3.23e-02 7.25e-01
Complex I biogenesis 55 5.69e-03 1.77e-02 0.2510 NA -0.029900 -0.249000 7.01e-01 1.42e-03
TICAM1,TRAF6-dependent induction of TAK1 complex 10 3.90e-01 4.86e-01 0.2500 NA -0.073500 -0.239000 6.87e-01 1.90e-01
Transcriptional activation of mitochondrial biogenesis 50 9.09e-03 2.56e-02 0.2500 NA -0.113000 -0.223000 1.69e-01 6.29e-03
Endogenous sterols 19 1.71e-01 2.53e-01 0.2500 NA 0.158000 -0.194000 2.34e-01 1.44e-01
Signal amplification 18 1.88e-01 2.71e-01 0.2500 NA -0.182000 0.171000 1.81e-01 2.10e-01
Ion channel transport 116 2.26e-05 1.93e-04 0.2490 NA -0.168000 0.184000 1.78e-03 6.10e-04
mRNA Splicing - Minor Pathway 51 8.53e-03 2.48e-02 0.2490 NA -0.129000 -0.213000 1.10e-01 8.48e-03
HIV elongation arrest and recovery 29 6.68e-02 1.18e-01 0.2490 NA -0.239000 -0.071200 2.60e-02 5.07e-01
Pausing and recovery of HIV elongation 29 6.68e-02 1.18e-01 0.2490 NA -0.239000 -0.071200 2.60e-02 5.07e-01
Repression of WNT target genes 14 2.73e-01 3.70e-01 0.2490 NA -0.235000 0.082400 1.28e-01 5.94e-01
Ovarian tumor domain proteases 35 3.90e-02 7.91e-02 0.2490 NA -0.245000 -0.043700 1.22e-02 6.54e-01
Mitochondrial biogenesis 71 1.41e-03 5.89e-03 0.2480 NA -0.134000 -0.209000 5.14e-02 2.33e-03
Regulation of RAS by GAPs 63 2.98e-03 1.09e-02 0.2480 NA -0.225000 -0.104000 2.02e-03 1.52e-01
Transcriptional regulation by RUNX3 94 1.73e-04 1.07e-03 0.2480 NA -0.190000 -0.160000 1.50e-03 7.49e-03
Chromosome Maintenance 76 9.38e-04 4.19e-03 0.2480 NA 0.241000 0.056300 2.81e-04 3.97e-01
Lewis blood group biosynthesis 11 3.64e-01 4.59e-01 0.2470 NA -0.047400 -0.243000 7.86e-01 1.63e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 86 3.94e-04 2.09e-03 0.2470 NA -0.245000 0.032900 8.59e-05 5.99e-01
Toll Like Receptor 2 (TLR2) Cascade 86 3.94e-04 2.09e-03 0.2470 NA -0.245000 0.032900 8.59e-05 5.99e-01
Toll Like Receptor TLR1:TLR2 Cascade 86 3.94e-04 2.09e-03 0.2470 NA -0.245000 0.032900 8.59e-05 5.99e-01
Toll Like Receptor TLR6:TLR2 Cascade 86 3.94e-04 2.09e-03 0.2470 NA -0.245000 0.032900 8.59e-05 5.99e-01
Aquaporin-mediated transport 31 5.90e-02 1.09e-01 0.2470 NA -0.028000 0.246000 7.88e-01 1.80e-02
Constitutive Signaling by Aberrant PI3K in Cancer 42 2.21e-02 5.11e-02 0.2470 NA -0.211000 0.128000 1.79e-02 1.51e-01
SUMOylation of DNA damage response and repair proteins 75 1.11e-03 4.83e-03 0.2460 NA 0.005230 -0.246000 9.38e-01 2.26e-04
Integrin cell surface interactions 42 2.20e-02 5.10e-02 0.2460 NA 0.220000 0.110000 1.38e-02 2.16e-01
Organic cation/anion/zwitterion transport 10 4.04e-01 4.95e-01 0.2460 NA -0.241000 -0.049000 1.87e-01 7.88e-01
Formation of TC-NER Pre-Incision Complex 53 8.25e-03 2.41e-02 0.2450 NA -0.182000 -0.165000 2.20e-02 3.82e-02
Regulation of PTEN gene transcription 59 5.07e-03 1.64e-02 0.2440 NA -0.222000 -0.103000 3.23e-03 1.73e-01
Cross-presentation of soluble exogenous antigens (endosomes) 44 1.93e-02 4.55e-02 0.2440 NA -0.203000 -0.136000 2.00e-02 1.18e-01
Costimulation by the CD28 family 45 1.87e-02 4.44e-02 0.2440 NA -0.219000 0.106000 1.09e-02 2.19e-01
MicroRNA (miRNA) biogenesis 24 1.17e-01 1.87e-01 0.2430 NA -0.174000 -0.171000 1.41e-01 1.48e-01
Bile acid and bile salt metabolism 31 6.34e-02 1.14e-01 0.2430 NA -0.125000 -0.209000 2.28e-01 4.45e-02
TP53 Regulates Transcription of Caspase Activators and Caspases 10 4.14e-01 5.05e-01 0.2430 NA 0.241000 -0.030200 1.87e-01 8.69e-01
MET activates PTK2 signaling 15 2.67e-01 3.64e-01 0.2430 NA -0.236000 0.055200 1.13e-01 7.12e-01
Integration of energy metabolism 81 8.33e-04 3.82e-03 0.2420 NA -0.037700 0.239000 5.57e-01 1.97e-04
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 13 3.17e-01 4.12e-01 0.2420 NA 0.139000 0.199000 3.86e-01 2.15e-01
Clathrin-mediated endocytosis 117 3.82e-05 2.98e-04 0.2420 NA -0.187000 0.154000 4.83e-04 4.03e-03
Neurexins and neuroligins 39 3.23e-02 6.87e-02 0.2420 NA 0.073200 0.231000 4.29e-01 1.26e-02
MET promotes cell motility 26 1.03e-01 1.67e-01 0.2420 NA -0.238000 0.044800 3.59e-02 6.92e-01
Fatty acyl-CoA biosynthesis 30 7.17e-02 1.25e-01 0.2420 NA 0.205000 0.127000 5.15e-02 2.28e-01
Insulin processing 20 1.76e-01 2.57e-01 0.2410 NA -0.174000 0.167000 1.77e-01 1.96e-01
Fanconi Anemia Pathway 34 5.11e-02 9.83e-02 0.2410 NA 0.214000 0.112000 3.11e-02 2.59e-01
Anchoring of the basal body to the plasma membrane 94 2.77e-04 1.60e-03 0.2410 NA 0.185000 0.155000 1.97e-03 9.59e-03
GPCR ligand binding 136 7.93e-06 8.36e-05 0.2410 NA 0.027900 0.239000 5.75e-01 1.50e-06
Heparan sulfate/heparin (HS-GAG) metabolism 43 2.37e-02 5.36e-02 0.2410 NA 0.105000 0.216000 2.32e-01 1.41e-02
tRNA processing 135 8.88e-06 9.05e-05 0.2410 NA 0.005900 -0.241000 9.06e-01 1.42e-06
VEGFA-VEGFR2 Pathway 86 6.46e-04 3.10e-03 0.2390 NA -0.236000 0.040800 1.57e-04 5.14e-01
Regulation of FZD by ubiquitination 15 2.74e-01 3.71e-01 0.2390 NA -0.106000 -0.215000 4.77e-01 1.50e-01
Negative regulation of the PI3K/AKT network 74 1.82e-03 7.32e-03 0.2390 NA -0.234000 0.050300 5.07e-04 4.54e-01
The phototransduction cascade 21 1.67e-01 2.48e-01 0.2390 NA -0.074600 0.227000 5.54e-01 7.19e-02
G1/S-Specific Transcription 28 9.07e-02 1.51e-01 0.2390 NA 0.195000 0.138000 7.41e-02 2.08e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 54 1.04e-02 2.85e-02 0.2380 NA 0.089400 -0.221000 2.56e-01 5.03e-03
Regulation of RUNX2 expression and activity 66 3.70e-03 1.29e-02 0.2380 NA -0.232000 -0.051100 1.10e-03 4.73e-01
CLEC7A (Dectin-1) signaling 91 4.47e-04 2.34e-03 0.2380 NA -0.223000 -0.082700 2.37e-04 1.73e-01
Chylomicron assembly 10 4.30e-01 5.20e-01 0.2370 NA 0.030500 -0.235000 8.67e-01 1.97e-01
SUMOylation of DNA methylation proteins 16 2.61e-01 3.57e-01 0.2370 NA 0.077400 -0.224000 5.92e-01 1.21e-01
RA biosynthesis pathway 15 2.85e-01 3.80e-01 0.2370 NA 0.151000 -0.182000 3.10e-01 2.21e-01
Cell-Cell communication 84 9.14e-04 4.10e-03 0.2370 NA -0.093900 0.217000 1.37e-01 5.81e-04
Synthesis of PIPs at the late endosome membrane 11 4.01e-01 4.94e-01 0.2360 NA -0.218000 0.090200 2.11e-01 6.05e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 49 1.68e-02 4.09e-02 0.2360 NA -0.183000 -0.148000 2.64e-02 7.35e-02
p53-Independent DNA Damage Response 49 1.68e-02 4.09e-02 0.2360 NA -0.183000 -0.148000 2.64e-02 7.35e-02
p53-Independent G1/S DNA damage checkpoint 49 1.68e-02 4.09e-02 0.2360 NA -0.183000 -0.148000 2.64e-02 7.35e-02
SUMOylation 164 1.35e-06 1.73e-05 0.2350 NA -0.095600 -0.215000 3.48e-02 2.15e-06
Ub-specific processing proteases 162 1.60e-06 1.98e-05 0.2350 NA -0.169000 -0.163000 2.03e-04 3.59e-04
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 67 4.09e-03 1.39e-02 0.2350 NA -0.218000 0.087300 2.04e-03 2.17e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 1.06e-01 1.72e-01 0.2350 NA -0.186000 -0.144000 9.50e-02 1.96e-01
Homology Directed Repair 107 1.51e-04 9.47e-04 0.2350 NA 0.233000 0.026000 3.08e-05 6.42e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 2.85e-02 6.18e-02 0.2350 NA -0.194000 -0.132000 2.81e-02 1.33e-01
Autodegradation of Cdh1 by Cdh1:APC/C 62 6.03e-03 1.85e-02 0.2340 NA -0.108000 -0.208000 1.42e-01 4.62e-03
Inositol phosphate metabolism 40 3.81e-02 7.78e-02 0.2340 NA -0.169000 0.163000 6.52e-02 7.50e-02
SUMO E3 ligases SUMOylate target proteins 158 2.44e-06 2.89e-05 0.2340 NA -0.092300 -0.215000 4.56e-02 3.11e-06
MET activates RAP1 and RAC1 10 4.40e-01 5.29e-01 0.2340 NA -0.232000 0.030700 2.04e-01 8.66e-01
Cell-cell junction organization 35 5.59e-02 1.05e-01 0.2340 NA 0.111000 0.206000 2.58e-01 3.47e-02
PIWI-interacting RNA (piRNA) biogenesis 21 1.83e-01 2.65e-01 0.2330 NA -0.114000 0.203000 3.65e-01 1.07e-01
HS-GAG biosynthesis 23 1.54e-01 2.33e-01 0.2320 NA 0.153000 0.175000 2.04e-01 1.47e-01
Axon guidance 443 8.09e-16 3.20e-14 0.2320 NA -0.218000 0.080300 4.70e-15 3.90e-03
Gap junction trafficking and regulation 17 2.54e-01 3.49e-01 0.2320 NA 0.038600 0.229000 7.83e-01 1.03e-01
Regulation of gene expression by Hypoxia-inducible Factor 11 4.13e-01 5.04e-01 0.2310 NA -0.226000 -0.047500 1.93e-01 7.85e-01
Interleukin-1 family signaling 111 1.40e-04 8.99e-04 0.2310 NA -0.204000 -0.109000 2.11e-04 4.75e-02
Cellular response to heat stress 94 5.39e-04 2.73e-03 0.2310 NA -0.168000 -0.159000 4.95e-03 7.83e-03
Synthesis of PIPs at the Golgi membrane 15 3.04e-01 3.98e-01 0.2310 NA -0.176000 0.149000 2.38e-01 3.18e-01
Metabolism of cofactors 18 2.43e-01 3.35e-01 0.2300 NA 0.064800 -0.220000 6.34e-01 1.06e-01
Purine salvage 12 3.87e-01 4.82e-01 0.2300 NA 0.072100 0.218000 6.66e-01 1.91e-01
Other interleukin signaling 18 2.45e-01 3.38e-01 0.2290 NA -0.027800 0.227000 8.38e-01 9.58e-02
Cytosolic sensors of pathogen-associated DNA 57 1.16e-02 3.08e-02 0.2280 NA -0.198000 -0.114000 9.87e-03 1.36e-01
Signaling by NOTCH3 44 3.35e-02 7.02e-02 0.2280 NA -0.126000 0.190000 1.49e-01 2.95e-02
Signaling by TGF-beta family members 89 1.01e-03 4.46e-03 0.2280 NA -0.224000 -0.041900 2.66e-04 4.94e-01
ABC-family proteins mediated transport 92 8.04e-04 3.74e-03 0.2280 NA -0.224000 -0.041600 2.09e-04 4.91e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 1.33e-01 2.06e-01 0.2270 NA 0.013800 0.227000 9.03e-01 4.51e-02
Regulated proteolysis of p75NTR 11 4.26e-01 5.17e-01 0.2270 NA -0.198000 -0.110000 2.55e-01 5.28e-01
Processing of Capped Intronless Pre-mRNA 28 1.16e-01 1.84e-01 0.2270 NA -0.035000 -0.224000 7.49e-01 4.03e-02
Cellular hexose transport 16 2.93e-01 3.87e-01 0.2270 NA -0.067800 0.216000 6.39e-01 1.34e-01
Signaling by GPCR 384 2.94e-13 9.30e-12 0.2270 NA -0.051800 0.221000 8.25e-02 1.32e-13
Mucopolysaccharidoses 11 4.28e-01 5.18e-01 0.2260 NA -0.197000 -0.111000 2.57e-01 5.25e-01
tRNA processing in the nucleus 57 1.29e-02 3.37e-02 0.2260 NA -0.073100 -0.213000 3.40e-01 5.33e-03
PCNA-Dependent Long Patch Base Excision Repair 21 2.01e-01 2.87e-01 0.2250 NA 0.198000 0.108000 1.16e-01 3.93e-01
Nonhomologous End-Joining (NHEJ) 42 4.16e-02 8.31e-02 0.2250 NA 0.046300 -0.220000 6.04e-01 1.35e-02
Keratan sulfate/keratin metabolism 23 1.77e-01 2.59e-01 0.2250 NA -0.172000 0.145000 1.54e-01 2.28e-01
Interleukin-10 signaling 18 2.56e-01 3.51e-01 0.2240 NA 0.139000 0.176000 3.08e-01 1.95e-01
Signaling by ERBB4 36 6.73e-02 1.19e-01 0.2240 NA -0.218000 -0.047500 2.33e-02 6.22e-01
Intracellular signaling by second messengers 255 6.67e-09 1.16e-07 0.2230 NA -0.221000 -0.029500 1.22e-09 4.18e-01
Sulfur amino acid metabolism 25 1.56e-01 2.35e-01 0.2230 NA 0.219000 -0.040900 5.79e-02 7.23e-01
AURKA Activation by TPX2 71 5.06e-03 1.64e-02 0.2230 NA 0.211000 0.070700 2.08e-03 3.03e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 3.79e-01 4.75e-01 0.2230 NA -0.115000 -0.190000 4.71e-01 2.35e-01
RHO GTPases Activate WASPs and WAVEs 33 8.75e-02 1.48e-01 0.2220 NA -0.206000 0.084200 4.07e-02 4.03e-01
Deubiquitination 234 3.70e-08 5.78e-07 0.2220 NA -0.164000 -0.149000 1.53e-05 9.06e-05
Hedgehog ‘on’ state 75 4.03e-03 1.39e-02 0.2220 NA -0.217000 -0.042900 1.13e-03 5.21e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 101 6.07e-04 2.97e-03 0.2220 NA 0.221000 0.020800 1.28e-04 7.19e-01
APC/C:Cdc20 mediated degradation of Securin 64 8.99e-03 2.56e-02 0.2210 NA -0.094400 -0.200000 1.92e-01 5.58e-03
Diseases of metabolism 77 3.67e-03 1.29e-02 0.2210 NA 0.029800 -0.219000 6.51e-01 8.97e-04
TICAM1, RIP1-mediated IKK complex recruitment 18 2.68e-01 3.65e-01 0.2210 NA -0.217000 -0.039300 1.11e-01 7.73e-01
Pre-NOTCH Processing in Golgi 18 2.71e-01 3.67e-01 0.2210 NA -0.096100 0.199000 4.80e-01 1.45e-01
Protein localization 150 1.92e-05 1.66e-04 0.2210 NA -0.028400 -0.219000 5.49e-01 3.86e-06
TNFR1-induced NFkappaB signaling pathway 24 1.75e-01 2.56e-01 0.2200 NA -0.040600 -0.216000 7.31e-01 6.67e-02
Signaling by SCF-KIT 37 7.11e-02 1.24e-01 0.2190 NA -0.104000 0.193000 2.73e-01 4.27e-02
NOTCH3 Intracellular Domain Regulates Transcription 21 2.24e-01 3.15e-01 0.2180 NA -0.006090 0.218000 9.61e-01 8.35e-02
HSF1-dependent transactivation 33 9.54e-02 1.56e-01 0.2180 NA -0.203000 -0.077600 4.32e-02 4.41e-01
Regulation of HSF1-mediated heat shock response 76 4.58e-03 1.53e-02 0.2170 NA -0.164000 -0.143000 1.37e-02 3.12e-02
Loss of Nlp from mitotic centrosomes 68 8.14e-03 2.39e-02 0.2170 NA 0.198000 0.088300 4.68e-03 2.08e-01
Loss of proteins required for interphase microtubule organization from the centrosome 68 8.14e-03 2.39e-02 0.2170 NA 0.198000 0.088300 4.68e-03 2.08e-01
RNA Polymerase I Transcription Initiation 47 3.62e-02 7.46e-02 0.2170 NA -0.022500 -0.216000 7.90e-01 1.04e-02
Regulation of TP53 Degradation 35 8.35e-02 1.42e-01 0.2170 NA -0.143000 -0.163000 1.43e-01 9.49e-02
Regulation of TP53 Expression and Degradation 35 8.35e-02 1.42e-01 0.2170 NA -0.143000 -0.163000 1.43e-01 9.49e-02
Regulation of IFNA signaling 12 4.29e-01 5.19e-01 0.2170 NA 0.211000 0.049400 2.06e-01 7.67e-01
SCF(Skp2)-mediated degradation of p27/p21 57 1.82e-02 4.36e-02 0.2160 NA -0.183000 -0.115000 1.68e-02 1.33e-01
TP53 Regulates Transcription of Cell Death Genes 40 6.00e-02 1.11e-01 0.2160 NA -0.132000 -0.172000 1.50e-01 6.06e-02
GPCR downstream signalling 353 3.69e-11 9.33e-10 0.2150 NA -0.056300 0.208000 6.98e-02 2.09e-11
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 1.42e-01 2.18e-01 0.2150 NA -0.212000 -0.038600 5.23e-02 7.24e-01
RAF/MAP kinase cascade 194 1.70e-06 2.09e-05 0.2150 NA -0.185000 0.110000 9.04e-06 8.25e-03
Budding and maturation of HIV virion 28 1.42e-01 2.18e-01 0.2150 NA -0.142000 -0.162000 1.94e-01 1.38e-01
Signaling by Activin 11 4.66e-01 5.56e-01 0.2150 NA -0.215000 0.006250 2.17e-01 9.71e-01
G beta:gamma signalling through PLC beta 11 4.69e-01 5.57e-01 0.2150 NA -0.144000 0.159000 4.07e-01 3.61e-01
Presynaptic function of Kainate receptors 11 4.69e-01 5.57e-01 0.2150 NA -0.144000 0.159000 4.07e-01 3.61e-01
Regulation of APC/C activators between G1/S and early anaphase 76 5.27e-03 1.68e-02 0.2150 NA -0.041700 -0.211000 5.30e-01 1.50e-03
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 68 9.22e-03 2.57e-02 0.2150 NA -0.045600 -0.210000 5.16e-01 2.81e-03
Assembly of active LPL and LIPC lipase complexes 15 3.57e-01 4.53e-01 0.2140 NA 0.193000 -0.094000 1.96e-01 5.28e-01
Phase I - Functionalization of compounds 72 7.49e-03 2.23e-02 0.2140 NA 0.172000 -0.127000 1.18e-02 6.16e-02
C-type lectin receptors (CLRs) 117 3.50e-04 1.94e-03 0.2140 NA -0.214000 -0.005260 6.68e-05 9.22e-01
TP53 Regulates Metabolic Genes 84 3.20e-03 1.15e-02 0.2140 NA -0.188000 -0.101000 2.90e-03 1.09e-01
Cell junction organization 55 2.40e-02 5.39e-02 0.2130 NA -0.084600 0.196000 2.78e-01 1.20e-02
Signaling by Receptor Tyrosine Kinases 357 4.97e-11 1.21e-09 0.2130 NA -0.201000 0.069200 6.77e-11 2.52e-02
Interferon gamma signaling 65 1.19e-02 3.16e-02 0.2130 NA 0.124000 0.173000 8.46e-02 1.57e-02
Host Interactions of HIV factors 120 2.93e-04 1.68e-03 0.2130 NA -0.168000 -0.131000 1.51e-03 1.34e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 23 2.14e-01 3.03e-01 0.2120 NA -0.211000 0.019000 8.02e-02 8.75e-01
Signaling by FGFR 68 1.07e-02 2.91e-02 0.2120 NA -0.210000 0.022200 2.72e-03 7.52e-01
Metabolism of porphyrins 14 3.92e-01 4.87e-01 0.2110 NA 0.005700 0.211000 9.71e-01 1.71e-01
Glycogen synthesis 14 3.92e-01 4.87e-01 0.2110 NA -0.101000 -0.185000 5.15e-01 2.30e-01
Disorders of transmembrane transporters 136 1.18e-04 7.70e-04 0.2110 NA -0.154000 -0.144000 1.97e-03 3.73e-03
Collagen biosynthesis and modifying enzymes 34 1.04e-01 1.69e-01 0.2110 NA 0.207000 0.039500 3.69e-02 6.91e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 14 3.94e-01 4.89e-01 0.2100 NA -0.089700 -0.190000 5.61e-01 2.18e-01
Activation of NMDA receptors and postsynaptic events 61 1.80e-02 4.32e-02 0.2100 NA 0.034700 0.207000 6.39e-01 5.21e-03
Mitochondrial iron-sulfur cluster biogenesis 12 4.54e-01 5.44e-01 0.2090 NA 0.206000 0.035100 2.16e-01 8.33e-01
MAPK6/MAPK4 signaling 84 4.08e-03 1.39e-02 0.2090 NA -0.206000 -0.036800 1.11e-03 5.60e-01
p53-Dependent G1 DNA Damage Response 62 1.70e-02 4.11e-02 0.2090 NA -0.175000 -0.115000 1.74e-02 1.17e-01
p53-Dependent G1/S DNA damage checkpoint 62 1.70e-02 4.11e-02 0.2090 NA -0.175000 -0.115000 1.74e-02 1.17e-01
Toll Like Receptor 4 (TLR4) Cascade 110 8.13e-04 3.75e-03 0.2090 NA -0.202000 0.051100 2.50e-04 3.55e-01
FGFR2 mutant receptor activation 20 2.72e-01 3.69e-01 0.2090 NA -0.029100 0.207000 8.22e-01 1.10e-01
Deposition of new CENPA-containing nucleosomes at the centromere 41 6.93e-02 1.22e-01 0.2080 NA 0.205000 0.038500 2.33e-02 6.69e-01
Nucleosome assembly 41 6.93e-02 1.22e-01 0.2080 NA 0.205000 0.038500 2.33e-02 6.69e-01
MAPK family signaling cascades 236 2.84e-07 4.04e-06 0.2080 NA -0.178000 0.108000 2.59e-06 4.23e-03
CDT1 association with the CDC6:ORC:origin complex 56 2.63e-02 5.79e-02 0.2080 NA -0.187000 -0.090700 1.54e-02 2.40e-01
Metabolism of amino acids and derivatives 315 1.77e-09 3.45e-08 0.2080 NA -0.090400 -0.187000 5.90e-03 1.17e-08
TCF dependent signaling in response to WNT 163 2.72e-05 2.25e-04 0.2080 NA -0.179000 -0.106000 8.12e-05 2.02e-02
FOXO-mediated transcription 56 2.71e-02 5.93e-02 0.2080 NA -0.207000 0.009770 7.28e-03 8.99e-01
Fatty acid metabolism 134 1.93e-04 1.16e-03 0.2070 NA 0.207000 -0.006470 3.56e-05 8.97e-01
Post-translational protein phosphorylation 88 3.55e-03 1.26e-02 0.2070 NA -0.061100 -0.198000 3.22e-01 1.35e-03
RNA Polymerase III Transcription Initiation 36 9.87e-02 1.61e-01 0.2070 NA -0.155000 -0.137000 1.07e-01 1.56e-01
GABA synthesis, release, reuptake and degradation 13 4.37e-01 5.27e-01 0.2070 NA -0.141000 0.151000 3.77e-01 3.47e-01
Syndecan interactions 18 3.18e-01 4.12e-01 0.2070 NA -0.166000 0.123000 2.24e-01 3.64e-01
Thromboxane signalling through TP receptor 13 4.38e-01 5.28e-01 0.2060 NA -0.175000 0.109000 2.75e-01 4.95e-01
Interleukin-37 signaling 16 3.62e-01 4.57e-01 0.2060 NA -0.031000 -0.203000 8.30e-01 1.59e-01
MAPK1/MAPK3 signaling 199 4.22e-06 4.81e-05 0.2050 NA -0.176000 0.106000 1.97e-05 9.94e-03
Telomere Maintenance 50 4.28e-02 8.48e-02 0.2050 NA 0.188000 0.080700 2.13e-02 3.24e-01
Sphingolipid de novo biosynthesis 38 9.33e-02 1.55e-01 0.2050 NA -0.175000 0.106000 6.17e-02 2.59e-01
Respiratory electron transport 101 1.81e-03 7.31e-03 0.2040 NA -0.058800 -0.196000 3.08e-01 6.77e-04
Prolactin receptor signaling 11 5.02e-01 5.91e-01 0.2040 NA -0.040300 -0.200000 8.17e-01 2.50e-01
Class A/1 (Rhodopsin-like receptors) 83 5.83e-03 1.80e-02 0.2040 NA -0.003900 0.204000 9.51e-01 1.34e-03
Plasma lipoprotein clearance 31 1.46e-01 2.22e-01 0.2040 NA -0.203000 0.013300 5.01e-02 8.98e-01
Signaling by ERBB2 44 6.66e-02 1.18e-01 0.2030 NA -0.193000 0.062200 2.65e-02 4.75e-01
Interleukin-7 signaling 17 3.53e-01 4.49e-01 0.2030 NA 0.144000 -0.143000 3.06e-01 3.07e-01
Signaling by NOTCH1 68 1.56e-02 3.87e-02 0.2030 NA -0.190000 0.071500 6.86e-03 3.08e-01
G-protein beta:gamma signalling 18 3.31e-01 4.26e-01 0.2030 NA -0.192000 0.065000 1.59e-01 6.33e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 72 1.21e-02 3.20e-02 0.2020 NA -0.016500 -0.202000 8.09e-01 3.08e-03
Synthesis of substrates in N-glycan biosythesis 52 4.19e-02 8.35e-02 0.2020 NA -0.185000 0.081900 2.10e-02 3.07e-01
RHO GTPases activate IQGAPs 11 5.14e-01 6.02e-01 0.2010 NA -0.101000 0.174000 5.61e-01 3.18e-01
Positive epigenetic regulation of rRNA expression 61 2.46e-02 5.47e-02 0.2010 NA -0.122000 -0.160000 9.95e-02 3.09e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 69 1.56e-02 3.87e-02 0.2010 NA -0.035700 -0.198000 6.08e-01 4.56e-03
Transcriptional regulation by RUNX1 170 3.63e-05 2.91e-04 0.2010 NA -0.129000 -0.154000 3.85e-03 5.39e-04
ECM proteoglycans 35 1.21e-01 1.91e-01 0.2010 NA 0.054000 0.193000 5.80e-01 4.79e-02
FGFR2 alternative splicing 26 2.10e-01 2.99e-01 0.2000 NA -0.149000 -0.133000 1.87e-01 2.42e-01
Signaling by FGFR2 in disease 30 1.69e-01 2.51e-01 0.1990 NA -0.114000 0.163000 2.79e-01 1.21e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) 34 1.33e-01 2.06e-01 0.1990 NA -0.198000 0.021000 4.57e-02 8.32e-01
Rho GTPase cycle 118 9.65e-04 4.30e-03 0.1990 NA -0.073000 0.185000 1.71e-01 5.14e-04
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 69 1.66e-02 4.08e-02 0.1990 NA -0.054300 -0.192000 4.36e-01 5.95e-03
Estrogen-dependent gene expression 98 2.97e-03 1.09e-02 0.1990 NA -0.154000 -0.126000 8.36e-03 3.16e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs 77 1.04e-02 2.85e-02 0.1990 NA -0.175000 -0.093600 7.81e-03 1.56e-01
Transcriptional regulation of white adipocyte differentiation 76 1.18e-02 3.12e-02 0.1970 NA -0.148000 -0.130000 2.55e-02 4.99e-02
Membrane Trafficking 543 5.55e-14 1.85e-12 0.1970 NA -0.178000 0.083700 1.36e-12 8.97e-04
Formation of Incision Complex in GG-NER 43 8.35e-02 1.42e-01 0.1970 NA 0.137000 -0.142000 1.21e-01 1.08e-01
Dissolution of Fibrin Clot 12 4.99e-01 5.89e-01 0.1970 NA 0.196000 -0.006050 2.39e-01 9.71e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 173 5.33e-05 3.90e-04 0.1960 NA -0.187000 0.058500 2.23e-05 1.85e-01
Cyclin E associated events during G1/S transition 80 1.00e-02 2.76e-02 0.1960 NA -0.150000 -0.126000 2.06e-02 5.13e-02
Post NMDA receptor activation events 51 5.49e-02 1.04e-01 0.1950 NA 0.011700 0.195000 8.85e-01 1.62e-02
Signaling by FGFR2 58 3.72e-02 7.62e-02 0.1950 NA -0.194000 0.021500 1.07e-02 7.77e-01
VEGFR2 mediated cell proliferation 18 3.61e-01 4.57e-01 0.1950 NA -0.170000 0.095400 2.12e-01 4.83e-01
ESR-mediated signaling 152 1.86e-04 1.13e-03 0.1950 NA -0.188000 -0.052400 6.72e-05 2.66e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 31 1.73e-01 2.54e-01 0.1940 NA -0.087500 -0.173000 3.99e-01 9.52e-02
PECAM1 interactions 10 5.69e-01 6.53e-01 0.1940 NA -0.015900 0.193000 9.31e-01 2.90e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 71 1.86e-02 4.42e-02 0.1940 NA -0.025100 -0.192000 7.14e-01 5.14e-03
PCP/CE pathway 83 9.63e-03 2.67e-02 0.1940 NA -0.193000 0.010700 2.34e-03 8.66e-01
Cytosolic sulfonation of small molecules 20 3.25e-01 4.20e-01 0.1940 NA 0.193000 0.012800 1.35e-01 9.21e-01
Metabolic disorders of biological oxidation enzymes 24 2.65e-01 3.62e-01 0.1930 NA 0.143000 -0.130000 2.26e-01 2.72e-01
BBSome-mediated cargo-targeting to cilium 23 2.79e-01 3.74e-01 0.1930 NA -0.013500 0.192000 9.11e-01 1.11e-01
Base Excision Repair 59 3.82e-02 7.78e-02 0.1920 NA 0.192000 -0.011400 1.07e-02 8.79e-01
Triglyceride catabolism 12 5.17e-01 6.05e-01 0.1920 NA -0.143000 0.128000 3.91e-01 4.42e-01
Recruitment of NuMA to mitotic centrosomes 79 1.30e-02 3.39e-02 0.1920 NA 0.187000 0.040000 3.98e-03 5.39e-01
Signaling by Interleukins 314 4.06e-08 6.19e-07 0.1920 NA -0.188000 -0.035700 1.02e-08 2.78e-01
Sphingolipid metabolism 75 1.68e-02 4.09e-02 0.1910 NA -0.176000 0.075100 8.45e-03 2.61e-01
Glycosaminoglycan metabolism 96 5.38e-03 1.70e-02 0.1910 NA -0.023900 0.190000 6.86e-01 1.33e-03
Metabolism of proteins 1653 2.13e-36 8.99e-34 0.1910 NA -0.160000 -0.104000 7.67e-27 4.09e-12
rRNA processing in the mitochondrion 32 1.75e-01 2.57e-01 0.1910 NA 0.013800 -0.190000 8.93e-01 6.26e-02
Developmental Biology 686 2.92e-16 1.28e-14 0.1910 NA -0.184000 0.049500 2.87e-16 2.81e-02
DNA Double-Strand Break Repair 132 8.13e-04 3.75e-03 0.1900 NA 0.189000 -0.023200 1.79e-04 6.46e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 96 5.57e-03 1.74e-02 0.1900 NA -0.022400 -0.189000 7.05e-01 1.39e-03
RHO GTPases Activate NADPH Oxidases 16 4.23e-01 5.14e-01 0.1900 NA -0.103000 0.160000 4.75e-01 2.69e-01
Platelet sensitization by LDL 14 4.71e-01 5.59e-01 0.1900 NA -0.152000 0.113000 3.23e-01 4.62e-01
p75 NTR receptor-mediated signalling 83 1.15e-02 3.07e-02 0.1900 NA -0.188000 0.025100 3.03e-03 6.93e-01
Cellular responses to external stimuli 424 1.79e-10 3.97e-09 0.1900 NA -0.166000 -0.092000 5.02e-09 1.20e-03
Tight junction interactions 20 3.39e-01 4.35e-01 0.1900 NA 0.022500 0.188000 8.62e-01 1.45e-01
Metabolism of polyamines 77 1.57e-02 3.89e-02 0.1900 NA -0.157000 -0.106000 1.72e-02 1.08e-01
Neurotransmitter release cycle 35 1.55e-01 2.34e-01 0.1890 NA -0.116000 0.149000 2.36e-01 1.26e-01
Interferon alpha/beta signaling 52 6.14e-02 1.12e-01 0.1890 NA 0.127000 0.140000 1.13e-01 8.09e-02
Vesicle-mediated transport 568 2.10e-13 6.82e-12 0.1890 NA -0.173000 0.075200 2.21e-12 2.29e-03
TNFR2 non-canonical NF-kB pathway 76 1.74e-02 4.21e-02 0.1890 NA -0.173000 -0.074700 9.11e-03 2.61e-01
Rab regulation of trafficking 115 2.38e-03 9.26e-03 0.1880 NA -0.163000 0.094900 2.62e-03 7.90e-02
Formation of RNA Pol II elongation complex 54 5.70e-02 1.07e-01 0.1880 NA -0.177000 -0.064700 2.49e-02 4.11e-01
RNA Polymerase II Transcription Elongation 54 5.70e-02 1.07e-01 0.1880 NA -0.177000 -0.064700 2.49e-02 4.11e-01
Binding and Uptake of Ligands by Scavenger Receptors 28 2.25e-01 3.18e-01 0.1880 NA -0.116000 -0.148000 2.87e-01 1.76e-01
Toll-like Receptor Cascades 127 1.29e-03 5.45e-03 0.1880 NA -0.184000 0.035800 3.38e-04 4.86e-01
CDK-mediated phosphorylation and removal of Cdc6 68 2.74e-02 5.97e-02 0.1880 NA -0.105000 -0.156000 1.36e-01 2.64e-02
Arachidonic acid metabolism 35 1.57e-01 2.36e-01 0.1870 NA 0.153000 0.108000 1.17e-01 2.69e-01
Platelet homeostasis 52 6.59e-02 1.18e-01 0.1870 NA -0.048300 0.181000 5.47e-01 2.41e-02
Thrombin signalling through proteinase activated receptors (PARs) 20 3.52e-01 4.48e-01 0.1870 NA -0.165000 0.088500 2.02e-01 4.93e-01
Vitamin D (calciferol) metabolism 10 5.93e-01 6.73e-01 0.1870 NA -0.040000 0.183000 8.27e-01 3.17e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 15 4.60e-01 5.50e-01 0.1860 NA -0.177000 0.056800 2.34e-01 7.04e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 17 4.12e-01 5.03e-01 0.1860 NA -0.133000 -0.130000 3.41e-01 3.54e-01
Mitochondrial Fatty Acid Beta-Oxidation 31 2.01e-01 2.87e-01 0.1860 NA 0.183000 -0.033200 7.77e-02 7.49e-01
Cell surface interactions at the vascular wall 84 1.34e-02 3.47e-02 0.1860 NA -0.115000 0.146000 6.89e-02 2.06e-02
SUMOylation of transcription factors 16 4.35e-01 5.25e-01 0.1860 NA -0.091700 -0.162000 5.25e-01 2.63e-01
Regulation of localization of FOXO transcription factors 12 5.39e-01 6.23e-01 0.1860 NA -0.083800 0.166000 6.15e-01 3.20e-01
Signaling by NOTCH4 79 1.67e-02 4.09e-02 0.1860 NA -0.157000 -0.099000 1.58e-02 1.28e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 67 3.14e-02 6.69e-02 0.1860 NA -0.181000 -0.040500 1.03e-02 5.67e-01
Viral Messenger RNA Synthesis 43 1.08e-01 1.74e-01 0.1860 NA -0.058600 -0.176000 5.07e-01 4.55e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 5.11e-01 5.99e-01 0.1860 NA 0.182000 0.037200 2.57e-01 8.16e-01
Mitotic Spindle Checkpoint 105 4.74e-03 1.56e-02 0.1850 NA 0.171000 -0.072200 2.53e-03 2.02e-01
Downstream signal transduction 28 2.37e-01 3.30e-01 0.1850 NA -0.185000 -0.006660 9.00e-02 9.51e-01
G1/S DNA Damage Checkpoints 64 3.72e-02 7.62e-02 0.1850 NA -0.146000 -0.113000 4.31e-02 1.17e-01
Protein-protein interactions at synapses 55 5.92e-02 1.10e-01 0.1850 NA 0.088900 0.162000 2.54e-01 3.75e-02
Diseases of glycosylation 108 4.11e-03 1.39e-02 0.1850 NA 0.017600 0.184000 7.52e-01 9.74e-04
GAB1 signalosome 13 5.19e-01 6.06e-01 0.1840 NA -0.180000 0.037600 2.62e-01 8.15e-01
Signaling by FGFR2 IIIa TM 18 4.03e-01 4.95e-01 0.1830 NA -0.004720 0.183000 9.72e-01 1.78e-01
Diseases of signal transduction 332 7.94e-08 1.18e-06 0.1830 NA -0.182000 0.015100 1.19e-08 6.38e-01
Post-translational modification: synthesis of GPI-anchored proteins 44 1.11e-01 1.78e-01 0.1820 NA 0.146000 0.110000 9.48e-02 2.08e-01
G alpha (i) signalling events 195 6.83e-05 4.88e-04 0.1820 NA 0.013600 0.182000 7.44e-01 1.27e-05
Metabolism of vitamins and cofactors 157 4.51e-04 2.34e-03 0.1820 NA 0.061600 -0.171000 1.83e-01 2.16e-04
Signaling by WNT 236 1.00e-05 9.93e-05 0.1820 NA -0.182000 -0.003090 1.61e-06 9.35e-01
G beta:gamma signalling through CDC42 11 5.82e-01 6.64e-01 0.1810 NA -0.045900 0.176000 7.92e-01 3.13e-01
Mitotic Prophase 95 9.34e-03 2.60e-02 0.1810 NA -0.043500 -0.176000 4.64e-01 3.03e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins 13 5.29e-01 6.16e-01 0.1810 NA 0.102000 -0.150000 5.23e-01 3.50e-01
tRNA processing in the mitochondrion 35 1.80e-01 2.63e-01 0.1810 NA 0.102000 -0.150000 2.96e-01 1.25e-01
COPI-dependent Golgi-to-ER retrograde traffic 77 2.34e-02 5.32e-02 0.1810 NA -0.136000 0.120000 3.91e-02 6.97e-02
Glycosphingolipid metabolism 37 1.63e-01 2.43e-01 0.1810 NA -0.176000 0.043200 6.41e-02 6.50e-01
Mitotic Prometaphase 177 1.85e-04 1.13e-03 0.1810 NA 0.179000 -0.027400 4.10e-05 5.31e-01
Cargo trafficking to the periciliary membrane 48 9.60e-02 1.57e-01 0.1810 NA 0.000417 0.181000 9.96e-01 3.04e-02
Gap-filling DNA repair synthesis and ligation in GG-NER 25 2.94e-01 3.88e-01 0.1810 NA 0.176000 0.039600 1.27e-01 7.32e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 2.22e-01 3.13e-01 0.1800 NA -0.141000 -0.111000 1.73e-01 2.86e-01
Platelet activation, signaling and aggregation 192 1.09e-04 7.23e-04 0.1790 NA -0.118000 0.136000 5.02e-03 1.22e-03
activated TAK1 mediates p38 MAPK activation 19 4.01e-01 4.94e-01 0.1790 NA -0.178000 0.021800 1.80e-01 8.69e-01
MASTL Facilitates Mitotic Progression 10 6.18e-01 6.96e-01 0.1790 NA -0.053400 -0.171000 7.70e-01 3.50e-01
HSF1 activation 26 2.89e-01 3.82e-01 0.1780 NA -0.165000 -0.066900 1.45e-01 5.55e-01
DCC mediated attractive signaling 13 5.42e-01 6.26e-01 0.1780 NA -0.052700 0.170000 7.42e-01 2.90e-01
G2/M DNA damage checkpoint 67 4.27e-02 8.48e-02 0.1770 NA 0.175000 0.026400 1.31e-02 7.08e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 6.25e-01 7.02e-01 0.1770 NA -0.016500 -0.176000 9.28e-01 3.34e-01
Centrosome maturation 80 2.42e-02 5.42e-02 0.1760 NA 0.170000 0.046600 8.62e-03 4.72e-01
Recruitment of mitotic centrosome proteins and complexes 80 2.42e-02 5.42e-02 0.1760 NA 0.170000 0.046600 8.62e-03 4.72e-01
Cyclin A:Cdk2-associated events at S phase entry 82 2.19e-02 5.08e-02 0.1760 NA -0.136000 -0.112000 3.28e-02 8.11e-02
Interleukin-2 family signaling 29 2.65e-01 3.62e-01 0.1750 NA -0.139000 0.107000 1.96e-01 3.17e-01
Transcriptional regulation by small RNAs 61 6.03e-02 1.11e-01 0.1750 NA -0.064800 -0.163000 3.81e-01 2.80e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 4.38e-01 5.28e-01 0.1750 NA 0.032200 -0.172000 8.13e-01 2.06e-01
Extracellular matrix organization 190 1.74e-04 1.07e-03 0.1750 NA 0.053500 0.167000 2.04e-01 7.63e-05
Resolution of Sister Chromatid Cohesion 101 1.02e-02 2.79e-02 0.1750 NA 0.159000 -0.073600 5.89e-03 2.01e-01
VLDLR internalisation and degradation 12 5.80e-01 6.62e-01 0.1740 NA -0.166000 0.051800 3.18e-01 7.56e-01
Synaptic adhesion-like molecules 15 5.05e-01 5.94e-01 0.1740 NA 0.145000 0.095400 3.30e-01 5.22e-01
Meiotic recombination 36 1.96e-01 2.81e-01 0.1740 NA 0.166000 0.051800 8.51e-02 5.91e-01
RNA Polymerase III Chain Elongation 18 4.43e-01 5.32e-01 0.1740 NA -0.173000 -0.018900 2.05e-01 8.90e-01
MHC class II antigen presentation 84 2.33e-02 5.29e-02 0.1740 NA -0.113000 0.132000 7.36e-02 3.68e-02
Neddylation 210 8.05e-05 5.63e-04 0.1740 NA -0.102000 -0.140000 1.06e-02 4.72e-04
Beta-catenin independent WNT signaling 123 4.06e-03 1.39e-02 0.1740 NA -0.171000 0.030300 1.07e-03 5.62e-01
Transport of small molecules 540 7.91e-11 1.89e-09 0.1730 NA -0.157000 0.071600 5.03e-10 4.61e-03
VEGFR2 mediated vascular permeability 26 3.14e-01 4.09e-01 0.1720 NA -0.171000 -0.022900 1.31e-01 8.40e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 59 7.24e-02 1.25e-01 0.1720 NA -0.167000 -0.043100 2.67e-02 5.67e-01
Termination of translesion DNA synthesis 31 2.50e-01 3.45e-01 0.1720 NA 0.121000 0.123000 2.45e-01 2.36e-01
Asymmetric localization of PCP proteins 59 7.27e-02 1.26e-01 0.1720 NA -0.155000 -0.074100 3.92e-02 3.25e-01
Transcriptional regulation by RUNX2 102 1.13e-02 3.03e-02 0.1720 NA -0.172000 0.002570 2.74e-03 9.64e-01
Sialic acid metabolism 22 3.80e-01 4.76e-01 0.1720 NA -0.151000 0.082500 2.21e-01 5.03e-01
Late Phase of HIV Life Cycle 129 3.38e-03 1.20e-02 0.1720 NA -0.095800 -0.143000 6.06e-02 5.22e-03
Signaling by NTRK3 (TRKC) 14 5.38e-01 6.23e-01 0.1720 NA -0.163000 -0.053500 2.91e-01 7.29e-01
Signaling by Hedgehog 122 4.83e-03 1.59e-02 0.1720 NA -0.165000 0.048200 1.70e-03 3.58e-01
MAP2K and MAPK activation 35 2.18e-01 3.08e-01 0.1710 NA -0.154000 0.074100 1.15e-01 4.48e-01
IKK complex recruitment mediated by RIP1 21 4.01e-01 4.94e-01 0.1700 NA -0.166000 -0.039100 1.89e-01 7.57e-01
Branched-chain amino acid catabolism 21 4.03e-01 4.95e-01 0.1700 NA 0.163000 -0.047500 1.95e-01 7.07e-01
Signaling by NTRK2 (TRKB) 21 4.06e-01 4.97e-01 0.1700 NA -0.095700 0.140000 4.48e-01 2.66e-01
Regulation of beta-cell development 30 2.76e-01 3.72e-01 0.1700 NA 0.079600 -0.150000 4.51e-01 1.55e-01
Regulation of TNFR1 signaling 30 2.76e-01 3.72e-01 0.1690 NA -0.155000 -0.068000 1.43e-01 5.19e-01
Base-Excision Repair, AP Site Formation 31 2.69e-01 3.65e-01 0.1690 NA 0.158000 -0.060100 1.29e-01 5.62e-01
NOTCH1 Intracellular Domain Regulates Transcription 45 1.47e-01 2.23e-01 0.1690 NA -0.162000 -0.046300 6.00e-02 5.91e-01
TNFR1-induced proapoptotic signaling 12 6.01e-01 6.80e-01 0.1680 NA -0.003530 -0.168000 9.83e-01 3.13e-01
Cellular responses to stress 341 6.83e-07 9.39e-06 0.1680 NA -0.117000 -0.120000 2.05e-04 1.44e-04
Diseases of carbohydrate metabolism 30 2.82e-01 3.77e-01 0.1680 NA -0.014500 -0.167000 8.91e-01 1.13e-01
Signaling by cytosolic FGFR1 fusion mutants 18 4.69e-01 5.57e-01 0.1670 NA -0.164000 -0.034800 2.29e-01 7.98e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 108 1.09e-02 2.95e-02 0.1670 NA -0.044300 -0.161000 4.27e-01 3.78e-03
APC/C-mediated degradation of cell cycle proteins 82 3.30e-02 6.95e-02 0.1670 NA 0.000978 -0.167000 9.88e-01 8.99e-03
Regulation of mitotic cell cycle 82 3.30e-02 6.95e-02 0.1670 NA 0.000978 -0.167000 9.88e-01 8.99e-03
HIV Infection 215 1.43e-04 9.02e-04 0.1660 NA -0.127000 -0.107000 1.35e-03 6.74e-03
Olfactory Signaling Pathway 11 6.34e-01 7.12e-01 0.1660 NA 0.092400 0.138000 5.96e-01 4.29e-01
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 116 8.72e-03 2.51e-02 0.1650 NA -0.061800 -0.153000 2.51e-01 4.35e-03
Neutrophil degranulation 354 7.66e-07 1.04e-05 0.1650 NA -0.130000 0.102000 2.81e-05 1.04e-03
HIV Life Cycle 141 3.24e-03 1.16e-02 0.1650 NA -0.074600 -0.147000 1.26e-01 2.58e-03
Keratan sulfate biosynthesis 18 4.83e-01 5.71e-01 0.1650 NA -0.125000 0.107000 3.58e-01 4.32e-01
Activation of BH3-only proteins 29 3.09e-01 4.04e-01 0.1650 NA -0.161000 0.036100 1.35e-01 7.36e-01
Signaling by high-kinase activity BRAF mutants 31 2.87e-01 3.81e-01 0.1640 NA -0.162000 0.029000 1.19e-01 7.80e-01
PPARA activates gene expression 114 1.02e-02 2.79e-02 0.1640 NA -0.059400 -0.153000 2.73e-01 4.83e-03
Golgi-to-ER retrograde transport 108 1.35e-02 3.48e-02 0.1640 NA -0.138000 0.087700 1.30e-02 1.16e-01
ER-Phagosome pathway 79 4.23e-02 8.42e-02 0.1630 NA -0.153000 -0.057800 1.88e-02 3.75e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 3.56e-02 7.38e-02 0.1630 NA 0.075500 -0.145000 2.32e-01 2.17e-02
Synthesis of PC 25 3.67e-01 4.62e-01 0.1630 NA -0.161000 -0.030100 1.64e-01 7.95e-01
Nucleotide salvage 20 4.49e-01 5.39e-01 0.1630 NA 0.103000 0.126000 4.25e-01 3.28e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 5.31e-01 6.17e-01 0.1630 NA 0.155000 -0.050000 2.84e-01 7.29e-01
NRIF signals cell death from the nucleus 15 5.53e-01 6.36e-01 0.1630 NA -0.155000 0.049600 2.99e-01 7.39e-01
Formation of the beta-catenin:TCF transactivating complex 45 1.69e-01 2.50e-01 0.1630 NA -0.162000 -0.007060 5.95e-02 9.35e-01
Antigen processing-Cross presentation 89 2.97e-02 6.39e-02 0.1620 NA -0.155000 -0.047800 1.14e-02 4.36e-01
Signaling by NOTCH 177 1.00e-03 4.44e-03 0.1620 NA -0.160000 -0.025800 2.47e-04 5.54e-01
Plasma lipoprotein remodeling 27 3.51e-01 4.47e-01 0.1610 NA 0.094400 -0.131000 3.96e-01 2.39e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 5.57e-01 6.40e-01 0.1610 NA -0.001460 0.161000 9.92e-01 2.79e-01
Activation of HOX genes during differentiation 70 6.61e-02 1.18e-01 0.1610 NA -0.159000 -0.023900 2.13e-02 7.30e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 6.61e-02 1.18e-01 0.1610 NA -0.159000 -0.023900 2.13e-02 7.30e-01
Apoptosis induced DNA fragmentation 10 6.80e-01 7.50e-01 0.1610 NA 0.141000 -0.076500 4.39e-01 6.76e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 89 3.30e-02 6.95e-02 0.1600 NA 0.158000 -0.027500 9.99e-03 6.54e-01
Amplification of signal from the kinetochores 89 3.30e-02 6.95e-02 0.1600 NA 0.158000 -0.027500 9.99e-03 6.54e-01
SLC-mediated transmembrane transport 176 1.35e-03 5.67e-03 0.1590 NA -0.134000 0.086500 2.21e-03 4.80e-02
Antigen processing: Ubiquitination & Proteasome degradation 281 3.10e-05 2.55e-04 0.1580 NA -0.103000 -0.120000 3.08e-03 5.65e-04
Regulation of FOXO transcriptional activity by acetylation 10 6.87e-01 7.56e-01 0.1580 NA -0.122000 -0.100000 5.06e-01 5.82e-01
Hemostasis 420 2.63e-07 3.79e-06 0.1570 NA -0.077800 0.137000 6.41e-03 1.62e-06
Factors involved in megakaryocyte development and platelet production 106 2.04e-02 4.78e-02 0.1570 NA -0.030500 0.154000 5.88e-01 6.15e-03
Surfactant metabolism 12 6.43e-01 7.18e-01 0.1570 NA -0.101000 0.120000 5.44e-01 4.71e-01
TRAF6 mediated IRF7 activation 14 5.96e-01 6.76e-01 0.1570 NA -0.141000 -0.068200 3.60e-01 6.59e-01
Gene Silencing by RNA 83 4.70e-02 9.17e-02 0.1570 NA -0.071600 -0.139000 2.60e-01 2.82e-02
Zinc transporters 14 5.99e-01 6.79e-01 0.1570 NA -0.152000 0.038800 3.26e-01 8.01e-01
Signaling by RAS mutants 51 1.57e-01 2.36e-01 0.1560 NA -0.142000 0.065800 8.06e-02 4.16e-01
Visual phototransduction 72 7.27e-02 1.26e-01 0.1560 NA 0.065200 0.142000 3.39e-01 3.80e-02
Listeria monocytogenes entry into host cells 18 5.22e-01 6.09e-01 0.1560 NA -0.131000 0.084400 3.37e-01 5.35e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 6.72e-01 7.43e-01 0.1550 NA -0.053800 0.146000 7.57e-01 4.02e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 31 3.25e-01 4.20e-01 0.1550 NA -0.101000 -0.118000 3.31e-01 2.56e-01
Molecules associated with elastic fibres 19 5.04e-01 5.92e-01 0.1550 NA 0.053700 0.145000 6.85e-01 2.73e-01
ISG15 antiviral mechanism 72 7.56e-02 1.30e-01 0.1550 NA -0.087900 -0.127000 1.98e-01 6.21e-02
Apoptotic factor-mediated response 16 5.66e-01 6.49e-01 0.1540 NA -0.054700 0.144000 7.05e-01 3.17e-01
Non-integrin membrane-ECM interactions 37 2.69e-01 3.65e-01 0.1540 NA -0.118000 0.099700 2.15e-01 2.94e-01
Innate Immune System 740 1.32e-11 3.55e-10 0.1540 NA -0.140000 0.065000 1.28e-10 2.77e-03
Plasma lipoprotein assembly 17 5.49e-01 6.33e-01 0.1530 NA -0.005610 -0.153000 9.68e-01 2.74e-01
Signaling by Nuclear Receptors 184 1.60e-03 6.53e-03 0.1530 NA -0.146000 -0.047700 6.62e-04 2.65e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 21 4.78e-01 5.66e-01 0.1530 NA -0.089200 -0.124000 4.79e-01 3.25e-01
Death Receptor Signalling 123 1.38e-02 3.54e-02 0.1530 NA -0.147000 -0.042500 5.00e-03 4.16e-01
G beta:gamma signalling through PI3Kgamma 14 6.13e-01 6.92e-01 0.1530 NA -0.143000 -0.053000 3.54e-01 7.32e-01
GRB2 events in ERBB2 signaling 12 6.60e-01 7.32e-01 0.1520 NA -0.100000 0.115000 5.48e-01 4.90e-01
Activation of Matrix Metalloproteinases 16 5.72e-01 6.55e-01 0.1520 NA 0.066900 0.137000 6.43e-01 3.44e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 56 1.46e-01 2.22e-01 0.1520 NA -0.147000 0.036400 5.67e-02 6.38e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 56 1.46e-01 2.22e-01 0.1520 NA -0.147000 0.036400 5.67e-02 6.38e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 56 1.46e-01 2.22e-01 0.1520 NA -0.147000 0.036400 5.67e-02 6.38e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 56 1.46e-01 2.22e-01 0.1520 NA -0.147000 0.036400 5.67e-02 6.38e-01
Signaling by NOTCH1 in Cancer 56 1.46e-01 2.22e-01 0.1520 NA -0.147000 0.036400 5.67e-02 6.38e-01
Processing of DNA double-strand break ends 69 9.52e-02 1.56e-01 0.1510 NA 0.149000 0.024700 3.26e-02 7.23e-01
Class I MHC mediated antigen processing & presentation 335 1.28e-05 1.22e-04 0.1510 NA -0.116000 -0.096200 2.68e-04 2.53e-03
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 7.11e-01 7.78e-01 0.1510 NA 0.147000 0.031800 4.20e-01 8.62e-01
RNA polymerase II transcribes snRNA genes 72 8.93e-02 1.50e-01 0.1500 NA -0.140000 -0.052400 3.98e-02 4.43e-01
B-WICH complex positively regulates rRNA expression 46 2.13e-01 3.03e-01 0.1500 NA -0.121000 -0.087900 1.56e-01 3.02e-01
Smooth Muscle Contraction 27 4.11e-01 5.02e-01 0.1490 NA -0.061800 0.135000 5.79e-01 2.24e-01
Metabolism of nucleotides 87 5.89e-02 1.09e-01 0.1480 NA 0.111000 -0.097600 7.26e-02 1.16e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 26 4.24e-01 5.15e-01 0.1480 NA -0.104000 -0.105000 3.57e-01 3.54e-01
RUNX2 regulates bone development 24 4.59e-01 5.50e-01 0.1470 NA 0.022500 0.145000 8.49e-01 2.18e-01
RNA Polymerase I Promoter Clearance 65 1.23e-01 1.94e-01 0.1470 NA -0.028400 -0.144000 6.92e-01 4.47e-02
Disease 885 1.64e-12 4.93e-11 0.1470 NA -0.139000 -0.045700 2.77e-12 2.20e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 39 2.87e-01 3.81e-01 0.1460 NA -0.131000 -0.064000 1.56e-01 4.89e-01
HIV Transcription Elongation 39 2.87e-01 3.81e-01 0.1460 NA -0.131000 -0.064000 1.56e-01 4.89e-01
Tat-mediated elongation of the HIV-1 transcript 39 2.87e-01 3.81e-01 0.1460 NA -0.131000 -0.064000 1.56e-01 4.89e-01
Signaling by NOTCH2 29 3.97e-01 4.92e-01 0.1460 NA -0.013700 0.145000 8.99e-01 1.76e-01
Cleavage of the damaged pyrimidine 29 3.98e-01 4.92e-01 0.1460 NA 0.143000 -0.028300 1.83e-01 7.92e-01
Depyrimidination 29 3.98e-01 4.92e-01 0.1460 NA 0.143000 -0.028300 1.83e-01 7.92e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 29 3.98e-01 4.92e-01 0.1460 NA 0.143000 -0.028300 1.83e-01 7.92e-01
Epigenetic regulation of gene expression 102 3.90e-02 7.91e-02 0.1460 NA -0.089700 -0.115000 1.18e-01 4.54e-02
Post-translational protein modification 1153 1.32e-15 5.07e-14 0.1460 NA -0.130000 -0.064900 1.45e-13 2.33e-04
Signaling by FGFR1 in disease 30 3.87e-01 4.82e-01 0.1460 NA -0.143000 0.026800 1.75e-01 8.00e-01
Collagen formation 52 1.91e-01 2.76e-01 0.1450 NA 0.100000 0.105000 2.11e-01 1.89e-01
Caspase-mediated cleavage of cytoskeletal proteins 11 7.08e-01 7.75e-01 0.1450 NA 0.013800 0.144000 9.37e-01 4.09e-01
DNA methylation 19 5.51e-01 6.35e-01 0.1440 NA 0.078200 0.121000 5.55e-01 3.60e-01
Peptide hormone metabolism 50 2.14e-01 3.03e-01 0.1440 NA -0.126000 0.069900 1.24e-01 3.92e-01
Regulation of RUNX1 Expression and Activity 18 5.70e-01 6.53e-01 0.1440 NA -0.108000 -0.095200 4.27e-01 4.85e-01
Nucleotide Excision Repair 110 3.40e-02 7.10e-02 0.1440 NA 0.016000 -0.143000 7.72e-01 9.72e-03
COPI-independent Golgi-to-ER retrograde traffic 31 3.86e-01 4.82e-01 0.1430 NA -0.143000 0.007900 1.68e-01 9.39e-01
Metabolism of steroids 122 2.48e-02 5.49e-02 0.1430 NA 0.072800 -0.123000 1.66e-01 1.90e-02
G alpha (12/13) signalling events 60 1.64e-01 2.44e-01 0.1420 NA -0.121000 0.074900 1.05e-01 3.16e-01
NRAGE signals death through JNK 49 2.29e-01 3.21e-01 0.1420 NA -0.125000 0.067700 1.31e-01 4.12e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 5.30e-01 6.16e-01 0.1420 NA -0.130000 -0.057100 3.03e-01 6.51e-01
Neurodegenerative Diseases 21 5.30e-01 6.16e-01 0.1420 NA -0.130000 -0.057100 3.03e-01 6.51e-01
Apoptosis 157 9.01e-03 2.56e-02 0.1420 NA -0.123000 -0.070200 7.82e-03 1.29e-01
G0 and Early G1 26 4.58e-01 5.49e-01 0.1410 NA 0.130000 0.055500 2.51e-01 6.25e-01
Formation of HIV elongation complex in the absence of HIV Tat 41 2.94e-01 3.88e-01 0.1410 NA -0.119000 -0.074900 1.86e-01 4.07e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 6.58e-01 7.30e-01 0.1410 NA -0.057000 -0.129000 7.12e-01 4.04e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 11 7.21e-01 7.86e-01 0.1410 NA 0.049900 0.131000 7.74e-01 4.50e-01
Signaling by WNT in cancer 31 4.00e-01 4.94e-01 0.1400 NA -0.139000 -0.021900 1.82e-01 8.33e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 29 4.26e-01 5.17e-01 0.1400 NA -0.129000 -0.054900 2.30e-01 6.09e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 50 2.34e-01 3.26e-01 0.1400 NA -0.112000 0.083700 1.71e-01 3.06e-01
Translesion synthesis by POLK 17 6.09e-01 6.89e-01 0.1390 NA 0.057300 0.127000 6.83e-01 3.65e-01
Gene expression (Transcription) 1265 1.88e-15 7.00e-14 0.1390 NA -0.030700 -0.135000 6.89e-02 1.05e-15
RAB GEFs exchange GTP for GDP on RABs 83 9.31e-02 1.55e-01 0.1390 NA -0.118000 0.073600 6.41e-02 2.47e-01
FGFR1 mutant receptor activation 23 5.17e-01 6.05e-01 0.1390 NA -0.135000 0.031100 2.62e-01 7.96e-01
Interleukin-35 Signalling 11 7.31e-01 7.91e-01 0.1380 NA -0.078600 0.114000 6.52e-01 5.13e-01
Signal Transduction 1625 1.75e-18 1.11e-16 0.1370 NA -0.109000 0.082300 4.77e-13 4.79e-08
Translesion synthesis by POLI 17 6.20e-01 6.98e-01 0.1370 NA 0.071700 0.116000 6.09e-01 4.07e-01
Signaling by Non-Receptor Tyrosine Kinases 46 2.78e-01 3.73e-01 0.1370 NA -0.136000 0.009730 1.10e-01 9.09e-01
Signaling by PTK6 46 2.78e-01 3.73e-01 0.1370 NA -0.136000 0.009730 1.10e-01 9.09e-01
RNA Polymerase II Pre-transcription Events 75 1.24e-01 1.95e-01 0.1360 NA -0.134000 -0.022300 4.42e-02 7.39e-01
Interleukin-6 family signaling 19 5.94e-01 6.74e-01 0.1350 NA -0.116000 -0.069200 3.82e-01 6.01e-01
Cell death signalling via NRAGE, NRIF and NADE 65 1.72e-01 2.54e-01 0.1350 NA -0.130000 0.034700 6.96e-02 6.29e-01
Glycolysis 65 1.73e-01 2.55e-01 0.1340 NA -0.130000 -0.035000 7.11e-02 6.26e-01
Signaling by NODAL 14 6.85e-01 7.54e-01 0.1340 NA -0.092500 -0.097000 5.49e-01 5.30e-01
TNF signaling 40 3.45e-01 4.42e-01 0.1330 NA -0.077300 -0.108000 3.98e-01 2.37e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 3.50e-01 4.46e-01 0.1330 NA -0.129000 0.032400 1.59e-01 7.23e-01
Signaling by moderate kinase activity BRAF mutants 40 3.50e-01 4.46e-01 0.1330 NA -0.129000 0.032400 1.59e-01 7.23e-01
TRAF3-dependent IRF activation pathway 12 7.30e-01 7.91e-01 0.1320 NA -0.124000 0.047100 4.58e-01 7.77e-01
RNA Polymerase I Transcription 66 1.78e-01 2.60e-01 0.1320 NA -0.034500 -0.127000 6.28e-01 7.35e-02
Josephin domain DUBs 11 7.50e-01 8.07e-01 0.1320 NA -0.017300 -0.131000 9.21e-01 4.53e-01
Mitotic Anaphase 173 1.18e-02 3.12e-02 0.1320 NA 0.045100 -0.124000 3.07e-01 5.03e-03
Mitotic Metaphase and Anaphase 174 1.15e-02 3.08e-02 0.1320 NA 0.042100 -0.125000 3.39e-01 4.58e-03
Programmed Cell Death 160 1.66e-02 4.07e-02 0.1310 NA -0.114000 -0.063800 1.26e-02 1.64e-01
RHO GTPases activate PKNs 45 3.17e-01 4.12e-01 0.1310 NA -0.106000 0.076800 2.18e-01 3.73e-01
Regulation of PLK1 Activity at G2/M Transition 86 1.12e-01 1.79e-01 0.1300 NA 0.127000 0.029300 4.17e-02 6.38e-01
Cytochrome c-mediated apoptotic response 13 7.20e-01 7.86e-01 0.1300 NA -0.099000 0.084400 5.37e-01 5.98e-01
Deactivation of the beta-catenin transactivating complex 40 3.62e-01 4.58e-01 0.1300 NA -0.127000 -0.029600 1.66e-01 7.46e-01
Phospholipid metabolism 167 1.56e-02 3.87e-02 0.1300 NA -0.112000 0.065800 1.27e-02 1.43e-01
Growth hormone receptor signaling 20 6.06e-01 6.86e-01 0.1300 NA 0.098800 -0.084000 4.44e-01 5.16e-01
Retinoid metabolism and transport 38 3.86e-01 4.82e-01 0.1290 NA 0.108000 0.070300 2.48e-01 4.53e-01
Heme biosynthesis 10 7.79e-01 8.31e-01 0.1290 NA 0.045200 0.121000 8.05e-01 5.09e-01
Glycogen metabolism 25 5.38e-01 6.23e-01 0.1280 NA -0.078200 -0.102000 4.99e-01 3.79e-01
eNOS activation 11 7.64e-01 8.19e-01 0.1280 NA 0.071000 -0.107000 6.84e-01 5.40e-01
Dual Incision in GG-NER 41 3.66e-01 4.61e-01 0.1280 NA 0.127000 -0.019200 1.61e-01 8.32e-01
Hedgehog ‘off’ state 92 1.06e-01 1.72e-01 0.1280 NA -0.123000 0.035600 4.17e-02 5.56e-01
Intrinsic Pathway for Apoptosis 49 3.08e-01 4.03e-01 0.1270 NA -0.122000 0.034400 1.39e-01 6.77e-01
Oncogenic MAPK signaling 72 1.82e-01 2.65e-01 0.1260 NA -0.107000 0.067100 1.17e-01 3.25e-01
Separation of Sister Chromatids 162 2.31e-02 5.28e-02 0.1250 NA 0.051100 -0.114000 2.62e-01 1.20e-02
Interleukin-20 family signaling 15 7.02e-01 7.71e-01 0.1250 NA 0.125000 0.002050 4.01e-01 9.89e-01
Antiviral mechanism by IFN-stimulated genes 80 1.53e-01 2.32e-01 0.1250 NA -0.106000 -0.066700 1.02e-01 3.03e-01
Interleukin-6 signaling 10 7.91e-01 8.41e-01 0.1250 NA -0.125000 0.006050 4.94e-01 9.74e-01
Translesion Synthesis by POLH 19 6.40e-01 7.18e-01 0.1250 NA 0.075200 0.099700 5.71e-01 4.52e-01
Inflammasomes 17 6.73e-01 7.43e-01 0.1250 NA -0.002260 0.125000 9.87e-01 3.73e-01
DNA Replication 122 5.97e-02 1.10e-01 0.1250 NA 0.125000 -0.000644 1.76e-02 9.90e-01
VxPx cargo-targeting to cilium 18 6.61e-01 7.32e-01 0.1240 NA -0.091600 0.084000 5.01e-01 5.37e-01
p130Cas linkage to MAPK signaling for integrins 13 7.42e-01 7.99e-01 0.1240 NA 0.019700 -0.122000 9.02e-01 4.45e-01
RNA Polymerase II Transcription 1138 2.72e-11 7.03e-10 0.1240 NA -0.026800 -0.121000 1.31e-01 1.04e-11
Cytochrome P450 - arranged by substrate type 41 3.94e-01 4.89e-01 0.1230 NA 0.090100 -0.084500 3.18e-01 3.50e-01
SLC transporter disorders 68 2.12e-01 3.01e-01 0.1230 NA -0.063300 -0.106000 3.67e-01 1.32e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 3.52e-01 4.49e-01 0.1230 NA -0.034100 -0.118000 6.89e-01 1.66e-01
Cell Cycle Checkpoints 254 3.80e-03 1.31e-02 0.1220 NA 0.116000 -0.037100 1.45e-03 3.09e-01
TP53 Regulates Transcription of DNA Repair Genes 58 2.75e-01 3.71e-01 0.1220 NA -0.064500 -0.103000 3.96e-01 1.74e-01
Signaling by Hippo 20 6.42e-01 7.18e-01 0.1220 NA -0.118000 -0.027800 3.60e-01 8.30e-01
Cytokine Signaling in Immune system 478 3.59e-05 2.89e-04 0.1210 NA -0.120000 -0.016500 7.51e-06 5.37e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 14 7.35e-01 7.94e-01 0.1210 NA -0.078000 -0.092300 6.13e-01 5.50e-01
DNA Repair 286 2.23e-03 8.76e-03 0.1210 NA 0.102000 -0.063900 2.97e-03 6.34e-02
Transcriptional Regulation by TP53 345 6.41e-04 3.09e-03 0.1200 NA -0.093400 -0.075600 2.94e-03 1.62e-02
Immune System 1388 2.11e-12 6.21e-11 0.1190 NA -0.115000 0.031500 1.44e-12 5.21e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 15 7.29e-01 7.91e-01 0.1190 NA 0.031100 -0.115000 8.35e-01 4.43e-01
Peptide ligand-binding receptors 47 3.73e-01 4.69e-01 0.1190 NA -0.044200 0.110000 6.00e-01 1.92e-01
Transport of bile salts and organic acids, metal ions and amine compounds 58 2.98e-01 3.92e-01 0.1180 NA -0.118000 -0.011400 1.22e-01 8.81e-01
Adaptive Immune System 565 1.61e-05 1.44e-04 0.1160 NA -0.113000 0.026000 4.55e-06 2.92e-01
Apoptotic cleavage of cellular proteins 32 5.30e-01 6.16e-01 0.1150 NA -0.114000 -0.014800 2.64e-01 8.85e-01
STING mediated induction of host immune responses 12 7.88e-01 8.37e-01 0.1150 NA -0.028800 -0.111000 8.63e-01 5.04e-01
Interleukin-15 signaling 14 7.59e-01 8.15e-01 0.1150 NA -0.071600 0.090000 6.43e-01 5.60e-01
Switching of origins to a post-replicative state 86 1.85e-01 2.67e-01 0.1150 NA -0.002350 -0.115000 9.70e-01 6.61e-02
Organelle biogenesis and maintenance 248 7.91e-03 2.34e-02 0.1150 NA 0.080100 0.082000 3.02e-02 2.65e-02
Oxidative Stress Induced Senescence 77 2.27e-01 3.19e-01 0.1140 NA -0.112000 -0.018800 8.96e-02 7.76e-01
The citric acid (TCA) cycle and respiratory electron transport 152 5.42e-02 1.03e-01 0.1140 NA -0.018000 -0.112000 7.02e-01 1.72e-02
DNA Double Strand Break Response 47 4.04e-01 4.95e-01 0.1130 NA -0.047700 -0.103000 5.72e-01 2.23e-01
SLBP independent Processing of Histone Pre-mRNAs 10 8.27e-01 8.64e-01 0.1130 NA 0.082300 -0.077100 6.52e-01 6.73e-01
Reproduction 72 2.54e-01 3.49e-01 0.1130 NA 0.085400 0.073500 2.11e-01 2.81e-01
M Phase 322 2.54e-03 9.75e-03 0.1130 NA 0.058600 -0.096100 7.12e-02 3.10e-03
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 51 3.81e-01 4.76e-01 0.1120 NA -0.104000 -0.043500 2.01e-01 5.91e-01
RUNX3 regulates NOTCH signaling 14 7.69e-01 8.23e-01 0.1120 NA -0.111000 0.012100 4.71e-01 9.38e-01
Orc1 removal from chromatin 67 2.83e-01 3.78e-01 0.1120 NA -0.061500 -0.093600 3.84e-01 1.85e-01
Triglyceride biosynthesis 11 8.13e-01 8.59e-01 0.1120 NA 0.097000 0.055900 5.77e-01 7.48e-01
Synthesis of PE 11 8.15e-01 8.60e-01 0.1110 NA -0.100000 -0.047900 5.65e-01 7.83e-01
Interconversion of nucleotide di- and triphosphates 26 6.21e-01 6.98e-01 0.1110 NA 0.032100 -0.106000 7.77e-01 3.49e-01
Synthesis of DNA 115 1.24e-01 1.95e-01 0.1100 NA 0.107000 -0.026200 4.70e-02 6.28e-01
Oncogene Induced Senescence 34 5.38e-01 6.23e-01 0.1100 NA -0.042500 -0.102000 6.68e-01 3.05e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 5.01e-01 5.91e-01 0.1100 NA 0.047400 0.099300 6.13e-01 2.90e-01
Transport of vitamins, nucleosides, and related molecules 33 5.53e-01 6.36e-01 0.1090 NA 0.106000 0.028800 2.94e-01 7.75e-01
Stimuli-sensing channels 58 3.56e-01 4.52e-01 0.1090 NA -0.094800 0.054600 2.12e-01 4.72e-01
SIRT1 negatively regulates rRNA expression 23 6.65e-01 7.35e-01 0.1090 NA -0.025500 -0.106000 8.32e-01 3.80e-01
Signaling by FGFR in disease 50 4.14e-01 5.05e-01 0.1090 NA -0.101000 0.040600 2.17e-01 6.20e-01
Formation of apoptosome 11 8.24e-01 8.64e-01 0.1080 NA -0.104000 0.031500 5.51e-01 8.56e-01
Regulation of the apoptosome activity 11 8.24e-01 8.64e-01 0.1080 NA -0.104000 0.031500 5.51e-01 8.56e-01
Detoxification of Reactive Oxygen Species 27 6.25e-01 7.02e-01 0.1080 NA -0.066200 -0.084900 5.52e-01 4.45e-01
Regulation of IFNG signaling 13 8.01e-01 8.48e-01 0.1070 NA 0.092200 -0.054500 5.65e-01 7.34e-01
Signaling by BRAF and RAF fusions 58 3.75e-01 4.71e-01 0.1070 NA -0.073800 0.077100 3.31e-01 3.10e-01
Cell Cycle 555 1.19e-04 7.70e-04 0.1060 NA 0.102000 -0.029000 4.21e-05 2.45e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 8.05e-01 8.52e-01 0.1050 NA 0.080900 0.067200 6.13e-01 6.75e-01
Caspase activation via extrinsic apoptotic signalling pathway 22 6.94e-01 7.62e-01 0.1050 NA -0.043500 -0.095700 7.24e-01 4.37e-01
Degradation of the extracellular matrix 68 3.27e-01 4.22e-01 0.1050 NA -0.049400 0.092800 4.81e-01 1.86e-01
Translesion synthesis by REV1 16 7.67e-01 8.21e-01 0.1050 NA 0.029300 0.101000 8.39e-01 4.85e-01
Formation of the Early Elongation Complex 33 5.79e-01 6.62e-01 0.1050 NA -0.103000 -0.019500 3.05e-01 8.46e-01
Formation of the HIV-1 Early Elongation Complex 33 5.79e-01 6.62e-01 0.1050 NA -0.103000 -0.019500 3.05e-01 8.46e-01
Pyruvate metabolism 25 6.62e-01 7.33e-01 0.1050 NA 0.058500 0.086800 6.13e-01 4.53e-01
Interleukin-4 and Interleukin-13 signaling 65 3.46e-01 4.43e-01 0.1040 NA -0.099000 -0.033100 1.68e-01 6.45e-01
Transcriptional Regulation by MECP2 46 4.76e-01 5.64e-01 0.1040 NA -0.103000 0.015500 2.28e-01 8.56e-01
Xenobiotics 15 7.85e-01 8.36e-01 0.1030 NA 0.067900 0.078000 6.49e-01 6.01e-01
IL-6-type cytokine receptor ligand interactions 13 8.13e-01 8.59e-01 0.1030 NA -0.092100 -0.045600 5.65e-01 7.76e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 6.42e-01 7.18e-01 0.1030 NA -0.091200 -0.047000 4.04e-01 6.67e-01
RNA Polymerase I Transcription Termination 31 6.14e-01 6.93e-01 0.1030 NA 0.011000 -0.102000 9.16e-01 3.26e-01
Generic Transcription Pathway 1019 3.51e-07 4.93e-06 0.1020 NA -0.011200 -0.101000 5.51e-01 6.09e-08
Cell Cycle, Mitotic 461 9.95e-04 4.42e-03 0.1020 NA 0.091700 -0.043700 7.70e-04 1.09e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 3.02e-01 3.96e-01 0.1010 NA -0.038500 -0.093600 5.57e-01 1.53e-01
Ca2+ pathway 47 5.03e-01 5.91e-01 0.0991 NA -0.045900 0.087900 5.86e-01 2.97e-01
Collagen degradation 23 7.13e-01 7.79e-01 0.0990 NA -0.011200 -0.098300 9.26e-01 4.14e-01
Integrin alphaIIb beta3 signaling 24 7.04e-01 7.71e-01 0.0989 NA -0.097900 0.013800 4.06e-01 9.07e-01
Integrin signaling 24 7.04e-01 7.71e-01 0.0989 NA -0.097900 0.013800 4.06e-01 9.07e-01
Metalloprotease DUBs 22 7.28e-01 7.91e-01 0.0982 NA 0.021000 -0.096000 8.65e-01 4.36e-01
Cellular Senescence 139 1.37e-01 2.12e-01 0.0979 NA -0.038800 -0.089900 4.31e-01 6.75e-02
Triglyceride metabolism 23 7.20e-01 7.86e-01 0.0978 NA -0.028200 0.093600 8.15e-01 4.37e-01
Signaling by Rho GTPases 346 8.74e-03 2.51e-02 0.0968 NA -0.033700 0.090700 2.82e-01 3.84e-03
Regulation of TP53 Activity through Phosphorylation 86 3.01e-01 3.95e-01 0.0968 NA 0.096700 -0.001060 1.21e-01 9.86e-01
Metal ion SLC transporters 22 7.38e-01 7.95e-01 0.0963 NA -0.084200 0.046800 4.94e-01 7.04e-01
Metabolism of steroid hormones 22 7.36e-01 7.94e-01 0.0962 NA 0.082700 0.049200 5.02e-01 6.90e-01
NOD1/2 Signaling Pathway 31 6.56e-01 7.29e-01 0.0952 NA -0.088700 -0.034400 3.93e-01 7.40e-01
Negative regulators of DDX58/IFIH1 signaling 33 6.42e-01 7.18e-01 0.0949 NA -0.044700 0.083700 6.57e-01 4.05e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 11 8.65e-01 8.96e-01 0.0940 NA -0.033200 0.088000 8.49e-01 6.13e-01
Laminin interactions 21 7.59e-01 8.15e-01 0.0937 NA 0.000923 0.093700 9.94e-01 4.57e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 14 8.36e-01 8.70e-01 0.0923 NA -0.030700 -0.087000 8.42e-01 5.73e-01
Downregulation of ERBB2 signaling 24 7.37e-01 7.95e-01 0.0919 NA -0.086100 -0.032400 4.66e-01 7.84e-01
Protein ubiquitination 70 4.16e-01 5.07e-01 0.0913 NA -0.077700 -0.048100 2.61e-01 4.87e-01
Transcriptional Regulation by E2F6 34 6.56e-01 7.29e-01 0.0912 NA 0.011300 -0.090500 9.09e-01 3.62e-01
Citric acid cycle (TCA cycle) 21 7.71e-01 8.25e-01 0.0908 NA -0.029900 -0.085700 8.12e-01 4.97e-01
Plasma lipoprotein assembly, remodeling, and clearance 63 4.64e-01 5.54e-01 0.0903 NA -0.089800 -0.009210 2.18e-01 8.99e-01
Gluconeogenesis 30 6.94e-01 7.62e-01 0.0900 NA 0.017400 0.088300 8.69e-01 4.02e-01
G2/M Checkpoints 137 1.97e-01 2.82e-01 0.0894 NA 0.087700 -0.017200 7.65e-02 7.28e-01
Assembly of the pre-replicative complex 65 4.60e-01 5.50e-01 0.0891 NA -0.063900 -0.062200 3.73e-01 3.86e-01
Pre-NOTCH Expression and Processing 64 4.68e-01 5.57e-01 0.0890 NA -0.088500 -0.009870 2.21e-01 8.91e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 5.46e-01 6.30e-01 0.0889 NA -0.058500 -0.066900 4.70e-01 4.08e-01
Amyloid fiber formation 53 5.38e-01 6.23e-01 0.0884 NA 0.012600 0.087500 8.74e-01 2.71e-01
S Phase 155 1.70e-01 2.52e-01 0.0879 NA 0.067000 -0.056900 1.50e-01 2.22e-01
Meiosis 63 4.84e-01 5.72e-01 0.0878 NA 0.087600 0.005510 2.29e-01 9.40e-01
Transcription of the HIV genome 64 4.80e-01 5.68e-01 0.0875 NA -0.086900 -0.010300 2.29e-01 8.87e-01
RNA Polymerase I Promoter Escape 46 5.91e-01 6.73e-01 0.0873 NA -0.012300 -0.086500 8.85e-01 3.11e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 47 5.90e-01 6.72e-01 0.0868 NA -0.079200 0.035400 3.48e-01 6.75e-01
Diseases associated with glycosylation precursor biosynthesis 18 8.22e-01 8.64e-01 0.0854 NA -0.036700 0.077200 7.88e-01 5.71e-01
Regulation of TP53 Activity through Association with Co-factors 12 8.78e-01 9.07e-01 0.0854 NA -0.066000 0.054100 6.92e-01 7.46e-01
Formation of tubulin folding intermediates by CCT/TriC 23 7.81e-01 8.32e-01 0.0847 NA 0.005680 0.084500 9.62e-01 4.83e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 8.34e-01 8.69e-01 0.0845 NA 0.084200 -0.006660 5.48e-01 9.62e-01
Regulation of MECP2 expression and activity 29 7.33e-01 7.93e-01 0.0843 NA -0.060200 -0.059000 5.75e-01 5.82e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 5.14e-01 6.02e-01 0.0834 NA -0.009990 -0.082800 8.90e-01 2.52e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 19 8.25e-01 8.64e-01 0.0822 NA -0.077800 -0.026500 5.57e-01 8.41e-01
Apoptotic execution phase 43 6.48e-01 7.23e-01 0.0819 NA -0.065600 -0.049000 4.57e-01 5.79e-01
Metabolism of fat-soluble vitamins 42 6.57e-01 7.29e-01 0.0816 NA 0.044400 0.068500 6.19e-01 4.43e-01
AKT phosphorylates targets in the nucleus 10 9.06e-01 9.27e-01 0.0815 NA -0.045400 0.067700 8.04e-01 7.11e-01
RHO GTPases Activate Formins 115 3.30e-01 4.24e-01 0.0804 NA 0.078600 0.017000 1.46e-01 7.54e-01
PI3K events in ERBB2 signaling 12 8.92e-01 9.18e-01 0.0797 NA -0.053100 -0.059400 7.50e-01 7.22e-01
The NLRP3 inflammasome 13 8.87e-01 9.16e-01 0.0781 NA 0.055700 0.054700 7.28e-01 7.33e-01
Glycerophospholipid biosynthesis 97 4.26e-01 5.17e-01 0.0768 NA -0.002250 0.076800 9.69e-01 1.92e-01
Regulation of TP53 Activity 150 2.68e-01 3.64e-01 0.0767 NA -0.051000 -0.057300 2.82e-01 2.26e-01
Platelet Aggregation (Plug Formation) 28 7.84e-01 8.35e-01 0.0759 NA -0.060100 -0.046400 5.82e-01 6.71e-01
Prefoldin mediated transfer of substrate to CCT/TriC 27 7.97e-01 8.45e-01 0.0750 NA -0.071100 0.023800 5.22e-01 8.31e-01
ERBB2 Regulates Cell Motility 11 9.11e-01 9.31e-01 0.0749 NA -0.074200 -0.010200 6.70e-01 9.53e-01
Condensation of Prophase Chromosomes 27 8.00e-01 8.47e-01 0.0743 NA -0.003350 -0.074200 9.76e-01 5.04e-01
Pentose phosphate pathway 13 9.01e-01 9.24e-01 0.0731 NA 0.069500 0.022400 6.64e-01 8.89e-01
Cleavage of the damaged purine 24 8.28e-01 8.64e-01 0.0724 NA 0.072200 -0.005490 5.41e-01 9.63e-01
Depurination 24 8.28e-01 8.64e-01 0.0724 NA 0.072200 -0.005490 5.41e-01 9.63e-01
Recognition and association of DNA glycosylase with site containing an affected purine 24 8.28e-01 8.64e-01 0.0724 NA 0.072200 -0.005490 5.41e-01 9.63e-01
Downregulation of ERBB2:ERBB3 signaling 13 9.03e-01 9.25e-01 0.0723 NA -0.045100 -0.056500 7.78e-01 7.24e-01
Signaling by BMP 18 8.69e-01 9.00e-01 0.0723 NA 0.018200 -0.069900 8.94e-01 6.07e-01
Cyclin D associated events in G1 42 7.31e-01 7.91e-01 0.0708 NA -0.032000 0.063200 7.19e-01 4.79e-01
G1 Phase 42 7.31e-01 7.91e-01 0.0708 NA -0.032000 0.063200 7.19e-01 4.79e-01
NoRC negatively regulates rRNA expression 61 6.52e-01 7.27e-01 0.0686 NA -0.064400 0.023600 3.84e-01 7.50e-01
Negative epigenetic regulation of rRNA expression 64 6.43e-01 7.18e-01 0.0679 NA -0.067300 -0.008870 3.52e-01 9.02e-01
Dual incision in TC-NER 65 6.54e-01 7.29e-01 0.0660 NA -0.019000 -0.063200 7.92e-01 3.78e-01
Senescence-Associated Secretory Phenotype (SASP) 62 6.76e-01 7.46e-01 0.0649 NA -0.010700 -0.064100 8.84e-01 3.83e-01
Metabolism of carbohydrates 242 2.27e-01 3.19e-01 0.0644 NA -0.011400 0.063400 7.60e-01 8.99e-02
G2/M Transition 177 3.41e-01 4.37e-01 0.0642 NA 0.026900 -0.058200 5.37e-01 1.82e-01
Mitotic G2-G2/M phases 179 3.39e-01 4.35e-01 0.0639 NA 0.032100 -0.055300 4.59e-01 2.03e-01
Nuclear signaling by ERBB4 19 8.93e-01 9.18e-01 0.0629 NA -0.041400 -0.047300 7.55e-01 7.21e-01
IRF3-mediated induction of type I IFN 10 9.42e-01 9.58e-01 0.0628 NA -0.062000 -0.010400 7.34e-01 9.55e-01
DNA Damage/Telomere Stress Induced Senescence 43 7.79e-01 8.31e-01 0.0624 NA 0.007490 -0.061900 9.32e-01 4.82e-01
DNA Damage Bypass 47 7.61e-01 8.17e-01 0.0623 NA 0.006200 0.061900 9.41e-01 4.63e-01
TNFs bind their physiological receptors 11 9.40e-01 9.57e-01 0.0611 NA 0.059100 -0.015600 7.34e-01 9.29e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 8.64e-01 8.96e-01 0.0602 NA -0.049100 0.034900 6.59e-01 7.53e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 8.64e-01 8.96e-01 0.0602 NA -0.049100 0.034900 6.59e-01 7.53e-01
Signaling by Retinoic Acid 32 8.45e-01 8.79e-01 0.0594 NA 0.053900 -0.024800 5.98e-01 8.08e-01
RHO GTPase Effectors 237 2.94e-01 3.88e-01 0.0592 NA -0.022000 0.055000 5.60e-01 1.46e-01
Response to elevated platelet cytosolic Ca2+ 107 5.90e-01 6.72e-01 0.0576 NA -0.007750 0.057100 8.90e-01 3.08e-01
Metabolism 1715 6.29e-04 3.07e-03 0.0566 NA 0.002030 -0.056500 8.91e-01 1.24e-04
Class I peroxisomal membrane protein import 18 9.17e-01 9.37e-01 0.0566 NA 0.009000 -0.055800 9.47e-01 6.82e-01
Metabolism of nitric oxide: eNOS activation and regulation 15 9.31e-01 9.49e-01 0.0563 NA -0.055500 0.009550 7.10e-01 9.49e-01
PRC2 methylates histones and DNA 28 8.76e-01 9.07e-01 0.0561 NA -0.006450 0.055800 9.53e-01 6.10e-01
HIV Transcription Initiation 45 8.28e-01 8.64e-01 0.0530 NA -0.020400 0.049000 8.13e-01 5.70e-01
RNA Polymerase II HIV Promoter Escape 45 8.28e-01 8.64e-01 0.0530 NA -0.020400 0.049000 8.13e-01 5.70e-01
RNA Polymerase II Promoter Escape 45 8.28e-01 8.64e-01 0.0530 NA -0.020400 0.049000 8.13e-01 5.70e-01
RNA Polymerase II Transcription Initiation 45 8.28e-01 8.64e-01 0.0530 NA -0.020400 0.049000 8.13e-01 5.70e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 8.28e-01 8.64e-01 0.0530 NA -0.020400 0.049000 8.13e-01 5.70e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 8.28e-01 8.64e-01 0.0530 NA -0.020400 0.049000 8.13e-01 5.70e-01
Notch-HLH transcription pathway 27 8.93e-01 9.18e-01 0.0530 NA 0.000537 -0.053000 9.96e-01 6.33e-01
Recognition of DNA damage by PCNA-containing replication complex 30 8.87e-01 9.16e-01 0.0515 NA 0.035000 0.037800 7.40e-01 7.20e-01
Chaperonin-mediated protein folding 81 7.31e-01 7.91e-01 0.0509 NA -0.050900 0.003000 4.29e-01 9.63e-01
Depolymerisation of the Nuclear Lamina 15 9.52e-01 9.67e-01 0.0464 NA -0.028200 -0.036900 8.50e-01 8.05e-01
ADP signalling through P2Y purinoceptor 1 13 9.63e-01 9.75e-01 0.0443 NA -0.032400 0.030200 8.39e-01 8.50e-01
mRNA Capping 29 9.22e-01 9.41e-01 0.0433 NA -0.025300 0.035100 8.14e-01 7.43e-01
Transcription of E2F targets under negative control by DREAM complex 19 9.50e-01 9.65e-01 0.0424 NA 0.042400 0.000454 7.49e-01 9.97e-01
Platelet degranulation 102 7.73e-01 8.26e-01 0.0412 NA -0.013400 0.038900 8.15e-01 4.97e-01
Pre-NOTCH Transcription and Translation 48 8.90e-01 9.18e-01 0.0402 NA -0.040200 -0.001450 6.30e-01 9.86e-01
NOTCH4 Intracellular Domain Regulates Transcription 18 9.58e-01 9.71e-01 0.0397 NA 0.034700 0.019300 7.99e-01 8.87e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 48 9.02e-01 9.24e-01 0.0380 NA 0.037100 -0.008150 6.56e-01 9.22e-01
Interferon Signaling 156 7.23e-01 7.87e-01 0.0374 NA 0.035800 0.010800 4.41e-01 8.16e-01
RNA Polymerase I Promoter Opening 18 9.64e-01 9.76e-01 0.0370 NA -0.030500 0.021000 8.23e-01 8.77e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 9.09e-01 9.30e-01 0.0364 NA 0.007630 -0.035600 9.27e-01 6.69e-01
G1/S Transition 127 7.94e-01 8.42e-01 0.0350 NA 0.012800 -0.032600 8.04e-01 5.26e-01
Protein folding 87 8.57e-01 8.90e-01 0.0344 NA -0.033800 -0.006590 5.86e-01 9.15e-01
Prostacyclin signalling through prostacyclin receptor 10 9.83e-01 9.89e-01 0.0343 NA -0.032100 0.012100 8.61e-01 9.47e-01
Amino acid synthesis and interconversion (transamination) 27 9.56e-01 9.69e-01 0.0336 NA -0.031800 0.010900 7.75e-01 9.22e-01
Cytosolic iron-sulfur cluster assembly 11 9.83e-01 9.89e-01 0.0322 NA 0.025200 -0.020000 8.85e-01 9.09e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 23 9.66e-01 9.77e-01 0.0319 NA 0.024600 -0.020300 8.39e-01 8.66e-01
Packaging Of Telomere Ends 20 9.72e-01 9.81e-01 0.0309 NA -0.010700 0.029000 9.34e-01 8.23e-01
Interleukin-27 signaling 10 9.86e-01 9.90e-01 0.0302 NA -0.026500 0.014500 8.85e-01 9.37e-01
Glucose metabolism 84 8.95e-01 9.20e-01 0.0297 NA -0.029700 -0.000616 6.38e-01 9.92e-01
Mitotic G1-G1/S phases 144 8.47e-01 8.81e-01 0.0278 NA 0.027600 -0.003730 5.68e-01 9.38e-01
Diseases associated with the TLR signaling cascade 19 9.79e-01 9.86e-01 0.0275 NA 0.024200 -0.013100 8.55e-01 9.21e-01
Diseases of Immune System 19 9.79e-01 9.86e-01 0.0275 NA 0.024200 -0.013100 8.55e-01 9.21e-01
Regulation of innate immune responses to cytosolic DNA 13 9.88e-01 9.91e-01 0.0251 NA -0.015000 0.020100 9.26e-01 9.00e-01
DNA Replication Pre-Initiation 81 9.35e-01 9.52e-01 0.0236 NA 0.023100 -0.004890 7.19e-01 9.39e-01
Signaling by PDGF 44 9.69e-01 9.79e-01 0.0220 NA 0.012200 -0.018300 8.89e-01 8.34e-01
Meiotic synapsis 42 9.75e-01 9.84e-01 0.0201 NA -0.018200 0.008390 8.38e-01 9.25e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 30 9.85e-01 9.89e-01 0.0187 NA -0.013300 0.013100 9.00e-01 9.01e-01
Nucleobase catabolism 29 9.90e-01 9.92e-01 0.0155 NA 0.009960 -0.011800 9.26e-01 9.12e-01
Aflatoxin activation and detoxification 16 9.96e-01 9.97e-01 0.0131 NA -0.010100 0.008420 9.44e-01 9.53e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 9.97e-01 9.97e-01 0.0127 NA -0.003180 -0.012300 9.85e-01 9.44e-01
Glycogen breakdown (glycogenolysis) 15 9.97e-01 9.97e-01 0.0113 NA -0.010500 0.004190 9.44e-01 9.78e-01
Metabolism of lipids 595 8.98e-01 9.22e-01 0.0112 NA -0.011000 -0.001930 6.48e-01 9.36e-01


Detailed Gene set reports

Cholesterol biosynthesis

metric value
setSize 23
pMANOVA 1.7e-10
p.adjustMANOVA 3.84e-09
s.dist 0.808
confESp NA
s.rna_LGvHG 0.805
s.rna_HGvHGV -0.0701
p.rna_LGvHG 2.3e-11
p.rna_HGvHGV 0.561




Gene rna_LGvHG rna_HGvHGV
ACAT2 7985 -7382
EBP 5785 -6196
HMGCS1 8742 -3997
DHCR24 6318 -5310
MVD 8659 -3281
HMGCR 8727 -3195
GGPS1 6064 -3613
FDPS 8061 -2067
CYP51A1 3372 -4591
PMVK 3615 -2364
IDI1 8739 -801
FDFT1 8601 -300
DHCR7 8697 -210

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
ACAT2 7985 -7382
ARV1 8319 4878
CYP51A1 3372 -4591
DHCR24 6318 -5310
DHCR7 8697 -210
EBP 5785 -6196
FDFT1 8601 -300
FDPS 8061 -2067
GGPS1 6064 -3613
HMGCR 8727 -3195
HMGCS1 8742 -3997
HSD17B7 3746 2663
IDI1 8739 -801
LBR 3742 6516
LSS 8539 2564
MSMO1 8761 2198
MVD 8659 -3281
MVK 8707 5459
NSDHL 7139 385
PMVK 3615 -2364
SC5D 5863 5250
SQLE 8745 2221
TM7SF2 7722 5510



Unwinding of DNA

metric value
setSize 12
pMANOVA 2.54e-05
p.adjustMANOVA 0.000214
s.dist 0.766
confESp NA
s.rna_LGvHG 0.727
s.rna_HGvHGV 0.241
p.rna_LGvHG 1.31e-05
p.rna_HGvHGV 0.148




Gene rna_LGvHG rna_HGvHGV
GINS2 8043 6509
GINS4 7227 7228
MCM6 7978 5285
GINS1 8709 2886
MCM4 7711 2998
MCM8 4139 4674
MCM3 5224 3032
GINS3 8290 1867
CDC45 2134 4411

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
CDC45 2134 4411
GINS1 8709 2886
GINS2 8043 6509
GINS3 8290 1867
GINS4 7227 7228
MCM2 7882 -1372
MCM3 5224 3032
MCM4 7711 2998
MCM5 8187 -4273
MCM6 7978 5285
MCM7 2748 -5668
MCM8 4139 4674



Synthesis of bile acids and bile salts via 27-hydroxycholesterol

metric value
setSize 13
pMANOVA 3.85e-05
p.adjustMANOVA 0.000299
s.dist 0.721
confESp NA
s.rna_LGvHG -0.226
s.rna_HGvHGV -0.684
p.rna_LGvHG 0.157
p.rna_HGvHGV 1.93e-05




Gene rna_LGvHG rna_HGvHGV
NR1H4 -6340 -7816
AKR1C1 -7566 -6322
AKR1C2 -7548 -4937
CYP27A1 -3778 -7686
RXRA -4174 -4604
CYP7A1 -1258 -6439

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
AKR1C1 -7566 -6322
AKR1C2 -7548 -4937
AKR1C3 1231 -6662
AKR1C4 6259 -2719
AKR1D1 2518 -2590
CYP27A1 -3778 -7686
CYP7A1 -1258 -6439
CYP8B1 1240 -7451
HSD3B7 2625 -7730
NCOA1 -4821 3973
NCOA2 5080 -7532
NR1H4 -6340 -7816
RXRA -4174 -4604



Initial triggering of complement

metric value
setSize 13
pMANOVA 7.58e-05
p.adjustMANOVA 0.000533
s.dist 0.7
confESp NA
s.rna_LGvHG 0.517
s.rna_HGvHGV -0.471
p.rna_LGvHG 0.00124
p.rna_HGvHGV 0.0033




Gene rna_LGvHG rna_HGvHGV
CFB 8729 -7311
MBL2 8047 -7655
C4A 8681 -6810
C4B 8711 -6742
C3 8728 -6117
MASP2 6191 -7729
C2 6852 -6555
C1S 8732 -3917

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rna_LGvHG rna_HGvHGV
C1R 8598 4950
C1S 8732 -3917
C2 6852 -6555
C3 8728 -6117
C4A 8681 -6810
C4B 8711 -6742
CFB 8729 -7311
CFD 7680 7259
COLEC11 -6295 -5894
GZMM -5541 4024
MASP1 -6560 -3299
MASP2 6191 -7729
MBL2 8047 -7655



Regulation of Complement cascade

metric value
setSize 30
pMANOVA 1.14e-09
p.adjustMANOVA 2.37e-08
s.dist 0.678
confESp NA
s.rna_LGvHG 0.553
s.rna_HGvHGV -0.392
p.rna_LGvHG 1.54e-07
p.rna_HGvHGV 0.000201




Gene rna_LGvHG rna_HGvHGV
C8A 8567 -7471
CFB 8729 -7311
C4A 8681 -6810
C4B 8711 -6742
C3 8728 -6117
VTN 7938 -6681
C8B 8713 -5759
C2 6852 -6555
C5 8502 -4693
C1S 8732 -3917
C5AR1 7700 -4399
PROS1 6797 -4877
CFI 7992 -3805
C4BPA 5528 -4859
CPB2 4713 -5233
C6 8413 -1808
CD46 5474 -888
F2 720 -6133
CPN2 111 -7786
CPN1 4092 -10

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
C1R 8598 4950
C1S 8732 -3917
C2 6852 -6555
C3 8728 -6117
C4A 8681 -6810
C4B 8711 -6742
C4BPA 5528 -4859
C4BPB -7122 -7765
C5 8502 -4693
C5AR1 7700 -4399
C5AR2 3105 7415
C6 8413 -1808
C7 6582 90
C8A 8567 -7471
C8B 8713 -5759
C8G -1770 -3042
CD19 3213 7350
CD46 5474 -888
CD55 -6972 1417
CD59 -3108 2472
CFB 8729 -7311
CFI 7992 -3805
CLU 6074 2492
CPB2 4713 -5233
CPN1 4092 -10
CPN2 111 -7786
F2 720 -6133
PROS1 6797 -4877
SERPING1 8763 144
VTN 7938 -6681



Voltage gated Potassium channels

metric value
setSize 14
pMANOVA 0.000101
p.adjustMANOVA 0.000683
s.dist 0.663
confESp NA
s.rna_LGvHG -0.109
s.rna_HGvHGV 0.654
p.rna_LGvHG 0.478
p.rna_HGvHGV 2.29e-05




Gene rna_LGvHG rna_HGvHGV
KCNH2 -6220 8485
KCNH3 -5257 8414
KCNF1 -6475 2508
KCNG2 -4493 3057
KCND1 -1948 4898
KCNG3 -2020 3504
KCNC3 -707 7769

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rna_LGvHG rna_HGvHGV
KCNAB1 -1871 -1382
KCNAB2 977 5887
KCNAB3 2822 5606
KCNC1 4841 8317
KCNC3 -707 7769
KCNC4 6148 7016
KCND1 -1948 4898
KCNF1 -6475 2508
KCNG2 -4493 3057
KCNG3 -2020 3504
KCNH2 -6220 8485
KCNH3 -5257 8414
KCNH6 3658 7193
KCNS3 6143 8116



Adenylate cyclase inhibitory pathway

metric value
setSize 11
pMANOVA 0.000798
p.adjustMANOVA 0.00372
s.dist 0.658
confESp NA
s.rna_LGvHG -0.02
s.rna_HGvHGV 0.657
p.rna_LGvHG 0.908
p.rna_HGvHGV 0.000159




Gene rna_LGvHG rna_HGvHGV
GNAI2 -4148 6292
GNAI1 -3147 7957
ADCY4 -2129 8096
ADCY6 -2788 4142
GNAI3 -4547 2520

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rna_LGvHG rna_HGvHGV
ADCY1 5005 6062
ADCY3 1790 7964
ADCY4 -2129 8096
ADCY5 404 6796
ADCY6 -2788 4142
ADCY7 4340 7148
ADCY9 4596 234
GNAI1 -3147 7957
GNAI2 -4148 6292
GNAI3 -4547 2520
GNAL 5208 5528



Calnexin/calreticulin cycle

metric value
setSize 26
pMANOVA 9.81e-08
p.adjustMANOVA 1.44e-06
s.dist 0.643
confESp NA
s.rna_LGvHG -0.64
s.rna_HGvHGV -0.0676
p.rna_LGvHG 1.64e-08
p.rna_HGvHGV 0.551




Gene rna_LGvHG rna_HGvHGV
DERL2 -7492 -5988
CANX -7544 -4761
PDIA3 -7547 -4672
PRKCSH -6303 -4165
MAN1B1 -3754 -5405
MARCH6 -3796 -5054
UGGT1 -7364 -2124
RNF5 -7255 -905
RPS27A -2775 -2092
AMFR -4049 -1070
RNF139 -2883 -826

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rna_LGvHG rna_HGvHGV
AMFR -4049 -1070
CALR -7600 3622
CANX -7544 -4761
DERL2 -7492 -5988
EDEM1 -7562 4754
EDEM2 -5920 3449
EDEM3 -1724 3539
GANAB 2891 -5477
MAN1B1 -3754 -5405
MARCH6 -3796 -5054
OS9 -7438 4312
PDIA3 -7547 -4672
PRKCSH -6303 -4165
RNF103 -6285 4554
RNF139 -2883 -826
RNF185 -6322 3615
RNF5 -7255 -905
RPS27A -2775 -2092
SEL1L -7581 6447
SYVN1 -7570 4301
TRIM13 1936 -6313
UBA52 -5323 1252
UBB -3737 1627
UBC 931 -2324
UGGT1 -7364 -2124
UGGT2 1285 3828



Insulin receptor recycling

metric value
setSize 23
pMANOVA 1.32e-06
p.adjustMANOVA 1.71e-05
s.dist 0.628
confESp NA
s.rna_LGvHG -0.515
s.rna_HGvHGV 0.36
p.rna_LGvHG 1.9e-05
p.rna_HGvHGV 0.00283




Gene rna_LGvHG rna_HGvHGV
ATP6V1C2 -7299 7568
ATP6V0D1 -7372 7138
ATP6V0A1 -7400 6911
ATP6V1D -7342 6245
ATP6V1E1 -6599 6485
ATP6V0E1 -7056 5745
ATP6V0B -7527 4877
ATP6V1B2 -5777 4883
ATP6V1A -3869 6191
ATP6V1H -4617 4704
ATP6V1C1 -4984 3557
ATP6V0A4 -1514 8045
ATP6V1F -1466 6142
TCIRG1 -77 4001

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rna_LGvHG rna_HGvHGV
ATP6AP1 -6636 -3258
ATP6V0A1 -7400 6911
ATP6V0A2 -7288 -5276
ATP6V0A4 -1514 8045
ATP6V0B -7527 4877
ATP6V0C -3600 -2751
ATP6V0D1 -7372 7138
ATP6V0E1 -7056 5745
ATP6V0E2 6222 -4429
ATP6V1A -3869 6191
ATP6V1B1 6426 4649
ATP6V1B2 -5777 4883
ATP6V1C1 -4984 3557
ATP6V1C2 -7299 7568
ATP6V1D -7342 6245
ATP6V1E1 -6599 6485
ATP6V1E2 -514 -1244
ATP6V1F -1466 6142
ATP6V1G1 -5622 -198
ATP6V1G2 5807 7404
ATP6V1H -4617 4704
INSR -5354 -2269
TCIRG1 -77 4001



ER Quality Control Compartment (ERQC)

metric value
setSize 21
pMANOVA 4.99e-06
p.adjustMANOVA 5.49e-05
s.dist 0.623
confESp NA
s.rna_LGvHG -0.623
s.rna_HGvHGV 0.0158
p.rna_LGvHG 7.81e-07
p.rna_HGvHGV 0.9




Gene rna_LGvHG rna_HGvHGV
SEL1L -7581 6447
EDEM1 -7562 4754
SYVN1 -7570 4301
OS9 -7438 4312
RNF103 -6285 4554
RNF185 -6322 3615
EDEM2 -5920 3449
UBA52 -5323 1252
EDEM3 -1724 3539
UBB -3737 1627

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
AMFR -4049 -1070
DERL2 -7492 -5988
EDEM1 -7562 4754
EDEM2 -5920 3449
EDEM3 -1724 3539
MAN1B1 -3754 -5405
MARCH6 -3796 -5054
OS9 -7438 4312
RNF103 -6285 4554
RNF139 -2883 -826
RNF185 -6322 3615
RNF5 -7255 -905
RPS27A -2775 -2092
SEL1L -7581 6447
SYVN1 -7570 4301
TRIM13 1936 -6313
UBA52 -5323 1252
UBB -3737 1627
UBC 931 -2324
UGGT1 -7364 -2124
UGGT2 1285 3828



DNA strand elongation

metric value
setSize 32
pMANOVA 9.14e-09
p.adjustMANOVA 1.56e-07
s.dist 0.62
confESp NA
s.rna_LGvHG 0.566
s.rna_HGvHGV 0.254
p.rna_LGvHG 3.05e-08
p.rna_HGvHGV 0.0129




Gene rna_LGvHG rna_HGvHGV
GINS2 8043 6509
GINS4 7227 7228
PCNA 7628 6650
POLA2 8045 5393
MCM6 7978 5285
RPA3 7508 5460
PRIM2 7881 4246
POLD3 5051 6387
RFC3 5866 4409
RFC4 5223 4833
GINS1 8709 2886
PRIM1 8080 3036
MCM4 7711 2998
MCM8 4139 4674
MCM3 5224 3032
GINS3 8290 1867
POLA1 5502 2621
CDC45 2134 4411
RFC5 4510 1018
FEN1 227 5607

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rna_LGvHG rna_HGvHGV
CDC45 2134 4411
DNA2 3636 145
FEN1 227 5607
GINS1 8709 2886
GINS2 8043 6509
GINS3 8290 1867
GINS4 7227 7228
LIG1 7032 -3308
MCM2 7882 -1372
MCM3 5224 3032
MCM4 7711 2998
MCM5 8187 -4273
MCM6 7978 5285
MCM7 2748 -5668
MCM8 4139 4674
PCNA 7628 6650
POLA1 5502 2621
POLA2 8045 5393
POLD1 6487 -239
POLD2 5591 -120
POLD3 5051 6387
POLD4 -1918 4368
PRIM1 8080 3036
PRIM2 7881 4246
RFC1 -5197 -2428
RFC2 3968 172
RFC3 5866 4409
RFC4 5223 4833
RFC5 4510 1018
RPA1 -5058 2897
RPA2 8084 -1871
RPA3 7508 5460



Removal of the Flap Intermediate

metric value
setSize 14
pMANOVA 0.000301
p.adjustMANOVA 0.00172
s.dist 0.62
confESp NA
s.rna_LGvHG 0.512
s.rna_HGvHGV 0.349
p.rna_LGvHG 0.000909
p.rna_HGvHGV 0.0236




Gene rna_LGvHG rna_HGvHGV
PCNA 7628 6650
POLA2 8045 5393
RPA3 7508 5460
PRIM2 7881 4246
POLD3 5051 6387
PRIM1 8080 3036
POLA1 5502 2621
FEN1 227 5607
DNA2 3636 145

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
DNA2 3636 145
FEN1 227 5607
PCNA 7628 6650
POLA1 5502 2621
POLA2 8045 5393
POLD1 6487 -239
POLD2 5591 -120
POLD3 5051 6387
POLD4 -1918 4368
PRIM1 8080 3036
PRIM2 7881 4246
RPA1 -5058 2897
RPA2 8084 -1871
RPA3 7508 5460



Folding of actin by CCT/TriC

metric value
setSize 10
pMANOVA 0.00316
p.adjustMANOVA 0.0114
s.dist 0.618
confESp NA
s.rna_LGvHG -0.564
s.rna_HGvHGV -0.254
p.rna_LGvHG 0.00201
p.rna_HGvHGV 0.165




Gene rna_LGvHG rna_HGvHGV
CCT5 -6770 -6881
CCT2 -6103 -3420
CCT3 -2761 -4112
CCT8 -5885 -1394
CCT4 -1363 -4503
CCT7 -1288 -486
CCT6A -6111 -71

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rna_LGvHG rna_HGvHGV
ACTB -5090 3901
CCT2 -6103 -3420
CCT3 -2761 -4112
CCT4 -1363 -4503
CCT5 -6770 -6881
CCT6A -6111 -71
CCT6B 198 -4347
CCT7 -1288 -486
CCT8 -5885 -1394
TCP1 -5147 3821



Regulation of TLR by endogenous ligand

metric value
setSize 13
pMANOVA 0.000635
p.adjustMANOVA 0.00309
s.dist 0.615
confESp NA
s.rna_LGvHG 0.608
s.rna_HGvHGV -0.0953
p.rna_LGvHG 0.000148
p.rna_HGvHGV 0.552




Gene rna_LGvHG rna_HGvHGV
FGA 8712 -6806
FGG 7721 -7323
CD14 8472 -5148
FGB 8516 -5044
HMGB1 4058 -7241
LBP 8111 -2992

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rna_LGvHG rna_HGvHGV
APOB -2854 -1884
CD14 8472 -5148
CD36 7742 6440
FGA 8712 -6806
FGB 8516 -5044
FGG 7721 -7323
HMGB1 4058 -7241
LBP 8111 -2992
LY96 -1575 1059
S100A1 6558 4483
TLR1 7649 7144
TLR2 5490 5770
TLR6 3546 5654



Processive synthesis on the lagging strand

metric value
setSize 15
pMANOVA 0.000238
p.adjustMANOVA 0.00139
s.dist 0.608
confESp NA
s.rna_LGvHG 0.531
s.rna_HGvHGV 0.297
p.rna_LGvHG 0.000374
p.rna_HGvHGV 0.0467




Gene rna_LGvHG rna_HGvHGV
PCNA 7628 6650
POLA2 8045 5393
RPA3 7508 5460
PRIM2 7881 4246
POLD3 5051 6387
PRIM1 8080 3036
POLA1 5502 2621
FEN1 227 5607
DNA2 3636 145

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
DNA2 3636 145
FEN1 227 5607
LIG1 7032 -3308
PCNA 7628 6650
POLA1 5502 2621
POLA2 8045 5393
POLD1 6487 -239
POLD2 5591 -120
POLD3 5051 6387
POLD4 -1918 4368
PRIM1 8080 3036
PRIM2 7881 4246
RPA1 -5058 2897
RPA2 8084 -1871
RPA3 7508 5460



Leading Strand Synthesis

metric value
setSize 14
pMANOVA 0.000509
p.adjustMANOVA 0.0026
s.dist 0.6
confESp NA
s.rna_LGvHG 0.512
s.rna_HGvHGV 0.313
p.rna_LGvHG 0.000914
p.rna_HGvHGV 0.0429




Gene rna_LGvHG rna_HGvHGV
PCNA 7628 6650
POLA2 8045 5393
PRIM2 7881 4246
POLD3 5051 6387
RFC3 5866 4409
RFC4 5223 4833
PRIM1 8080 3036
POLA1 5502 2621
RFC5 4510 1018
RFC2 3968 172

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rna_LGvHG rna_HGvHGV
PCNA 7628 6650
POLA1 5502 2621
POLA2 8045 5393
POLD1 6487 -239
POLD2 5591 -120
POLD3 5051 6387
POLD4 -1918 4368
PRIM1 8080 3036
PRIM2 7881 4246
RFC1 -5197 -2428
RFC2 3968 172
RFC3 5866 4409
RFC4 5223 4833
RFC5 4510 1018



Polymerase switching

metric value
setSize 14
pMANOVA 0.000509
p.adjustMANOVA 0.0026
s.dist 0.6
confESp NA
s.rna_LGvHG 0.512
s.rna_HGvHGV 0.313
p.rna_LGvHG 0.000914
p.rna_HGvHGV 0.0429




Gene rna_LGvHG rna_HGvHGV
PCNA 7628 6650
POLA2 8045 5393
PRIM2 7881 4246
POLD3 5051 6387
RFC3 5866 4409
RFC4 5223 4833
PRIM1 8080 3036
POLA1 5502 2621
RFC5 4510 1018
RFC2 3968 172

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
PCNA 7628 6650
POLA1 5502 2621
POLA2 8045 5393
POLD1 6487 -239
POLD2 5591 -120
POLD3 5051 6387
POLD4 -1918 4368
PRIM1 8080 3036
PRIM2 7881 4246
RFC1 -5197 -2428
RFC2 3968 172
RFC3 5866 4409
RFC4 5223 4833
RFC5 4510 1018



Polymerase switching on the C-strand of the telomere

metric value
setSize 14
pMANOVA 0.000509
p.adjustMANOVA 0.0026
s.dist 0.6
confESp NA
s.rna_LGvHG 0.512
s.rna_HGvHGV 0.313
p.rna_LGvHG 0.000914
p.rna_HGvHGV 0.0429




Gene rna_LGvHG rna_HGvHGV
PCNA 7628 6650
POLA2 8045 5393
PRIM2 7881 4246
POLD3 5051 6387
RFC3 5866 4409
RFC4 5223 4833
PRIM1 8080 3036
POLA1 5502 2621
RFC5 4510 1018
RFC2 3968 172

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
PCNA 7628 6650
POLA1 5502 2621
POLA2 8045 5393
POLD1 6487 -239
POLD2 5591 -120
POLD3 5051 6387
POLD4 -1918 4368
PRIM1 8080 3036
PRIM2 7881 4246
RFC1 -5197 -2428
RFC2 3968 172
RFC3 5866 4409
RFC4 5223 4833
RFC5 4510 1018



Complement cascade

metric value
setSize 36
pMANOVA 4.92e-09
p.adjustMANOVA 8.76e-08
s.dist 0.597
confESp NA
s.rna_LGvHG 0.462
s.rna_HGvHGV -0.379
p.rna_LGvHG 1.65e-06
p.rna_HGvHGV 8.37e-05




Gene rna_LGvHG rna_HGvHGV
C8A 8567 -7471
CFB 8729 -7311
MBL2 8047 -7655
C4A 8681 -6810
C4B 8711 -6742
C3 8728 -6117
VTN 7938 -6681
C8B 8713 -5759
MASP2 6191 -7729
C2 6852 -6555
C5 8502 -4693
C1S 8732 -3917
C5AR1 7700 -4399
PROS1 6797 -4877
CFI 7992 -3805
C4BPA 5528 -4859
CPB2 4713 -5233
C6 8413 -1808
CD46 5474 -888
F2 720 -6133

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
C1R 8598 4950
C1S 8732 -3917
C2 6852 -6555
C3 8728 -6117
C4A 8681 -6810
C4B 8711 -6742
C4BPA 5528 -4859
C4BPB -7122 -7765
C5 8502 -4693
C5AR1 7700 -4399
C5AR2 3105 7415
C6 8413 -1808
C7 6582 90
C8A 8567 -7471
C8B 8713 -5759
C8G -1770 -3042
CD19 3213 7350
CD46 5474 -888
CD55 -6972 1417
CD59 -3108 2472
CFB 8729 -7311
CFD 7680 7259
CFI 7992 -3805
CLU 6074 2492
COLEC11 -6295 -5894
CPB2 4713 -5233
CPN1 4092 -10
CPN2 111 -7786
F2 720 -6133
GZMM -5541 4024
MASP1 -6560 -3299
MASP2 6191 -7729
MBL2 8047 -7655
PROS1 6797 -4877
SERPING1 8763 144
VTN 7938 -6681



MET activates RAS signaling

metric value
setSize 10
pMANOVA 0.00547
p.adjustMANOVA 0.0172
s.dist 0.591
confESp NA
s.rna_LGvHG -0.532
s.rna_HGvHGV 0.257
p.rna_LGvHG 0.00361
p.rna_HGvHGV 0.159




Gene rna_LGvHG rna_HGvHGV
SHC1 -7366 6063
MUC20 -4639 6658
HRAS -6243 2943
GRB2 -3760 4572
RANBP9 -7313 1487
KRAS -1531 5656
MET -7310 301

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
GRB2 -3760 4572
HRAS -6243 2943
KRAS -1531 5656
MET -7310 301
MUC20 -4639 6658
NRAS 2326 1987
RANBP10 -1044 -80
RANBP9 -7313 1487
SHC1 -7366 6063
SOS1 -791 -5263



Effects of PIP2 hydrolysis

metric value
setSize 21
pMANOVA 1.84e-05
p.adjustMANOVA 0.00016
s.dist 0.59
confESp NA
s.rna_LGvHG -0.251
s.rna_HGvHGV 0.534
p.rna_LGvHG 0.0465
p.rna_HGvHGV 2.29e-05




Gene rna_LGvHG rna_HGvHGV
ITPR3 -6578 6716
PRKCE -5962 7035
DGKZ -6347 5775
ITPR1 -4460 7498
PRKCD -5969 5212
DAGLA -7287 4051
DAGLB -4303 6669
ABHD12 -6689 3932
DGKE -6441 4008
PRKCH -2305 7766
DGKQ -2062 5700
DGKD -2395 568

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
ABHD12 -6689 3932
ABHD6 1113 7755
DAGLA -7287 4051
DAGLB -4303 6669
DGKA 7306 8110
DGKD -2395 568
DGKE -6441 4008
DGKG 1760 3885
DGKH 3524 7685
DGKK 7740 -7263
DGKQ -2062 5700
DGKZ -6347 5775
ITPR1 -4460 7498
ITPR2 1932 -4504
ITPR3 -6578 6716
PRKCD -5969 5212
PRKCE -5962 7035
PRKCH -2305 7766
PRKCQ 2905 7047
RASGRP1 2601 2419
RASGRP2 1024 8411



N-glycan trimming in the ER and Calnexin/Calreticulin cycle

metric value
setSize 35
pMANOVA 2.07e-08
p.adjustMANOVA 3.36e-07
s.dist 0.58
confESp NA
s.rna_LGvHG -0.575
s.rna_HGvHGV -0.0809
p.rna_LGvHG 3.96e-09
p.rna_HGvHGV 0.408




Gene rna_LGvHG rna_HGvHGV
DERL2 -7492 -5988
CANX -7544 -4761
PDIA3 -7547 -4672
VCP -7126 -4707
PRKCSH -6303 -4165
MAN1B1 -3754 -5405
MARCH6 -3796 -5054
UGGT1 -7364 -2124
NGLY1 -2840 -3002
MOGS -2193 -3572
RNF5 -7255 -905
RPS27A -2775 -2092
PSMC1 -2073 -2143
AMFR -4049 -1070
RNF139 -2883 -826

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
AMFR -4049 -1070
CALR -7600 3622
CANX -7544 -4761
DERL1 -6455 4785
DERL2 -7492 -5988
EDEM1 -7562 4754
EDEM2 -5920 3449
EDEM3 -1724 3539
ENGASE 7406 4933
GANAB 2891 -5477
MAN1B1 -3754 -5405
MARCH6 -3796 -5054
MLEC -7311 4129
MOGS -2193 -3572
NGLY1 -2840 -3002
OS9 -7438 4312
PDIA3 -7547 -4672
PRKCSH -6303 -4165
PSMC1 -2073 -2143
RAD23B 3228 -6749
RNF103 -6285 4554
RNF139 -2883 -826
RNF185 -6322 3615
RNF5 -7255 -905
RPS27A -2775 -2092
SEL1L -7581 6447
SYVN1 -7570 4301
TRIM13 1936 -6313
UBA52 -5323 1252
UBB -3737 1627
UBC 931 -2324
UBXN1 -5821 505
UGGT1 -7364 -2124
UGGT2 1285 3828
VCP -7126 -4707



ROS and RNS production in phagocytes

metric value
setSize 26
pMANOVA 3.19e-06
p.adjustMANOVA 3.74e-05
s.dist 0.571
confESp NA
s.rna_LGvHG -0.395
s.rna_HGvHGV 0.413
p.rna_LGvHG 0.000489
p.rna_HGvHGV 0.000268




Gene rna_LGvHG rna_HGvHGV
ATP6V1C2 -7299 7568
ATP6V0D1 -7372 7138
ATP6V0A1 -7400 6911
ATP6V1D -7342 6245
ATP6V1E1 -6599 6485
ATP6V0E1 -7056 5745
ATP6V0B -7527 4877
ATP6V1B2 -5777 4883
ATP6V1A -3869 6191
ATP6V1H -4617 4704
NOS3 -5605 3817
ATP6V1C1 -4984 3557
ATP6V0A4 -1514 8045
ATP6V1F -1466 6142
TCIRG1 -77 4001

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
ATP6V0A1 -7400 6911
ATP6V0A2 -7288 -5276
ATP6V0A4 -1514 8045
ATP6V0B -7527 4877
ATP6V0C -3600 -2751
ATP6V0D1 -7372 7138
ATP6V0E1 -7056 5745
ATP6V0E2 6222 -4429
ATP6V1A -3869 6191
ATP6V1B1 6426 4649
ATP6V1B2 -5777 4883
ATP6V1C1 -4984 3557
ATP6V1C2 -7299 7568
ATP6V1D -7342 6245
ATP6V1E1 -6599 6485
ATP6V1E2 -514 -1244
ATP6V1F -1466 6142
ATP6V1G1 -5622 -198
ATP6V1G2 5807 7404
ATP6V1H -4617 4704
CYBA 2721 -812
HVCN1 7610 8008
NCF2 -6987 -2090
NOS3 -5605 3817
SLC11A1 4891 6632
TCIRG1 -77 4001



SRP-dependent cotranslational protein targeting to membrane

metric value
setSize 108
pMANOVA 5.71e-23
p.adjustMANOVA 7.22e-21
s.dist 0.562
confESp NA
s.rna_LGvHG -0.478
s.rna_HGvHGV -0.295
p.rna_LGvHG 8.76e-18
p.rna_HGvHGV 1.19e-07




Gene rna_LGvHG rna_HGvHGV
SRP68 -6776 -5056.0
SRP72 -5764 -5825.0
SRP14 -6238 -4757.0
RPL10 -5543 -4999.0
RPN1 -7473 -3567.0
DDOST -6834 -3695.0
RPL6 -5151 -4811.0
SEC61A1 -7486 -3284.0
SPCS2 -5875 -4003.0
RPL19 -5609 -3966.0
RPL36AL -7445 -2641.0
RPS27L -3395 -5791.0
RPL27A -4506 -4250.0
RPL21 -4209 -4036.5
TRAM1 -7465 -2243.0
SRPRB -7298 -2276.0
RPN2 -6500 -2540.0
SSR4 -7460 -2082.0
RPS11 -5078 -2933.0
RPL14 -5527 -2682.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
DDOST -6834 -3695.0
FAU -5465 -1439.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPN1 -7473 -3567.0
RPN2 -6500 -2540.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
SEC11A -2987 -1061.0
SEC11C -7434 -226.0
SEC61A1 -7486 -3284.0
SEC61A2 -228 7423.0
SEC61B -7405 -1370.0
SEC61G -4313 1345.0
SPCS1 2445 -153.0
SPCS2 -5875 -4003.0
SPCS3 -7033 985.0
SRP14 -6238 -4757.0
SRP19 -5678 1314.0
SRP54 -1869 5323.0
SRP68 -6776 -5056.0
SRP72 -5764 -5825.0
SRP9 6418 -949.0
SRPRB -7298 -2276.0
SSR1 -7335 -1989.0
SSR2 -7198 536.0
SSR3 -7349 -873.0
SSR4 -7460 -2082.0
TRAM1 -7465 -2243.0
UBA52 -5323 1252.0



Ribosomal scanning and start codon recognition

metric value
setSize 57
pMANOVA 4.01e-12
p.adjustMANOVA 1.15e-10
s.dist 0.553
confESp NA
s.rna_LGvHG -0.412
s.rna_HGvHGV -0.369
p.rna_LGvHG 7.45e-08
p.rna_HGvHGV 1.45e-06




Gene rna_LGvHG rna_HGvHGV
EIF4B -6017 -7498
EIF5 -6424 -6989
EIF4G1 -6162 -7098
EIF3A -7417 -4849
EIF3B -5113 -5476
EIF3J -4525 -6126
EIF2S2 -4423 -5981
EIF4H -4861 -4850
EIF3G -4897 -4671
EIF3D -3836 -5783
RPS27L -3395 -5791
RPS11 -5078 -2933
RPS7 -5915 -2189
RPS19 -4961 -2582
RPS9 -4220 -3027
RPS4X -3384 -3144
RPS2 -3922 -2651
RPS14 -3593 -2671
RPS12 -4503 -2114
RPS27 -3410 -2769

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
EIF1AX 1986 3709
EIF2S1 -5366 2409
EIF2S2 -4423 -5981
EIF2S3 -3280 -1720
EIF3A -7417 -4849
EIF3B -5113 -5476
EIF3C 1948 -5119
EIF3D -3836 -5783
EIF3E 3525 -2684
EIF3F -612 -5160
EIF3G -4897 -4671
EIF3H 1030 -953
EIF3I -5628 -499
EIF3J -4525 -6126
EIF3K -2175 -767
EIF3L -2260 -3369
EIF3M -4437 -1125
EIF4A1 241 -4341
EIF4A2 5877 -5660
EIF4B -6017 -7498
EIF4E 2829 494
EIF4G1 -6162 -7098
EIF4H -4861 -4850
EIF5 -6424 -6989
FAU -5465 -1439
RPS10 112 -1083
RPS11 -5078 -2933
RPS12 -4503 -2114
RPS13 -2629 -2290
RPS14 -3593 -2671
RPS15 -4564 -1911
RPS15A -3125 -197
RPS16 -3362 -2103
RPS18 -2870 -2001
RPS19 -4961 -2582
RPS2 -3922 -2651
RPS20 -1741 -1314
RPS21 -2922 -743
RPS23 -1789 -1850
RPS24 -2865 -1728
RPS25 -124 -980
RPS26 239 -3326
RPS27 -3410 -2769
RPS27A -2775 -2092
RPS27L -3395 -5791
RPS28 -3558 -1760
RPS29 -3554 19
RPS3 -2626 -1940
RPS3A 1310 -2352
RPS4X -3384 -3144
RPS4Y1 -2083 -2421
RPS5 -5073 439
RPS6 -2847 -2731
RPS7 -5915 -2189
RPS8 -1202 -2865
RPS9 -4220 -3027
RPSA -2539 -2294



Here is the session info with all the versions of packages used.

devtools::session_info()
## ─ Session info ──────────────────────────────────────────────────────────
##  setting  value                       
##  version  R version 3.6.0 (2019-04-26)
##  os       Ubuntu 18.04.2 LTS          
##  system   x86_64, linux-gnu           
##  ui       X11                         
##  language (EN)                        
##  collate  en_AU.UTF-8                 
##  ctype    en_AU.UTF-8                 
##  tz       Australia/Melbourne         
##  date     2019-06-11                  
## 
## ─ Packages ──────────────────────────────────────────────────────────────
##  package      * version    date       lib
##  assertthat     0.2.1      2019-03-21 [2]
##  backports      1.1.4      2019-04-10 [2]
##  bitops         1.0-6      2013-08-17 [1]
##  callr          3.2.0      2019-03-15 [2]
##  caTools        1.17.1.2   2019-03-06 [1]
##  cli            1.1.0      2019-03-19 [2]
##  colorspace     1.4-1      2019-03-18 [2]
##  crayon         1.3.4      2017-09-16 [2]
##  desc           1.2.0      2018-05-01 [1]
##  devtools       2.0.2      2019-04-08 [1]
##  digest         0.6.19     2019-05-20 [1]
##  dplyr        * 0.8.1      2019-05-14 [1]
##  evaluate       0.14       2019-05-28 [1]
##  fs             1.3.0      2019-05-02 [2]
##  gdata          2.18.0     2017-06-06 [1]
##  GGally       * 1.4.0      2018-05-17 [1]
##  ggplot2      * 3.1.1      2019-04-07 [2]
##  glue           1.3.1      2019-03-12 [2]
##  gplots       * 3.0.1.1    2019-01-27 [1]
##  gridExtra    * 2.3        2017-09-09 [1]
##  gtable         0.3.0      2019-03-25 [2]
##  gtools       * 3.8.1      2018-06-26 [1]
##  highr          0.8        2019-03-20 [2]
##  htmltools      0.3.6      2017-04-28 [2]
##  htmlwidgets    1.3        2018-09-30 [1]
##  jsonlite       1.6        2018-12-07 [2]
##  KernSmooth     2.23-15    2015-06-29 [4]
##  knitr        * 1.23       2019-05-18 [1]
##  labeling       0.3        2014-08-23 [2]
##  lattice      * 0.20-38    2018-11-04 [4]
##  lazyeval       0.2.2      2019-03-15 [2]
##  magrittr       1.5        2014-11-22 [2]
##  markdown     * 0.9        2018-12-07 [2]
##  MASS           7.3-51.4   2019-04-26 [4]
##  memoise        1.1.0      2017-04-21 [1]
##  mitch        * 0.0.0.9000 2019-06-11 [1]
##  munsell        0.5.0      2018-06-12 [2]
##  pbmcapply    * 1.4.1      2019-04-01 [1]
##  pillar         1.4.1      2019-05-28 [1]
##  pkgbuild       1.0.3      2019-03-20 [1]
##  pkgconfig      2.0.2      2018-08-16 [2]
##  pkgload        1.0.2      2018-10-29 [1]
##  plyr         * 1.8.4      2016-06-08 [2]
##  prettyunits    1.0.2      2015-07-13 [2]
##  processx       3.3.0      2019-03-10 [2]
##  ps             1.3.0      2018-12-21 [2]
##  purrr          0.3.2      2019-03-15 [2]
##  R6             2.4.0      2019-02-14 [2]
##  RColorBrewer   1.1-2      2014-12-07 [2]
##  Rcpp           1.0.1      2019-03-17 [2]
##  remotes        2.0.4      2019-04-10 [2]
##  reshape        0.8.8      2018-10-23 [1]
##  reshape2     * 1.4.3      2017-12-11 [2]
##  rlang          0.3.4      2019-04-07 [2]
##  rmarkdown    * 1.13       2019-05-22 [1]
##  Rmisc        * 1.5        2013-10-22 [1]
##  rprojroot      1.3-2      2018-01-03 [1]
##  scales         1.0.0      2018-08-09 [2]
##  sessioninfo    1.1.1      2018-11-05 [1]
##  sm           * 2.2-5.6    2018-09-27 [1]
##  stringi        1.4.3      2019-03-12 [2]
##  stringr        1.4.0      2019-02-10 [2]
##  taucharts    * 0.4.5      2019-05-31 [1]
##  tibble         2.1.2      2019-05-29 [1]
##  tidyselect     0.2.5      2018-10-11 [2]
##  usethis        1.5.0      2019-04-07 [1]
##  vioplot      * 0.3.0      2019-01-25 [1]
##  withr          2.1.2      2018-03-15 [2]
##  xfun           0.7        2019-05-14 [1]
##  yaml           2.2.0      2018-07-25 [2]
##  zoo          * 1.8-6      2019-05-28 [1]
##  source                             
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##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  Github (hrbrmstr/taucharts@93dbdce)
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
##  CRAN (R 3.6.0)                     
## 
## [1] /home/mdz/R/x86_64-pc-linux-gnu-library/3.6
## [2] /usr/local/lib/R/site-library
## [3] /usr/lib/R/site-library
## [4] /usr/lib/R/library

END of report